(18) F-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of recurrent bone and soft tissue sarcoma. Al-Ibraheem, A., Buck, A. K., Benz, M. R., Rudert, M., Beer, A. J., Mansour, A., Pomykala, K. L., Haller, B., Juenger, H., Scheidhauer, K., Schwaiger, M., & Herrmann, K. Cancer, 119(6):1227–1234, March, 2013.
doi  abstract   bibtex   
BACKGROUND: The clinical utility of modern hybrid imaging modalities for detecting recurrent bone or soft tissue sarcoma remains to be determined. In this report, the authors present a clinical study on the diagnostic accuracy and incremental value of integrated (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT) in patients with a history of sarcoma who have clinically suspected disease recurrence. METHODS: Forty-three patients who had a history of bone or soft tissue sarcoma and had documented complete remission underwent (18) F-FDG PET/CT. Image analysis was performed independently for (18) F-FDG PET (n = 43) and for contrast-enhanced spiral CT (CE-CT) (n = 30) by 2 separate readers, whereas combined (18) F-FDG PET/CT (n = 43) images were analyzed in consensus by both readers. Imaging findings were rated on a 5-point scale and finally were reported as malignant, benign, or equivocal. Imaging findings were validated either by histopathology (n = 24) or by clinical follow-up (n = 19). RESULTS: (18) F-FDG PET/CT had greater sensitivity and specificity compared with CE-CT alone (94% and 92% vs 78% and 67%, respectively), resulting in significantly greater accuracy (93% vs 73%; P = .03). (18) F-FDG PET/CT was particularly superior regarding detection of local recurrence or soft tissue lesions (sensitivity and specificity: 83% and 100% vs 50% and 100%, respectively) or bone metastases (100% and 100% vs 85% and 88%, respectively). CONCLUSIONS: (18) F-FDG PET/CT had greater diagnostic accuracy in the detection of recurrent bone or soft tissue sarcoma compared with CE-CT alone. The detection of local recurrence was the most evident advantage of (18) F-FDG PET/CT over CE-CT. Cancer 2013. (c) 2012 American Cancer Society.
@article{al-ibraheem_18_2013,
	title = {(18) {F}-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of recurrent bone and soft tissue sarcoma.},
	volume = {119},
	copyright = {Copyright (c) 2012 American Cancer Society.},
	doi = {10.1002/cncr.27866},
	abstract = {BACKGROUND: The clinical utility of modern hybrid imaging modalities for detecting recurrent bone or soft tissue sarcoma remains to be determined. In this report, the authors present a clinical study on the diagnostic accuracy and incremental value of integrated (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT) in patients with a history of  sarcoma who have clinically suspected disease recurrence. METHODS: Forty-three patients who had a history of bone or soft tissue sarcoma and had documented complete remission underwent (18) F-FDG PET/CT. Image analysis was performed independently for (18) F-FDG PET (n = 43) and for contrast-enhanced spiral CT (CE-CT) (n = 30) by 2 separate readers, whereas combined (18) F-FDG PET/CT (n = 43) images were analyzed in consensus by both readers. Imaging findings were rated on a 5-point scale and finally were reported as malignant, benign, or equivocal. Imaging findings were validated either by histopathology (n = 24) or by clinical follow-up (n = 19). RESULTS: (18) F-FDG PET/CT had greater sensitivity and specificity compared with CE-CT alone (94\% and 92\% vs 78\% and 67\%, respectively), resulting in significantly greater accuracy (93\% vs 73\%; P =  .03). (18) F-FDG PET/CT was particularly superior regarding detection of local recurrence or soft tissue lesions (sensitivity and specificity: 83\% and 100\% vs 50\% and 100\%, respectively) or bone metastases (100\% and 100\% vs 85\% and 88\%, respectively). CONCLUSIONS: (18) F-FDG PET/CT had greater diagnostic accuracy in  the detection of recurrent bone or soft tissue sarcoma compared with CE-CT alone. The detection of local recurrence was the most evident advantage of (18) F-FDG PET/CT over CE-CT. Cancer 2013. (c) 2012 American Cancer Society.},
	language = {eng},
	number = {6},
	journal = {Cancer},
	author = {Al-Ibraheem, Akram and Buck, Andreas K. and Benz, Matthias R. and Rudert, Maximilian and Beer, Ambros J. and Mansour, Asem and Pomykala, Kelsey L. and Haller, Bernhard and Juenger, Hendrik and Scheidhauer, Klemens and Schwaiger, Markus and Herrmann, Ken},
	month = mar,
	year = {2013},
	pmid = {23233156},
	keywords = {*Multimodal Imaging, *Positron-Emission Tomography, Adolescent, Adult, Aged, Aged, 80 and over, Bone Neoplasms/*diagnosis/pathology, Contrast Media, Female, Fluorodeoxyglucose F18/diagnostic use, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/diagnosis, Sarcoma/*diagnosis/pathology, Sensitivity and Specificity, Tomography, X-Ray Computed/methods, Young Adult},
	pages = {1227--1234},
}

Downloads: 0