Process-specific somatic mutation distributions vary with three-dimensional genome structure. Akdemir, K. C, Le, V. T, Killcoyne, S., King, D. A, Li, Y., Lian, Y., Inoue, A., Amin, S., Robinson, F. S, Herrera, R. E, Lynn, E. J, Chan, K., Seth, S., Klimczak, L. J, Gerstung, M., Gordenin, D. A, O\textquoterightBrien, J., Li, L., Verhaak, R. G, Campbell, P., Fitzgerald, R., Morrison, A. J, Dixon, J. R, & Futreal, A. bioRxiv, Cold Spring Harbor Laboratory, 2018.
Process-specific somatic mutation distributions vary with three-dimensional genome structure [link]Paper  doi  abstract   bibtex   
Somatic mutations arise during the life history of a cell. Mutations occurring in cancer driver genes may ultimately lead to the development of clinically detectable disease. Nascent cancer lineages continue to acquire somatic mutations throughout the neoplastic process and during cancer evolution. Extrinsic and endogenous mutagenic factors contribute to the accumulation of these somatic mutations. Understanding the underlying factors generating somatic mutations is crucial for developing potential preventive, therapeutic and clinical decisions. Earlier studies have revealed that DNA replication timing and chromatin modifications are associated with variations in mutational density. What is unclear from these early studies, however, is whether all extrinsic and exogenous factors that drive somatic mutational processes share a similar relationship with chromatin state and structure. In order to understand the interplay between spatial genome organization and specific individual mutational processes, we report here a study of 3000 tumor-normal pair whole genome datasets from more than 40 different human cancer types. Our analyses revealed that different mutational processes lead to distinct somatic mutation distributions between chromatin folding domains. APOBEC- or MSI-related mutations are enriched in transcriptionally-active domains while mutations occurring due to tobacco-smoke, ultraviolet (UV) light exposure or a signature of unknown aetiology (signature 17) enrich predominantly in transcriptionally-inactive domains. Active mutational processes dictate the mutation distributions in cancer genomes, and we show that mutational distributions shift during cancer evolution upon mutational processes switch. Moreover, a dramatic instance of extreme chromatin structure in humans, that of the unique folding pattern of the inactive X-chromosome leads to distinct somatic mutation distribution on X chromosome in females compared to males in various cancer types. Overall, the interplay between three-dimensional genome organization and active mutational processes has a substantial influence on the large-scale mutation rate variations observed in human cancer.
@ARTICLE{Akdemir426080,
  author = {Akdemir, Kadir C and Le, Victoria T and Killcoyne, Sarah and King, Devin A and Li, Ya-Ping and Lian, Yanyan and Inoue, Akire and Amin, Samir and Robinson, Frederick S and Herrera, Rafael E and Lynn, Erica J and Chan, Kin and Seth, Sahil and Klimczak, Leszek J and Gerstung, Moritz and Gordenin, Dmitry A and O{\textquoteright}Brien, John and Li, Lei and Verhaak, Roel G and Campbell, Peter and Fitzgerald, Rebecca and Morrison, Ashby J and Dixon, Jesse R and Futreal, Andrew},
  title = {Process-specific somatic mutation distributions vary with three-dimensional genome structure},
  year = {2018},
  doi = {10.1101/426080},
  publisher = {Cold Spring Harbor Laboratory},
  abstract = {Somatic mutations arise during the life history of a cell. Mutations occurring in cancer driver genes may ultimately lead to the development of clinically detectable disease. Nascent cancer lineages continue to acquire somatic mutations throughout the neoplastic process and during cancer evolution. Extrinsic and endogenous mutagenic factors contribute to the accumulation of these somatic mutations. Understanding the underlying factors generating somatic mutations is crucial for developing potential preventive, therapeutic and clinical decisions. Earlier studies have revealed that DNA replication timing and chromatin modifications are associated with variations in mutational density. What is unclear from these early studies, however, is whether all extrinsic and exogenous factors that drive somatic mutational processes share a similar relationship with chromatin state and structure. In order to understand the interplay between spatial genome organization and specific individual mutational processes, we report here a study of 3000 tumor-normal pair whole genome datasets from more than 40 different human cancer types. Our analyses revealed that different mutational processes lead to distinct somatic mutation distributions between chromatin folding domains. APOBEC- or MSI-related mutations are enriched in transcriptionally-active domains while mutations occurring due to tobacco-smoke, ultraviolet (UV) light exposure or a signature of unknown aetiology (signature 17) enrich predominantly in transcriptionally-inactive domains. Active mutational processes dictate the mutation distributions in cancer genomes, and we show that mutational distributions shift during cancer evolution upon mutational processes switch. Moreover, a dramatic instance of extreme chromatin structure in humans, that of the unique folding pattern of the inactive X-chromosome leads to distinct somatic mutation distribution on X chromosome in females compared to males in various cancer types. Overall, the interplay between three-dimensional genome organization and active mutational processes has a substantial influence on the large-scale mutation rate variations observed in human cancer.},
  URL = {https://www.biorxiv.org/content/early/2018/09/25/426080},
  eprint = {https://www.biorxiv.org/content/early/2018/09/25/426080.full.pdf},
  journal = {bioRxiv},
  authorclass = {coauthor},
  contribution = {design,discussion},
  affiliation = {JAX}
}
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