Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium. Aldape, K., Amin, S. B, Ashley, D. M, Barnholtz-Sloan, J. S, Bates, A. J, Beroukhim, R., Bock, C., Brat, D. J, Claus, E. B, Costello, J. F, de Groot, J. F, Finocchiaro, G., French, P. J, Gan, H. K, Griffith, B., Herold-Mende, C. C, Horbinski, C., Iavarone, A., Kalkanis, S. N, Karabatsou, K., Kim, H., Kouwenhoven, M. C M, McDonald, K. L, Miletic, H., Nam, D., Ng, H. K., Niclou, S. P, Noushmehr, H., Ormond, R., Poisson, L. M, Reifenberger, G., Roncaroli, F., Sa, J. K, Sillevis Smitt, P. A E, Smits, M., Souza, C. F, Tabatabai, G., Van Meir, E. G, Verhaak, R. G W, Watts, C., Wesseling, P., Woehrer, A., Yung, W K A., Jungk, C., Hau, A., van Dyck, E., Westerman, B. A, Yin, J., Abiola, O., Zeps, N., Grimmond, S., Buckland, M., Khasraw, M., Sulman, E. P, Muscat, A. M, & Stead, L. Neuro. Oncol., February, 2018.
Paper doi abstract bibtex Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas (TCGA) and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal AnalySiS Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities, and ultimately, improved outcomes for a patient population in need.
@ARTICLE{Aldape2018-qf,
title = "Glioma Through the Looking {GLASS}: Molecular Evolution of
Diffuse Gliomas and the Glioma Longitudinal {AnalySiS} Consortium",
author = "Aldape, Kenneth and Amin, Samirkumar B and Ashley, David M and
Barnholtz-Sloan, Jill S and Bates, Amanda J and Beroukhim, Rameen
and Bock, Christoph and Brat, Daniel J and Claus, Elizabeth B and
Costello, Joseph F and de Groot, John F and Finocchiaro, Gaetano
and French, Pim J and Gan, Hui K and Griffith, Brent and
Herold-Mende, Christel C and Horbinski, Craig and Iavarone,
Antonio and Kalkanis, Steven N and Karabatsou, Konstantina and
Kim, Hoon and Kouwenhoven, Mathilde C M and McDonald, Kerrie L
and Miletic, Hrvoje and Nam, Do-Hyun and Ng, Ho Keung and Niclou,
Simone P and Noushmehr, Houtan and Ormond, Ryan and Poisson,
Laila M and Reifenberger, Guido and Roncaroli, Federico and Sa,
Jason K and Sillevis Smitt, Peter A E and Smits, Marion and
Souza, Camila F and Tabatabai, Ghazaleh and Van Meir, Erwin G and
Verhaak, Roel G W and Watts, Colin and Wesseling, Pieter and
Woehrer, Adelheid and Yung, W K Alfred and Jungk, Christine and
Hau, Ann-Christin and van Dyck, Eric and Westerman, Bart A and
Yin, Julia and Abiola, Olajide and Zeps, Nikolaj and Grimmond,
Sean and Buckland, Michael and Khasraw, Mustafa and Sulman, Erik
P and Muscat, Andrea M and Stead, Lucy",
abstract = "Adult diffuse gliomas are a diverse group of brain neoplasms that
inflict a high emotional toll on patients and their families. The
Cancer Genome Atlas (TCGA) and similar projects have provided a
comprehensive understanding of the somatic alterations and
molecular subtypes of glioma at diagnosis. However, gliomas
undergo significant cellular and molecular evolution during
disease progression. We review the current knowledge on the
genomic and epigenetic abnormalities in primary tumors and after
disease recurrence, highlight the gaps in the literature, and
elaborate on the need for a new multi-institutional effort to
bridge these knowledge gaps and how the Glioma Longitudinal
AnalySiS Consortium (GLASS) aims to systemically catalog the
longitudinal changes in gliomas. The GLASS initiative will
provide essential insights into the evolution of glioma toward a
lethal phenotype, with the potential to reveal targetable
vulnerabilities, and ultimately, improved outcomes for a patient
