Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Alexandre-Gouabau, M., Moyon, T., Cariou, V., Antignac, J., Qannari, E., Croyal, M., Soumah, M., Guitton, Y., David-Sochard, A., Billard, H., Legrand, A., Boscher, C., Darmaun, D., Rozé, J., & Boquien, C. 10(2):164.
Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants [link]Paper  doi  abstract   bibtex   
Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother’s milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother’s breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced “slower” (n = 15, −1.54 ± 0.42 Z-score) or “faster” (n = 11, −0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the “faster-growth” group (0.56 ± 0.72 vs. −1.59 ± 0.96). Liquid chromatography–mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and ROC (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies.
@article{alexandre-gouabau_breast_2018,
	title = {Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants},
	volume = {10},
	issn = {2072-6643},
	url = {http://www.mdpi.com/2072-6643/10/2/164},
	doi = {10.3390/nu10020164},
	abstract = {Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother’s milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother’s breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced “slower” (n = 15, −1.54 ± 0.42 Z-score) or “faster” (n = 11, −0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the “faster-growth” group (0.56 ± 0.72 vs. −1.59 ± 0.96). Liquid chromatography–mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and {ROC} (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid ({DGLA})-containing phosphethanolamine, and less oleic acid-containing triglyceride and {DGLA}-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies.},
	pages = {164},
	number = {2},
	journaltitle = {Nutrients},
	author = {Alexandre-Gouabau, Marie-Cécile and Moyon, Thomas and Cariou, Véronique and Antignac, Jean-Philippe and Qannari, El and Croyal, Mikaël and Soumah, Mohamed and Guitton, Yann and David-Sochard, Agnès and Billard, Hélène and Legrand, Arnaud and Boscher, Cécile and Darmaun, Dominique and Rozé, Jean-Christophe and Boquien, Clair-Yves},
	urldate = {2019-03-29},
	date = {2018-01-31},
	langid = {english},
	file = {Alexandre-Gouabau et al. - 2018 - Breast Milk Lipidome Is Associated with Early Grow.pdf:C\:\\Users\\ygu\\Documents\\PCPOR066_YGU\\YGU\\Zotero\\storage\\34WAYM6Z\\Alexandre-Gouabau et al. - 2018 - Breast Milk Lipidome Is Associated with Early Grow.pdf:application/pdf}
}
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