@article{RN320,
   author = {Alers, R. J. and Ghossein-Doha, C. and Canjels, L. P. W. and Muijtjens, E. S. H. and Brandt, Y. and Kooi, M. E. and Gerretsen, S. C. and Jansen, J. F. A. and Backes, W. H. and Hurks, P. P. M. and van de Ven, V. and Spaanderman, M. E. A.},
   title = {Attenuated cognitive functioning decades after preeclampsia},
   journal = {Am J Obstet Gynecol},
   note = {Alers, R J
Ghossein-Doha, C
Canjels, L P W
Muijtjens, E S H
Brandt, Y
Kooi, M E
Gerretsen, S C
Jansen, J F A
Backes, W H
Hurks, P P M
van de Ven, V
Spaanderman, M E A
eng
Am J Obstet Gynecol. 2023 Feb 28:S0002-9378(23)00136-9. doi: 10.1016/j.ajog.2023.02.020.},
   abstract = {BACKGROUND: Preeclampsia, a hypertensive pregnancy disorder, is a leading cause of maternal and fetal morbidity and mortality with remote cardio- and cerebrovascular implications. After preeclampsia, women may report serious disabling cognitive complaints, especially involving executive function, but the extent and time course of these complaints are unknown. OBJECTIVE: This study aimed to determine the impact of preeclampsia on perceived maternal cognitive functioning decades after pregnancy. STUDY DESIGN: This study is part of a cross-sectional case control study named Queen of Hearts (ClinicalTrials.gov Identifier: NCT02347540), a collaboration study of five tertiary referral centers within the Netherlands investigating long-term effects of preeclampsia. Eligible participants were females aged >/=18 years after preeclampsia and after normotensive pregnancy between six months and 30 years after their first (complicated) pregnancy. Preeclampsia was defined as new-onset hypertension after 20 weeks of gestation along with proteinuria, fetal growth restriction, or other maternal organ dysfunction. Women with a history of hypertension, autoimmune disease, or kidney disease prior to their first pregnancy were excluded. Attenuation of higher-order cognitive functions, i.e., executive function, was measured with the Behavior Rating Inventory of Executive Function for Adults. Crude and covariate-adjusted absolute and relative risks of clinical attenuation over time after (complicated) pregnancy were determined with moderated logistic and log-binomial regression. RESULTS: This study included 1036 women with a history of preeclampsia and 527 women with normotensive pregnancies. Regarding overall executive function, 23.2% (95%-confidence interval 19.0 to 28.1%) of women experienced clinically significant attenuation after preeclampsia compared to 2.2% (95%-confidence interval 0.8 to 6.0%) of controls just after childbirth; adjusted relative risk of 9.20 (95%-confidence interval 3.33 to 25.38). Group differences diminished yet remained statistically significant at least 19 years postpartum. Regardless of a history of preeclampsia, women with lower educational attainment, mood or anxiety disorders, or obesity were especially at risk. Neither severity of preeclampsia, multiple gestation, method of delivery, preterm birth, nor perinatal death related to overall executive function. CONCLUSION: After preeclampsia, women were nine times more likely to experience clinical attenuation of higher-order cognitive functions as compared to after normotensive pregnancy. Despite overall steady improvement, elevated risks persisted over decades after childbirth.},
   keywords = {cognition
executive function
long-term effect
maternal health
obstetric complication
postpartum
preeclampsia
working memory},
   ISSN = {1097-6868 (Electronic)
0002-9378 (Linking)},
   DOI = {10.1016/j.ajog.2023.02.020},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/36863645},
   year = {2023},
   type = {Journal Article}
}