population in need.",
journal = "Neuro. Oncol.",
month = feb,
year = 2018,
url = "https://academic.oup.com/neuro-oncology/advance-article-abstract/doi/10.1093/neuonc/noy020/4843984",
issn = "1522-8517",
doi = "10.1093/neuonc/noy020",
authorclass = {coauthor},
contribution = {data\_analysis},
affiliation = {JAX}
}
Downloads: 0
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diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas (TCGA) and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal AnalySiS Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities, and ultimately, improved outcomes for a patient population in need.","journal":"Neuro. Oncol.","month":"February","year":"2018","url":"https://academic.oup.com/neuro-oncology/advance-article-abstract/doi/10.1093/neuonc/noy020/4843984","issn":"1522-8517","doi":"10.1093/neuonc/noy020","authorclass":"coauthor","contribution":"data_analysis","affiliation":"JAX","bibtex":"@ARTICLE{Aldape2018-qf,\n title = \"Glioma Through the Looking {GLASS}: Molecular Evolution of\n Diffuse Gliomas and the Glioma Longitudinal {AnalySiS} Consortium\",\n author = \"Aldape, Kenneth and Amin, Samirkumar B and Ashley, David M and\n Barnholtz-Sloan, Jill S and Bates, Amanda J and Beroukhim, Rameen\n and Bock, Christoph and Brat, Daniel J and Claus, Elizabeth B and\n Costello, Joseph F and de Groot, John F and Finocchiaro, Gaetano\n and French, Pim J and Gan, Hui K and Griffith, Brent and\n Herold-Mende, Christel C and Horbinski, Craig and Iavarone,\n Antonio and Kalkanis, Steven N and Karabatsou, Konstantina and\n Kim, Hoon and Kouwenhoven, Mathilde C M and McDonald, Kerrie L\n and Miletic, Hrvoje and Nam, Do-Hyun and Ng, Ho Keung and Niclou,\n Simone P and Noushmehr, Houtan and Ormond, Ryan and Poisson,\n Laila M and Reifenberger, Guido and Roncaroli, Federico and Sa,\n Jason K and Sillevis Smitt, Peter A E and Smits, Marion and\n Souza, Camila F and Tabatabai, Ghazaleh and Van Meir, Erwin G and\n Verhaak, Roel G W and Watts, Colin and Wesseling, Pieter and\n Woehrer, Adelheid and Yung, W K Alfred and Jungk, Christine and\n Hau, Ann-Christin and van Dyck, Eric and Westerman, Bart A and\n Yin, Julia and Abiola, Olajide and Zeps, Nikolaj and Grimmond,\n Sean and Buckland, Michael and Khasraw, Mustafa and Sulman, Erik\n P and Muscat, Andrea M and Stead, Lucy\",\n abstract = \"Adult diffuse gliomas are a diverse group of brain neoplasms that\n inflict a high emotional toll on patients and their families. The\n Cancer Genome Atlas (TCGA) and similar projects have provided a\n comprehensive understanding of the somatic alterations and\n molecular subtypes of glioma at diagnosis. However, gliomas\n undergo significant cellular and molecular evolution during\n disease progression. We review the current knowledge on the\n genomic and epigenetic abnormalities in primary tumors and after\n disease recurrence, highlight the gaps in the literature, and\n elaborate on the need for a new multi-institutional effort to\n bridge these knowledge gaps and how the Glioma Longitudinal\n AnalySiS Consortium (GLASS) aims to systemically catalog the\n longitudinal changes in gliomas. The GLASS initiative will\n provide essential insights into the evolution of glioma toward a\n lethal phenotype, with the potential to reveal targetable\n vulnerabilities, and ultimately, improved outcomes for a patient\n population in need.\",\n journal = \"Neuro. 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