Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors. Ahveninen, J., Kahkonen, S., Tiitinen, H., Pekkonen, E, Huttunen, J., Kaakkola, S., Ilmoniemi, R. J., & Jaaskelainen, I. Neurosci Lett, 292(1):29-32, 2000.
abstract   bibtex   
Cognitive Brain Research Unit, Department of Psychology, PO Box 13, FIN-00014 University of Helsinki, Helsinki, Finland. jyrki.ahveninen@helsinki.fi Cognitive processes including selective attention may depend on synchronous activity of neurons at the gamma-band (around 40Hz). To determine the effect of neuroleptic challenge on transient auditory evoked 40-Hz response, simultaneous measurement of 122-channel magnetoencephalogram (MEG) and 64-channel electroencephalogram (EEG) was used. Either 2mg of dopamine D(2)-receptor antagonist haloperidol or a placebo was administered orally to 11healthy subjects in a double-blind randomized crossover design in two separate sessions. The subjects attended to tones presented to one ear and ignored those presented to the other ear. Haloperidol significantly suppressed the transient 40-Hz electric response to the attended stimuli, while no significant effect was observed in the electric responses to the unattended tones or in the magnetic responses. The present result suggests that dopamine D(2) receptors modulate selective attention
@article{ Ahveninen_etal00,
  author = {Ahveninen, J. and Kahkonen, S. and Tiitinen, H. and Pekkonen, E and
	Huttunen, J. and Kaakkola, S. and Ilmoniemi, R. J. and Jaaskelainen,
	I.},
  title = {Suppression of transient 40-Hz auditory response by haloperidol suggests
	modulation of human selective attention by dopamine D2 receptors},
  journal = {Neurosci Lett},
  year = {2000},
  volume = {292},
  pages = {29-32},
  number = {1},
  abstract = {Cognitive Brain Research Unit, Department of Psychology, PO Box 13,
	FIN-00014 University of Helsinki, Helsinki, Finland. jyrki.ahveninen@helsinki.fi
	
	
	Cognitive processes including selective attention may depend on synchronous
	activity of neurons at the gamma-band (around 40Hz). To determine
	the effect of neuroleptic challenge on transient auditory evoked
	40-Hz response, simultaneous measurement of 122-channel magnetoencephalogram
	(MEG) and 64-channel electroencephalogram (EEG) was used. Either
	2mg of dopamine D(2)-receptor antagonist haloperidol or a placebo
	was administered orally to 11healthy subjects in a double-blind randomized
	crossover design in two separate sessions. The subjects attended
	to tones presented to one ear and ignored those presented to the
	other ear. Haloperidol significantly suppressed the transient 40-Hz
	electric response to the attended stimuli, while no significant effect
	was observed in the electric responses to the unattended tones or
	in the magnetic responses. The present result suggests that dopamine
	D(2) receptors modulate selective attention}
}

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