@article{Alberti2001,
	title = {Interaction of an acridine dimer with {DNA} quadruplex structures.},
	volume = {19},
	issn = {0739-1102},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11790148},
	abstract = {The reactivation of telomerase activity in most cancer cells supports the concept that telomerase is a relevant target in oncology, and telomerase inhibitors have been proposed as new potential anticancer agents. The telomeric G-rich single-stranded DNA can adopt an intramolecular G-quadruplex structure in vitro, which has been shown to inhibit telomerase activity. The C-rich sequence can also adopt a quadruplex (intercalated) structure (i-DNA). Two acridine derivatives were shown to increase the melting temperature of the G- quadruplex and the C-quadruplex at 1 microM dye concentration. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro. The most active compound, "BisA", showed an IC(50) value of 0.75 microM in a standard TRAP assay.},
	number = {3},
	journal = {Journal of biomolecular structure \& dynamics},
	author = {Alberti, P and Ren, J and Teulade-Fichou, M P and Guittat, L and Riou, J F and Chaires, J and Hélène, C and Vigneron, J P and Lehn, J M and Mergny, J L},
	month = dec,
	year = {2001},
	pmid = {11790148},
	keywords = {\#nosource, Acridines, Acridines: chemistry, Acridines: metabolism, Binding Sites, Bridged Compounds, Bridged Compounds: chemistry, Bridged Compounds: metabolism, Cytosine, Cytosine: chemistry, DNA, DNA: chemistry, DNA: metabolism, Dimerization, Enzyme Inhibitors, Enzyme Inhibitors: chemistry, Enzyme Inhibitors: metabolism, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: metabolism, G-Quadruplexes, Guanine, Guanine: chemistry, Humans, Kinetics, Ligands, Nucleic Acid Conformation, Oligonucleotides, Oligonucleotides: chemistry, Rhodamines, Rhodamines: metabolism, Single-Stranded, Single-Stranded: chemistry, Spectrometry, Telomerase, Telomerase: metabolism, Telomere, Telomere: chemistry, Temperature},
	pages = {505--13},
}

{"_id":"e9zpmnm6h6jBeeH4p","bibbaseid":"alberti-ren-teuladefichou-guittat-riou-chaires-hlne-vigneron-etal-interactionofanacridinedimerwithdnaquadruplexstructures-2001","author_short":["Alberti, P","Ren, J","Teulade-Fichou, M P","Guittat, L","Riou, J F","Chaires, J","Hélène, C","Vigneron, J P","Lehn, J M","Mergny, J L"],"bibdata":{"bibtype":"article","type":"article","title":"Interaction of an acridine dimer with DNA quadruplex structures.","volume":"19","issn":"0739-1102","url":"http://www.ncbi.nlm.nih.gov/pubmed/11790148","abstract":"The reactivation of telomerase activity in most cancer cells supports the concept that telomerase is a relevant target in oncology, and telomerase inhibitors have been proposed as new potential anticancer agents. The telomeric G-rich single-stranded DNA can adopt an intramolecular G-quadruplex structure in vitro, which has been shown to inhibit telomerase activity. The C-rich sequence can also adopt a quadruplex (intercalated) structure (i-DNA). Two acridine derivatives were shown to increase the melting temperature of the G- quadruplex and the C-quadruplex at 1 microM dye concentration. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro. The most active compound, \"BisA\", showed an IC(50) value of 0.75 microM in a standard TRAP assay.","number":"3","journal":"Journal of biomolecular structure & dynamics","author":[{"propositions":[],"lastnames":["Alberti"],"firstnames":["P"],"suffixes":[]},{"propositions":[],"lastnames":["Ren"],"firstnames":["J"],"suffixes":[]},{"propositions":[],"lastnames":["Teulade-Fichou"],"firstnames":["M","P"],"suffixes":[]},{"propositions":[],"lastnames":["Guittat"],"firstnames":["L"],"suffixes":[]},{"propositions":[],"lastnames":["Riou"],"firstnames":["J","F"],"suffixes":[]},{"propositions":[],"lastnames":["Chaires"],"firstnames":["J"],"suffixes":[]},{"propositions":[],"lastnames":["Hélène"],"firstnames":["C"],"suffixes":[]},{"propositions":[],"lastnames":["Vigneron"],"firstnames":["J","P"],"suffixes":[]},{"propositions":[],"lastnames":["Lehn"],"firstnames":["J","M"],"suffixes":[]},{"propositions":[],"lastnames":["Mergny"],"firstnames":["J","L"],"suffixes":[]}],"month":"December","year":"2001","pmid":"11790148","keywords":"#nosource, Acridines, Acridines: chemistry, Acridines: metabolism, Binding Sites, Bridged Compounds, Bridged Compounds: chemistry, Bridged Compounds: metabolism, Cytosine, Cytosine: chemistry, DNA, DNA: chemistry, DNA: metabolism, Dimerization, Enzyme Inhibitors, Enzyme Inhibitors: chemistry, Enzyme Inhibitors: metabolism, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: metabolism, G-Quadruplexes, Guanine, Guanine: chemistry, Humans, Kinetics, Ligands, Nucleic Acid Conformation, Oligonucleotides, Oligonucleotides: chemistry, Rhodamines, Rhodamines: metabolism, Single-Stranded, Single-Stranded: chemistry, Spectrometry, Telomerase, Telomerase: metabolism, Telomere, Telomere: chemistry, Temperature","pages":"505–13","bibtex":"@article{Alberti2001,\n\ttitle = {Interaction of an acridine dimer with {DNA} quadruplex structures.