{"_id":"iSRy9WkZi8CNLBGbo","bibbaseid":"alers-ghosseindoha-canjels-muijtjens-brandt-kooi-gerretsen-jansen-etal-attenuatedcognitivefunctioningdecadesafterpreeclampsia-2023","author_short":["Alers, R. J.","Ghossein-Doha, C.","Canjels, L. P. W.","Muijtjens, E. S. H.","Brandt, Y.","Kooi, M. E.","Gerretsen, S. C.","Jansen, J. F. A.","Backes, W. H.","Hurks, P. P. M.","van de Ven, V.","Spaanderman, M. E. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Alers"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Ghossein-Doha"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Canjels"],"firstnames":["L.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Muijtjens"],"firstnames":["E.","S.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Brandt"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Kooi"],"firstnames":["M.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Gerretsen"],"firstnames":["S.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Hurks"],"firstnames":["P.","P.","M."],"suffixes":[]},{"propositions":["van","de"],"lastnames":["Ven"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Spaanderman"],"firstnames":["M.","E.","A."],"suffixes":[]}],"title":"Attenuated cognitive functioning decades after preeclampsia","journal":"Am J Obstet Gynecol","note":"Alers, R J Ghossein-Doha, C Canjels, L P W Muijtjens, E S H Brandt, Y Kooi, M E Gerretsen, S C Jansen, J F A Backes, W H Hurks, P P M van de Ven, V Spaanderman, M E A eng Am J Obstet Gynecol. 2023 Feb 28:S0002-9378(23)00136-9. doi: 10.1016/j.ajog.2023.02.020.","abstract":"BACKGROUND: Preeclampsia, a hypertensive pregnancy disorder, is a leading cause of maternal and fetal morbidity and mortality with remote cardio- and cerebrovascular implications. After preeclampsia, women may report serious disabling cognitive complaints, especially involving executive function, but the extent and time course of these complaints are unknown. OBJECTIVE: This study aimed to determine the impact of preeclampsia on perceived maternal cognitive functioning decades after pregnancy. STUDY DESIGN: This study is part of a cross-sectional case control study named Queen of Hearts (ClinicalTrials.gov Identifier: NCT02347540), a collaboration study of five tertiary referral centers within the Netherlands investigating long-term effects of preeclampsia. Eligible participants were females aged >/=18 years after preeclampsia and after normotensive pregnancy between six months and 30 years after their first (complicated) pregnancy. Preeclampsia was defined as new-onset hypertension after 20 weeks of gestation along with proteinuria, fetal growth restriction, or other maternal organ dysfunction. Women with a history of hypertension, autoimmune disease, or kidney disease prior to their first pregnancy were excluded. Attenuation of higher-order cognitive functions, i.e., executive function, was measured with the Behavior Rating Inventory of Executive Function for Adults. Crude and covariate-adjusted absolute and relative risks of clinical attenuation over time after (complicated) pregnancy were determined with moderated logistic and log-binomial regression. RESULTS: This study included 1036 women with a history of preeclampsia and 527 women with normotensive pregnancies. Regarding overall executive function, 23.2% (95%-confidence interval 19.0 to 28.1%) of women experienced clinically significant attenuation after preeclampsia compared to 2.2% (95%-confidence interval 0.8 to 6.0%) of controls just after childbirth; adjusted relative risk of 9.20 (95%-confidence interval 3.33 to 25.38). Group differences diminished yet remained statistically significant at least 19 years postpartum. Regardless of a history of preeclampsia, women with lower educational attainment, mood or anxiety disorders, or obesity were especially at risk. Neither severity of preeclampsia, multiple gestation, method of delivery, preterm birth, nor perinatal death related to overall executive function. CONCLUSION: After preeclampsia, women were nine times more likely to experience clinical attenuation of higher-order cognitive functions as compared to after normotensive pregnancy. Despite overall steady improvement, elevated risks persisted over decades after childbirth.","keywords":"cognition executive function long-term effect maternal health obstetric complication postpartum preeclampsia working memory","issn":"1097-6868 (Electronic) 0002-9378 (Linking)","doi":"10.1016/j.ajog.2023.02.020","url":"https://www.ncbi.nlm.nih.gov/pubmed/36863645","year":"2023","bibtex":"@article{RN320,\n author = {Alers, R. J. and Ghossein-Doha, C. and Canjels, L. P. W. and Muijtjens, E. S. H. and Brandt, Y. and Kooi, M. E. and Gerretsen, S. C. and Jansen, J. F. A. and Backes, W. H. and Hurks, P. P. M. and van de Ven, V. and Spaanderman, M. E. A.