Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice. Ahowesso, C, Piccolo, E, Li, X M, Dulong, S, Hossard, V, La Sorda, R, Filipski, E, Tinari, N, Delaunay, F, Iacobelli, S, & Lévi, F Toxicol Lett, 192(3):395–401, 2010. ![Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Irinotecan hydrochloride (CPT-11) can display severe toxicities in individual cancer patients. CPT-11 is bio-activated through CES, detoxified through UGT1A1 and inhibits TOP1. CPT-11 toxicity and UGT1A1, CES2 and TOP1 mRNAs and UGT1A1 protein were determined in male and female C57BL/6, B6D2F1 and B6CBAF1, as potential models for tailoring CPT-11 delivery. CPT-11 was administered intravenously (40-90 mg/kg/day for 4 days at 7h after light onset). The relations between dose and lethal toxicity or body weight loss were steep and similar in C57BL/6 (lethality, p=0.001; weight loss, p=0.002) and B6D2F1 (p=0.01; p=0.03, respectively), but weak in B6CBAF1. Females displayed less toxicity than males (p\textless0.001). Mean mRNA expression of UGT1A1 was highest in B6CBAF1 (p=0.039) and in females (p\textless0.001). Both CES2 and TOP1 varied according to strain and gender (p\textless0.001). The three gene expression data explained the most severe toxicity of CPT-11 in male B6D2F1, but displayed inconsistent relations with toxicity in the other groups. Mean UGT1A1 protein expression was highest in males as compared to females, and so by approximately 8-fold in C57BL/6 as compared to B6D2F1 (p\textless0.0001). Genetic background and gender significantly altered the molecular prediction of irinotecan toxicity by UGT1A1, CES2 and TOP1 mRNA expressions.
@article{ahowesso_relations_2010,
title = {Relations between strain and gender dependencies of irinotecan toxicity and {UGT1A1}, {CES2} and {TOP1} expressions in mice},
volume = {192},
issn = {1879-3169},
shorttitle = {Relations between strain and gender dependencies of irinotecan toxicity and {UGT1A1}, {CES2} and {TOP1} expressions in mice},
url = {http://dx.doi.org/10.1016/j.toxlet.2009.11.017},
abstract = {Irinotecan hydrochloride (CPT-11) can display severe toxicities in individual cancer patients. CPT-11 is bio-activated through CES, detoxified through UGT1A1 and inhibits TOP1. CPT-11 toxicity and UGT1A1, CES2 and TOP1 mRNAs and UGT1A1 protein were determined in male and female C57BL/6, B6D2F1 and B6CBAF1, as potential models for tailoring CPT-11 delivery. CPT-11 was administered intravenously (40-90 mg/kg/day for 4 days at 7h after light onset). The relations between dose and lethal toxicity or body weight loss were steep and similar in C57BL/6 (lethality, p=0.001; weight loss, p=0.002) and B6D2F1 (p=0.01; p=0.03, respectively), but weak in B6CBAF1. Females displayed less toxicity than males (p{\textless}0.001). Mean mRNA expression of UGT1A1 was highest in B6CBAF1 (p=0.039) and in females (p{\textless}0.001). Both CES2 and TOP1 varied according to strain and gender (p{\textless}0.001). The three gene expression data explained the most severe toxicity of CPT-11 in male B6D2F1, but displayed inconsistent relations with toxicity in the other groups. Mean UGT1A1 protein expression was highest in males as compared to females, and so by approximately 8-fold in C57BL/6 as compared to B6D2F1 (p{\textless}0.0001). Genetic background and gender significantly altered the molecular prediction of irinotecan toxicity by UGT1A1, CES2 and TOP1 mRNA expressions.},
number = {3},
journal = {Toxicol Lett},
author = {Ahowesso, C and Piccolo, E and Li, X M and Dulong, S and Hossard, V and La Sorda, R and Filipski, E and Tinari, N and Delaunay, F and Iacobelli, S and Lévi, F},
year = {2010},
pages = {395--401},
}
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{"_id":"B5aKyAW5vinyef5Ag","bibbaseid":"ahowesso-piccolo-li-dulong-hossard-lasorda-filipski-tinari-etal-relationsbetweenstrainandgenderdependenciesofirinotecantoxicityandugt1a1ces2andtop1expressionsinmice-2010","author_short":["Ahowesso, C","Piccolo, E","Li, X M","Dulong, S","Hossard, V","La Sorda, R","Filipski, E","Tinari, N","Delaunay, F","Iacobelli, S","Lévi, F"],"bibdata":{"bibtype":"article","type":"article","title":"Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice","volume":"192","issn":"1879-3169","shorttitle":"Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice","url":"http://dx.doi.org/10.1016/j.toxlet.2009.11.017","abstract":"Irinotecan hydrochloride (CPT-11) can display severe toxicities in individual cancer patients. CPT-11 is bio-activated through CES, detoxified through UGT1A1 and inhibits TOP1. CPT-11 toxicity and UGT1A1, CES2 and TOP1 mRNAs and UGT1A1 protein were determined in male and female C57BL/6, B6D2F1 and B6CBAF1, as potential models for tailoring CPT-11 delivery. CPT-11 was administered intravenously (40-90 mg/kg/day for 4 days at 7h after light onset). The