},\n\tvolume = {19},\n\tissn = {0739-1102},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/11790148},\n\tabstract = {The reactivation of telomerase activity in most cancer cells supports the concept that telomerase is a relevant target in oncology, and telomerase inhibitors have been proposed as new potential anticancer agents. The telomeric G-rich single-stranded DNA can adopt an intramolecular G-quadruplex structure in vitro, which has been shown to inhibit telomerase activity. The C-rich sequence can also adopt a quadruplex (intercalated) structure (i-DNA). Two acridine derivatives were shown to increase the melting temperature of the G- quadruplex and the C-quadruplex at 1 microM dye concentration. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro. The most active compound, \"BisA\", showed an IC(50) value of 0.75 microM in a standard TRAP assay.},\n\tnumber = {3},\n\tjournal = {Journal of biomolecular structure \\& dynamics},\n\tauthor = {Alberti, P and Ren, J and Teulade-Fichou, M P and Guittat, L and Riou, J F and Chaires, J and Hélène, C and Vigneron, J P and Lehn, J M and Mergny, J L},\n\tmonth = dec,\n\tyear = {2001},\n\tpmid = {11790148},\n\tkeywords = {\\#nosource, Acridines, Acridines: chemistry, Acridines: metabolism, Binding Sites, Bridged Compounds, Bridged Compounds: chemistry, Bridged Compounds: metabolism, Cytosine, Cytosine: chemistry, DNA, DNA: chemistry, DNA: metabolism, Dimerization, Enzyme Inhibitors, Enzyme Inhibitors: chemistry, Enzyme Inhibitors: metabolism, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: metabolism, G-Quadruplexes, Guanine, Guanine: chemistry, Humans, Kinetics, Ligands, Nucleic Acid Conformation, Oligonucleotides, Oligonucleotides: chemistry, Rhodamines, Rhodamines: metabolism, Single-Stranded, Single-Stranded: chemistry, Spectrometry, Telomerase, Telomerase: metabolism, Telomere, Telomere: chemistry, Temperature},\n\tpages = {505--13},\n}\n\n","author_short":["Alberti, P","Ren, J","Teulade-Fichou, M P","Guittat, L","Riou, J F","Chaires, J","Hélène, C","Vigneron, J P","Lehn, J M","Mergny, J L"],"key":"Alberti2001","id":"Alberti2001","bibbaseid":"alberti-ren-teuladefichou-guittat-riou-chaires-hlne-vigneron-etal-interactionofanacridinedimerwithdnaquadruplexstructures-2001","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/11790148"},"keyword":["#nosource","Acridines","Acridines: chemistry","Acridines: metabolism","Binding Sites","Bridged Compounds","Bridged Compounds: chemistry","Bridged Compounds: metabolism","Cytosine","Cytosine: chemistry","DNA","DNA: chemistry","DNA: metabolism","Dimerization","Enzyme Inhibitors","Enzyme Inhibitors: chemistry","Enzyme Inhibitors: metabolism","Fluorescence","Fluorescence: methods","Fluorescent Dyes","Fluorescent Dyes: metabolism","G-Quadruplexes","Guanine","Guanine: chemistry","Humans","Kinetics","Ligands","Nucleic Acid Conformation","Oligonucleotides","Oligonucleotides: chemistry","Rhodamines","Rhodamines: metabolism","Single-Stranded","Single-Stranded: chemistry","Spectrometry","Telomerase","Telomerase: metabolism","Telomere","Telomere: chemistry","Temperature"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/eric.larG4","dataSources":["4i5C7S78DvJNsaHyg","5L2zM5wNE5CBYNuea"],"keywords":["#nosource","acridines","acridines: chemistry","acridines: metabolism","binding sites","bridged compounds","bridged compounds: chemistry","bridged compounds: metabolism","cytosine","cytosine: chemistry","dna","dna: chemistry","dna: metabolism","dimerization","enzyme inhibitors","enzyme inhibitors: chemistry","enzyme inhibitors: metabolism","fluorescence","fluorescence: methods","fluorescent dyes","fluorescent dyes: metabolism","g-quadruplexes","guanine","guanine: chemistry","humans","kinetics","ligands","nucleic acid conformation","oligonucleotides","oligonucleotides: chemistry","rhodamines","rhodamines: metabolism","single-stranded","single-stranded: chemistry","spectrometry","telomerase","telomerase: metabolism","telomere","telomere: chemistry","temperature"],"search_terms":["interaction","acridine","dimer","dna","quadruplex","structures","alberti","ren","teulade-fichou","guittat","riou","chaires","hélène","vigneron","lehn","mergny"],"title":"Interaction of an acridine dimer with DNA quadruplex structures.","year":2001}