Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review. Alblooshi, S., Taylor, M., & Gill, N. Australasian Psychiatry, 31(2):165–173, April, 2023.
Paper doi abstract bibtex Objective To determine whether menopause elevates the risk for developing diagnostic depression and anxiety. Menopause-associated vasomotor symptoms such as insomnia and hot flushes are well recognized, but no systematic review of the psychological consequences of menopause has been undertaken. Menopause can be a time of social change for women, confounding any correlation. Methods Using PRISMA methodology, we conducted a systematic review of all published (in English) original data examining a relationship between menopause and depression and anxiety. We ranked the quality of all included studies using Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria. Results Twenty-two selected studies were summarized and compared, being eight cross-sectional surveys; one retrospective cohort, and 13 prospective cohort studies. Depression and anxiety are common during menopause and the post-menopause, with vasomotor symptoms and a prior history of major depression elevating risk of menopausal associated depression. Psychosocial factors also may increase risk of depression during menopause. Conclusions Menopause increases vulnerability to depression and anxiety, perhaps via estrogen fluctuations affecting serotonin and GABA. Underlying neuroticism and contemporaneous adverse life events are also risk factors for menopausal decompensation with depression.
@article{alblooshi_does_2023,
title = {Does menopause elevate the risk for developing depression and anxiety? {Results} from a systematic review},
volume = {31},
issn = {1039-8562},
shorttitle = {Does menopause elevate the risk for developing depression and anxiety?},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088347/},
doi = {10.1177/10398562231165439},
abstract = {Objective
To determine whether menopause elevates the risk for developing diagnostic depression and anxiety. Menopause-associated vasomotor symptoms such as insomnia and hot flushes are well recognized, but no systematic review of the psychological consequences of menopause has been undertaken. Menopause can be a time of social change for women, confounding any correlation.
Methods
Using PRISMA methodology, we conducted a systematic review of all published (in English) original data examining a relationship between menopause and depression and anxiety. We ranked the quality of all included studies using Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria.
Results
Twenty-two selected studies were summarized and compared, being eight cross-sectional surveys; one retrospective cohort, and 13 prospective cohort studies. Depression and anxiety are common during menopause and the post-menopause, with vasomotor symptoms and a prior history of major depression elevating risk of menopausal associated depression. Psychosocial factors also may increase risk of depression during menopause.
Conclusions
Menopause increases vulnerability to depression and anxiety, perhaps via estrogen fluctuations affecting serotonin and GABA. Underlying neuroticism and contemporaneous adverse life events are also risk factors for menopausal decompensation with depression.},
number = {2},
urldate = {2024-10-09},
journal = {Australasian Psychiatry},
author = {Alblooshi, Salama and Taylor, Mark and Gill, Neeraj},
month = apr,
year = {2023},
pmid = {36961547},
pmcid = {PMC10088347},
pages = {165--173},
}
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Methods Using PRISMA methodology, we conducted a systematic review of all published (in English) original data examining a relationship between menopause and depression and anxiety. We ranked the quality of all included studies using Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria. Results Twenty-two selected studies were summarized and compared, being eight cross-sectional surveys; one retrospective cohort, and 13 prospective cohort studies. Depression and anxiety are common during menopause and the post-menopause, with vasomotor symptoms and a prior history of major depression elevating risk of menopausal associated depression. Psychosocial factors also may increase risk of depression during menopause. Conclusions Menopause increases vulnerability to depression and anxiety, perhaps via estrogen fluctuations affecting serotonin and GABA. Underlying neuroticism and contemporaneous adverse life events are also risk factors for menopausal decompensation with depression.","number":"2","urldate":"2024-10-09","journal":"Australasian Psychiatry","author":[{"propositions":[],"lastnames":["Alblooshi"],"firstnames":["Salama"],"suffixes":[]},{"propositions":[],"lastnames":["Taylor"],"firstnames":["Mark"],"suffixes":[]},{"propositions":[],"lastnames":["Gill"],"firstnames":["Neeraj"],"suffixes":[]}],"month":"April","year":"2023","pmid":"36961547","pmcid":"PMC10088347","pages":"165–173","bibtex":"@article{alblooshi_does_2023,\n\ttitle = {Does menopause elevate the risk for developing depression and anxiety? {Results} from a systematic review},\n\tvolume = {31},\n\tissn = {1039-8562},\n\tshorttitle = {Does menopause elevate the risk for developing depression and anxiety?},\n\turl = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088347/},\n\tdoi = {10.1177/10398562231165439},\n\tabstract = {Objective\nTo determine whether menopause elevates the risk for developing diagnostic depression and anxiety. Menopause-associated vasomotor symptoms such as insomnia and hot flushes are well recognized, but no systematic review of the psychological consequences of menopause has been undertaken. Menopause can be a time of social change for women, confounding any correlation.\n\nMethods\nUsing PRISMA methodology, we conducted a systematic review of all published (in English) original data examining a relationship between menopause and depression and anxiety. We ranked the quality of all included studies using Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria.\n\nResults\nTwenty-two selected studies were summarized and compared, being eight cross-sectional surveys; one retrospective cohort, and 13 prospective cohort studies. Depression and anxiety are common during menopause and the post-menopause, with vasomotor symptoms and a prior history of major depression elevating risk of menopausal associated depression. Psychosocial factors also may increase risk of depression during menopause.\n\nConclusions\nMenopause increases vulnerability to depression and anxiety, perhaps via estrogen fluctuations affecting serotonin and GABA. Underlying neuroticism and contemporaneous adverse life events are also risk factors for menopausal decompensation with depression.},\n\tnumber = {2},\n\turldate = {2024-10-09},\n\tjournal = {Australasian Psychiatry},\n\tauthor = {Alblooshi, Salama and Taylor, Mark and Gill, Neeraj},\n\tmonth = apr,\n\tyear = {2023},\n\tpmid = {36961547},\n\tpmcid = {PMC10088347},\n\tpages = {165--173},\n}\n\n","author_short":["Alblooshi, S.","Taylor, M.","Gill, N."],"key":"alblooshi_does_2023","id":"alblooshi_does_2023","bibbaseid":"alblooshi-taylor-gill-doesmenopauseelevatetheriskfordevelopingdepressionandanxietyresultsfromasystematicreview-2023","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088347/"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/15071440/collections/5FRVUS3D/items?key=DYv3LhpkEzVkxKoHJpE9Wa69&format=bibtex&limit=100","dataSources":["uYhKHjqvDDXz4Baxk"],"keywords":[],"search_terms":["menopause","elevate","risk","developing","depression","anxiety","results","systematic","review","alblooshi","taylor","gill"],"title":"Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review","year":2023}