Antiviral activity of poly(A)·poly(U) duplexes modified with cis-diammine dichloroplatinum (II). Aksenov, O.; Platonova, G.; and Timkovsky, A. Antibiotiki i Khimioterapiya, 44(6):12-15, 1999. cited By 1
Antiviral activity of poly(A)·poly(U) duplexes modified with cis-diammine dichloroplatinum (II) [link]Paper  abstract   bibtex   
Polyribonucleotide duplex poly(A)·poly(U) was modified with cis-diammine dichloroplatinum (II) (cis-DDP). It was shown that the antiinfluenza protective activity of the modified duplex in mice increased with the degree of modification (rb) rising up to 0.2. The effect was different from that for poly(I)·poly(C) and poly(G)·poly(C). The interferon titers in the murine brain increased in parallel with increasing of the antiviral activity. It was assumed that the structural specificity of the poly(A)·poly(U) duplex was responsible for the phenomenon and that cis-DDP interaction with N(7) atoms of the adenine heterocycles blocked the "abnormal" Hoogsteen pairing of adenines with uracils. As a result the antiviral activity increased because of lowering the quantity of the intramolecular defects and increasing the length of the regular double-stranded regions.
@ARTICLE{Aksenov199912,
author={Aksenov, O.A. and Platonova, G.A. and Timkovsky, A.L.},
title={Antiviral activity of poly(A)·poly(U) duplexes modified with cis-diammine dichloroplatinum (II)},
journal={Antibiotiki i Khimioterapiya},
year={1999},
volume={44},
number={6},
pages={12-15},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032618973&partnerID=40&md5=d9031f39714de853585bf07b5b4bd1ec},
abstract={Polyribonucleotide duplex poly(A)·poly(U) was modified with cis-diammine dichloroplatinum (II) (cis-DDP). It was shown that the antiinfluenza protective activity of the modified duplex in mice increased with the degree of modification (rb) rising up to 0.2. The effect was different from that for poly(I)·poly(C) and poly(G)·poly(C). The interferon titers in the murine brain increased in parallel with increasing of the antiviral activity. It was assumed that the structural specificity of the poly(A)·poly(U) duplex was responsible for the phenomenon and that cis-DDP interaction with N(7) atoms of the adenine heterocycles blocked the "abnormal" Hoogsteen pairing of adenines with uracils. As a result the antiviral activity increased because of lowering the quantity of the intramolecular defects and increasing the length of the regular double-stranded regions.},
author_keywords={Antiviral activity;  cis-diammine dichloroplatinum (II);  Polyribonucleotide duplexes},
issn={02352990},
coden={ANKHE},
pubmed_id={10422572},
language={Russian},
abbrev_source_title={Antibiot. Khimioter.},
document_type={Article},
source={Scopus},
}
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