relations between dose and lethal toxicity or body weight loss were steep and similar in C57BL/6 (lethality, p=0.001; weight loss, p=0.002) and B6D2F1 (p=0.01; p=0.03, respectively), but weak in B6CBAF1. Females displayed less toxicity than males (p\\textless0.001). Mean mRNA expression of UGT1A1 was highest in B6CBAF1 (p=0.039) and in females (p\\textless0.001). Both CES2 and TOP1 varied according to strain and gender (p\\textless0.001). The three gene expression data explained the most severe toxicity of CPT-11 in male B6D2F1, but displayed inconsistent relations with toxicity in the other groups. Mean UGT1A1 protein expression was highest in males as compared to females, and so by approximately 8-fold in C57BL/6 as compared to B6D2F1 (p\\textless0.0001). Genetic background and gender significantly altered the molecular prediction of irinotecan toxicity by UGT1A1, CES2 and TOP1 mRNA expressions.","number":"3","journal":"Toxicol Lett","author":[{"propositions":[],"lastnames":["Ahowesso"],"firstnames":["C"],"suffixes":[]},{"propositions":[],"lastnames":["Piccolo"],"firstnames":["E"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["X","M"],"suffixes":[]},{"propositions":[],"lastnames":["Dulong"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["Hossard"],"firstnames":["V"],"suffixes":[]},{"propositions":[],"lastnames":["La","Sorda"],"firstnames":["R"],"suffixes":[]},{"propositions":[],"lastnames":["Filipski"],"firstnames":["E"],"suffixes":[]},{"propositions":[],"lastnames":["Tinari"],"firstnames":["N"],"suffixes":[]},{"propositions":[],"lastnames":["Delaunay"],"firstnames":["F"],"suffixes":[]},{"propositions":[],"lastnames":["Iacobelli"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["Lévi"],"firstnames":["F"],"suffixes":[]}],"year":"2010","pages":"395–401","bibtex":"@article{ahowesso_relations_2010,\n\ttitle = {Relations between strain and gender dependencies of irinotecan toxicity and {UGT1A1}, {CES2} and {TOP1} expressions in mice},\n\tvolume = {192},\n\tissn = {1879-3169},\n\tshorttitle = {Relations between strain and gender dependencies of irinotecan toxicity and {UGT1A1}, {CES2} and {TOP1} expressions in mice},\n\turl = {http://dx.doi.org/10.1016/j.toxlet.2009.11.017},\n\tabstract = {Irinotecan hydrochloride (CPT-11) can display severe toxicities in individual cancer patients. CPT-11 is bio-activated through CES, detoxified through UGT1A1 and inhibits TOP1. CPT-11 toxicity and UGT1A1, CES2 and TOP1 mRNAs and UGT1A1 protein were determined in male and female C57BL/6, B6D2F1 and B6CBAF1, as potential models for tailoring CPT-11 delivery. CPT-11 was administered intravenously (40-90 mg/kg/day for 4 days at 7h after light onset). The relations between dose and lethal toxicity or body weight loss were steep and similar in C57BL/6 (lethality, p=0.001; weight loss, p=0.002) and B6D2F1 (p=0.01; p=0.03, respectively), but weak in B6CBAF1. Females displayed less toxicity than males (p{\\textless}0.001). Mean mRNA expression of UGT1A1 was highest in B6CBAF1 (p=0.039) and in females (p{\\textless}0.001). Both CES2 and TOP1 varied according to strain and gender (p{\\textless}0.001). The three gene expression data explained the most severe toxicity of CPT-11 in male B6D2F1, but displayed inconsistent relations with toxicity in the other groups. Mean UGT1A1 protein expression was highest in males as compared to females, and so by approximately 8-fold in C57BL/6 as compared to B6D2F1 (p{\\textless}0.0001). Genetic background and gender significantly altered the molecular prediction of irinotecan toxicity by UGT1A1, CES2 and TOP1 mRNA expressions.},\n\tnumber = {3},\n\tjournal = {Toxicol Lett},\n\tauthor = {Ahowesso, C and Piccolo, E and Li, X M and Dulong, S and Hossard, V and La Sorda, R and Filipski, E and Tinari, N and Delaunay, F and Iacobelli, S and Lévi, F},\n\tyear = {2010},\n\tpages = {395--401},\n}\n\n\n\n","author_short":["Ahowesso, C","Piccolo, E","Li, X M","Dulong, S","Hossard, V","La Sorda, R","Filipski, E","Tinari, N","Delaunay, F","Iacobelli, S","Lévi, F"],"key":"ahowesso_relations_2010","id":"ahowesso_relations_2010","bibbaseid":"ahowesso-piccolo-li-dulong-hossard-lasorda-filipski-tinari-etal-relationsbetweenstrainandgenderdependenciesofirinotecantoxicityandugt1a1ces2andtop1expressionsinmice-2010","role":"author","urls":{"Paper":"http://dx.doi.org/10.1016/j.toxlet.2009.11.017"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://bibbase.org/zotero/biblioial","dataSources":["ftoP3zPyb2N3b9Noc"],"keywords":[],"search_terms":["relations","between","strain","gender","dependencies","irinotecan","toxicity","ugt1a1","ces2","top1","expressions","mice","ahowesso","piccolo","li","dulong","hossard","la sorda","filipski","tinari","delaunay","iacobelli","lévi"],"title":"Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice","year":2010}