},\n title = {Attenuated cognitive functioning decades after preeclampsia},\n journal = {Am J Obstet Gynecol},\n note = {Alers, R J\nGhossein-Doha, C\nCanjels, L P W\nMuijtjens, E S H\nBrandt, Y\nKooi, M E\nGerretsen, S C\nJansen, J F A\nBackes, W H\nHurks, P P M\nvan de Ven, V\nSpaanderman, M E A\neng\nAm J Obstet Gynecol. 2023 Feb 28:S0002-9378(23)00136-9. doi: 10.1016/j.ajog.2023.02.020.},\n abstract = {BACKGROUND: Preeclampsia, a hypertensive pregnancy disorder, is a leading cause of maternal and fetal morbidity and mortality with remote cardio- and cerebrovascular implications. After preeclampsia, women may report serious disabling cognitive complaints, especially involving executive function, but the extent and time course of these complaints are unknown. OBJECTIVE: This study aimed to determine the impact of preeclampsia on perceived maternal cognitive functioning decades after pregnancy. STUDY DESIGN: This study is part of a cross-sectional case control study named Queen of Hearts (ClinicalTrials.gov Identifier: NCT02347540), a collaboration study of five tertiary referral centers within the Netherlands investigating long-term effects of preeclampsia. Eligible participants were females aged >/=18 years after preeclampsia and after normotensive pregnancy between six months and 30 years after their first (complicated) pregnancy. Preeclampsia was defined as new-onset hypertension after 20 weeks of gestation along with proteinuria, fetal growth restriction, or other maternal organ dysfunction. Women with a history of hypertension, autoimmune disease, or kidney disease prior to their first pregnancy were excluded. Attenuation of higher-order cognitive functions, i.e., executive function, was measured with the Behavior Rating Inventory of Executive Function for Adults. Crude and covariate-adjusted absolute and relative risks of clinical attenuation over time after (complicated) pregnancy were determined with moderated logistic and log-binomial regression. RESULTS: This study included 1036 women with a history of preeclampsia and 527 women with normotensive pregnancies. Regarding overall executive function, 23.2% (95%-confidence interval 19.0 to 28.1%) of women experienced clinically significant attenuation after preeclampsia compared to 2.2% (95%-confidence interval 0.8 to 6.0%) of controls just after childbirth; adjusted relative risk of 9.20 (95%-confidence interval 3.33 to 25.38). Group differences diminished yet remained statistically significant at least 19 years postpartum. Regardless of a history of preeclampsia, women with lower educational attainment, mood or anxiety disorders, or obesity were especially at risk. Neither severity of preeclampsia, multiple gestation, method of delivery, preterm birth, nor perinatal death related to overall executive function. CONCLUSION: After preeclampsia, women were nine times more likely to experience clinical attenuation of higher-order cognitive functions as compared to after normotensive pregnancy. Despite overall steady improvement, elevated risks persisted over decades after childbirth.},\n keywords = {cognition\nexecutive function\nlong-term effect\nmaternal health\nobstetric complication\npostpartum\npreeclampsia\nworking memory},\n ISSN = {1097-6868 (Electronic)\n0002-9378 (Linking)},\n DOI = {10.1016/j.ajog.2023.02.020},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/36863645},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["Alers, R. J.","Ghossein-Doha, C.","Canjels, L. P. W.","Muijtjens, E. S. H.","Brandt, Y.","Kooi, M. E.","Gerretsen, S. C.","Jansen, J. F. A.","Backes, W. H.","Hurks, P. P. M.","van de Ven, V.","Spaanderman, M. E. 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