Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium. Aldape, K., Amin, S. B, Ashley, D. M, Barnholtz-Sloan, J. S, Bates, A. J, Beroukhim, R., Bock, C., Brat, D. J, Claus, E. B, Costello, J. F, de Groot, J. F, Finocchiaro, G., French, P. J, Gan, H. K, Griffith, B., Herold-Mende, C. C, Horbinski, C., Iavarone, A., Kalkanis, S. N, Karabatsou, K., Kim, H., Kouwenhoven, M. C M, McDonald, K. L, Miletic, H., Nam, D., Ng, H. K., Niclou, S. P, Noushmehr, H., Ormond, R., Poisson, L. M, Reifenberger, G., Roncaroli, F., Sa, J. K, Sillevis Smitt, P. A E, Smits, M., Souza, C. F, Tabatabai, G., Van Meir, E. G, Verhaak, R. G W, Watts, C., Wesseling, P., Woehrer, A., Yung, W K A., Jungk, C., Hau, A., van Dyck, E., Westerman, B. A, Yin, J., Abiola, O., Zeps, N., Grimmond, S., Buckland, M., Khasraw, M., Sulman, E. P, Muscat, A. M, & Stead, L. Neuro. Oncol., February, 2018.
Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium [link]Paper  doi  abstract   bibtex   
Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas (TCGA) and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal AnalySiS Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities, and ultimately, improved outcomes for a patient population in need.
@ARTICLE{Aldape2018-qf,
  title    = "Glioma Through the Looking {GLASS}: Molecular Evolution of
              Diffuse Gliomas and the Glioma Longitudinal {AnalySiS} Consortium",
  author   = "Aldape, Kenneth and Amin, Samirkumar B and Ashley, David M and
              Barnholtz-Sloan, Jill S and Bates, Amanda J and Beroukhim, Rameen
              and Bock, Christoph and Brat, Daniel J and Claus, Elizabeth B and
              Costello, Joseph F and de Groot, John F and Finocchiaro, Gaetano
              and French, Pim J and Gan, Hui K and Griffith, Brent and
              Herold-Mende, Christel C and Horbinski, Craig and Iavarone,
              Antonio and Kalkanis, Steven N and Karabatsou, Konstantina and
              Kim, Hoon and Kouwenhoven, Mathilde C M and McDonald, Kerrie L
              and Miletic, Hrvoje and Nam, Do-Hyun and Ng, Ho Keung and Niclou,
              Simone P and Noushmehr, Houtan and Ormond, Ryan and Poisson,
              Laila M and Reifenberger, Guido and Roncaroli, Federico and Sa,
              Jason K and Sillevis Smitt, Peter A E and Smits, Marion and
              Souza, Camila F and Tabatabai, Ghazaleh and Van Meir, Erwin G and
              Verhaak, Roel G W and Watts, Colin and Wesseling, Pieter and
              Woehrer, Adelheid and Yung, W K Alfred and Jungk, Christine and
              Hau, Ann-Christin and van Dyck, Eric and Westerman, Bart A and
              Yin, Julia and Abiola, Olajide and Zeps, Nikolaj and Grimmond,
              Sean and Buckland, Michael and Khasraw, Mustafa and Sulman, Erik
              P and Muscat, Andrea M and Stead, Lucy",
  abstract = "Adult diffuse gliomas are a diverse group of brain neoplasms that
              inflict a high emotional toll on patients and their families. The
              Cancer Genome Atlas (TCGA) and similar projects have provided a
              comprehensive understanding of the somatic alterations and
              molecular subtypes of glioma at diagnosis. However, gliomas
              undergo significant cellular and molecular evolution during
              disease progression. We review the current knowledge on the
              genomic and epigenetic abnormalities in primary tumors and after
              disease recurrence, highlight the gaps in the literature, and
              elaborate on the need for a new multi-institutional effort to
              bridge these knowledge gaps and how the Glioma Longitudinal
              AnalySiS Consortium (GLASS) aims to systemically catalog the
              longitudinal changes in gliomas. The GLASS initiative will
              provide essential insights into the evolution of glioma toward a
              lethal phenotype, with the potential to reveal targetable
              vulnerabilities, and ultimately, improved outcomes for a patient
              population in need.",
  journal  = "Neuro. Oncol.",
  month    =  feb,
  year     =  2018,
  url      = "https://academic.oup.com/neuro-oncology/advance-article-abstract/doi/10.1093/neuonc/noy020/4843984",
  issn     = "1522-8517",
  doi      = "10.1093/neuonc/noy020",
  authorclass = {coauthor},
  contribution = {data\_analysis},
  affiliation = {JAX}
}

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