@article{albanese_effect_2011,
	title = {Effect of {Gold} {Nanoparticle} {Aggregation} on {Cell} {Uptake} and {Toxicity}},
	volume = {5},
	issn = {1936-0851},
	url = {https://doi.org/10.1021/nn2007496},
	doi = {10.1021/nn2007496},
	abstract = {Aggregation appears to be a ubiquitous phenomenon among all nanoparticles and its influence in mediating cellular uptake and interactions remain unclear. Here we developed a simple technique to produce transferrin-coated gold nanoparticle aggregates of different sizes and characterized their uptake and toxicity in three different cell lines. While the aggregation did not elicit a unique toxic response, the uptake patterns were different between single and aggregated nanoparticles. There was a 25\% decrease in uptake of aggregated nanoparticles with HeLa and A549 cells in comparison to single and monodisperse nanoparticles. However, there was a 2-fold increase in MDA-MB 435 cell uptake for the largest synthesized aggregates. These contrasting results suggest that cell type and the mechanism of interactions may play a significant role. This study highlights the need to investigate the behavior of aggregates with cells on a case-by-case basis and the importance of aggregation in mediating targeting and intracellular trafficking.},
	number = {7},
	urldate = {2021-11-06},
	journal = {ACS Nano},
	author = {Albanese, Alexandre and Chan, Warren C.W.},
	month = jul,
	year = {2011},
	note = {Publisher: American Chemical Society},
	pages = {5478--5489},
	file = {Full Text PDF:files/2110/Albanese and Chan - 2011 - Effect of Gold Nanoparticle Aggregation on Cell Up.pdf:application/pdf;ACS Full Text Snapshot:files/2114/nn2007496.html:text/html},
	url_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/nn2007496-min.pdf}
}

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