Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors. Ahveninen, J., Kahkonen, S., Tiitinen, H., Pekkonen, E, Huttunen, J., Kaakkola, S., Ilmoniemi, R. J., & Jaaskelainen, I. Neurosci Lett, 292(1):29-32, 2000. abstract bibtex Cognitive Brain Research Unit, Department of Psychology, PO Box 13, FIN-00014 University of Helsinki, Helsinki, Finland. jyrki.ahveninen@helsinki.fi Cognitive processes including selective attention may depend on synchronous activity of neurons at the gamma-band (around 40Hz). To determine the effect of neuroleptic challenge on transient auditory evoked 40-Hz response, simultaneous measurement of 122-channel magnetoencephalogram (MEG) and 64-channel electroencephalogram (EEG) was used. Either 2mg of dopamine D(2)-receptor antagonist haloperidol or a placebo was administered orally to 11healthy subjects in a double-blind randomized crossover design in two separate sessions. The subjects attended to tones presented to one ear and ignored those presented to the other ear. Haloperidol significantly suppressed the transient 40-Hz electric response to the attended stimuli, while no significant effect was observed in the electric responses to the unattended tones or in the magnetic responses. The present result suggests that dopamine D(2) receptors modulate selective attention
@article{ Ahveninen_etal00,
author = {Ahveninen, J. and Kahkonen, S. and Tiitinen, H. and Pekkonen, E and
Huttunen, J. and Kaakkola, S. and Ilmoniemi, R. J. and Jaaskelainen,
I.},
title = {Suppression of transient 40-Hz auditory response by haloperidol suggests
modulation of human selective attention by dopamine D2 receptors},
journal = {Neurosci Lett},
year = {2000},
volume = {292},
pages = {29-32},
number = {1},
abstract = {Cognitive Brain Research Unit, Department of Psychology, PO Box 13,
FIN-00014 University of Helsinki, Helsinki, Finland. jyrki.ahveninen@helsinki.fi
Cognitive processes including selective attention may depend on synchronous
activity of neurons at the gamma-band (around 40Hz). To determine
the effect of neuroleptic challenge on transient auditory evoked
40-Hz response, simultaneous measurement of 122-channel magnetoencephalogram
(MEG) and 64-channel electroencephalogram (EEG) was used. Either
2mg of dopamine D(2)-receptor antagonist haloperidol or a placebo
was administered orally to 11healthy subjects in a double-blind randomized
crossover design in two separate sessions. The subjects attended
to tones presented to one ear and ignored those presented to the
other ear. Haloperidol significantly suppressed the transient 40-Hz
electric response to the attended stimuli, while no significant effect
was observed in the electric responses to the unattended tones or
in the magnetic responses. The present result suggests that dopamine
D(2) receptors modulate selective attention}
}
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