Enhanced airway sensory nerve reactivity in non-eosinophilic asthma. Ali, H., Brooks, C., Crane, J., Beasley, R., Holgate, S., Gibson, P., Pattemore, P., Tzeng, Y., Stanley, T., Pearce, N., & Douwes, J. BMJ Open Respiratory Research, 8(1):e000974, November, 2021. ![Enhanced airway sensory nerve reactivity in non-eosinophilic asthma [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics. Methods Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5%. Airway hyperreactivity was defined as a ≥15% drop in FEV 1 during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs. Results Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p\textless0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV 1 was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed. Conclusion NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.
@article{ali_enhanced_2021,
title = {Enhanced airway sensory nerve reactivity in non-eosinophilic asthma},
volume = {8},
issn = {2052-4439},
url = {https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974},
doi = {10.1136/bmjresp-2021-000974},
abstract = {Background
Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics.
Methods
Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5\%. Airway hyperreactivity was defined as a ≥15\% drop in FEV
1
during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs.
Results
Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95\% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p{\textless}0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV
1
was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed.
Conclusion
NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.},
language = {en},
number = {1},
urldate = {2022-03-27},
journal = {BMJ Open Respiratory Research},
author = {Ali, Hajar and Brooks, Collin and Crane, Julian and Beasley, Richard and Holgate, Stephen and Gibson, Peter and Pattemore, Philip and Tzeng, Yu-Chieh and Stanley, Thorsten and Pearce, Neil and Douwes, Jeroen},
month = nov,
year = {2021},
pages = {e000974},
}
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{"_id":"3zaZ3CNtbPZkka2nu","bibbaseid":"ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021","author_short":["Ali, H.","Brooks, C.","Crane, J.","Beasley, R.","Holgate, S.","Gibson, P.","Pattemore, P.","Tzeng, Y.","Stanley, T.","Pearce, N.","Douwes, J."],"bibdata":{"bibtype":"article","type":"article","title":"Enhanced airway sensory nerve reactivity in non-eosinophilic asthma","volume":"8","issn":"2052-4439","url":"https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974","doi":"10.1136/bmjresp-2021-000974","abstract":"Background Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics. Methods Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5%. Airway hyperreactivity was defined as a ≥15% drop in FEV 1 during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs. Results Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p\\textless0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV 1 was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed. Conclusion NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.","language":"en","number":"1","urldate":"2022-03-27","journal":"BMJ Open Respiratory Research","author":[{"propositions":[],"lastnames":["Ali"],"firstnames":["Hajar"],"suffixes":[]},{"propositions":[],"lastnames":["Brooks"],"firstnames":["Collin"],"suffixes":[]},{"propositions":[],"lastnames":["Crane"],"firstnames":["Julian"],"suffixes":[]},{"propositions":[],"lastnames":["Beasley"],"firstnames":["Richard"],"suffixes":[]},{"propositions":[],"lastnames":["Holgate"],"firstnames":["Stephen"],"suffixes":[]},{"propositions":[],"lastnames":["Gibson"],"firstnames":["Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Pattemore"],"firstnames":["Philip"],"suffixes":[]},{"propositions":[],"lastnames":["Tzeng"],"firstnames":["Yu-Chieh"],"suffixes":[]},{"propositions":[],"lastnames":["Stanley"],"firstnames":["Thorsten"],"suffixes":[]},{"propositions":[],"lastnames":["Pearce"],"firstnames":["Neil"],"suffixes":[]},{"propositions":[],"lastnames":["Douwes"],"firstnames":["Jeroen"],"suffixes":[]}],"month":"November","year":"2021","pages":"e000974","bibtex":"@article{ali_enhanced_2021,\n\ttitle = {Enhanced airway sensory nerve reactivity in non-eosinophilic asthma},\n\tvolume = {8},\n\tissn = {2052-4439},\n\turl = {https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974},\n\tdoi = {10.1136/bmjresp-2021-000974},\n\tabstract = {Background\n Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics.\n \n \n Methods\n \n Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5\\%. Airway hyperreactivity was defined as a ≥15\\% drop in FEV\n 1\n during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs.\n \n \n \n Results\n \n Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95\\% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p{\\textless}0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV\n 1\n was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed.\n \n \n \n Conclusion\n NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-03-27},\n\tjournal = {BMJ Open Respiratory Research},\n\tauthor = {Ali, Hajar and Brooks, Collin and Crane, Julian and Beasley, Richard and Holgate, Stephen and Gibson, Peter and Pattemore, Philip and Tzeng, Yu-Chieh and Stanley, Thorsten and Pearce, Neil and Douwes, Jeroen},\n\tmonth = nov,\n\tyear = {2021},\n\tpages = {e000974},\n}\n\n","author_short":["Ali, H.","Brooks, C.","Crane, J.","Beasley, R.","Holgate, S.","Gibson, P.","Pattemore, P.","Tzeng, Y.","Stanley, T.","Pearce, N.","Douwes, J."],"key":"ali_enhanced_2021","id":"ali_enhanced_2021","bibbaseid":"ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021","role":"author","urls":{"Paper":"https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/6607533/collections/EUK4Z2Y3/items?key=hGXLq241MCQA3ow7rlTIV2gY&format=bibtex&limit=100","dataSources":["ydy8iPhP2TsFttgY7","g6GzqSeiNQrL4uwxq","6SkqXiGdfnEhkfeWg","gYp5LQXkoiKhbuLwC","BvvFw2zRfGrfhQ6x4","ZJ4j4Apddh3MpQnDj"],"keywords":[],"search_terms":["enhanced","airway","sensory","nerve","reactivity","non","eosinophilic","asthma","ali","brooks","crane","beasley","holgate","gibson","pattemore","tzeng","stanley","pearce","douwes"],"title":"Enhanced airway sensory nerve reactivity in non-eosinophilic asthma","year":2021}