@article{ WOS:000207459000019,
Author = {Al-Sakere, Bassim and Andre, Franck and Bernat, Claire and Connault,
   Elisabeth and Opolon, Paule and Davalos, Rafael V. and Rubinsky, Boris
   and Mir, Lluis M.},
Title = {Tumor Ablation with Irreversible Electroporation},
Journal = {PLOS ONE},
Year = {2007},
Volume = {2},
Number = {11},
Month = {NOV 7},
Abstract = {We report the first successful use of irreversible electroporation for
   the minimally invasive treatment of aggressive cutaneous tumors
   implanted in mice. Irreversible electroporation is a newly developed
   non-thermal tissue ablation technique in which certain short duration
   electrical fields are used to permanently permeabilize the cell
   membrane, presumably through the formation of nanoscale defects in the
   cell membrane. Mathematical models of the electrical and thermal fields
   that develop during the application of the pulses were used to design an
   efficient treatment protocol with minimal heating of the tissue. Tumor
   regression was confirmed by histological studies which also revealed
   that it occurred as a direct result of irreversible cell membrane
   permeabilization. Parametric studies show that the successful outcome of
   the procedure is related to the applied electric field strength, the
   total pulse duration as well as the temporal mode of delivery of the
   pulses. Our best results were obtained using plate electrodes to deliver
   across the tumor 80 pulses of 100 mu s at 0.3 Hz with an electrical
   field magnitude of 2500 V/cm. These conditions induced complete
   regression in 12 out of 13 treated tumors, (92\%), in the absence of
   tissue heating. Irreversible electroporation is thus a new effective
   modality for non-thermal tumor ablation.},
Publisher = {PUBLIC LIBRARY SCIENCE},
Address = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA},
Type = {Article},
Language = {English},
Affiliation = {Mir, LM (Corresponding Author), Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France.
   Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Mir, Lluis M., Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France.
   Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Mir, Lluis M., Univ Paris Sud, UMR 8121, Villejuif, France.
   Davalos, Rafael V., Virginia Tech Wake Forest Univ, Sch Biomed Engn \& Sci, Blacksburg, VA USA.
   Rubinsky, Boris, Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA.
   Rubinsky, Boris, Univ Calif Berkeley, Grad Program Biophys, Berkeley, CA 94720 USA.
   Rubinsky, Boris, Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA.
   Rubinsky, Boris, Hebrew Univ Jerusalem, Sch Comp Sci \& Engn, Ctr Bioengn Serv Humanity \& Soc, Jerusalem, Israel.},
DOI = {10.1371/journal.pone.0001135},
Article-Number = {e1135},
ISSN = {1932-6203},
Research-Areas = {Science \& Technology - Other Topics},
Web-of-Science-Categories  = {Multidisciplinary Sciences},
Author-Email = {luismir@igr.fr},
Affiliations = {Centre National de la Recherche Scientifique (CNRS); UNICANCER; Gustave
   Roussy; Universite Paris Saclay; Virginia Polytechnic Institute \& State
   University; University of California System; University of California
   Berkeley; University of California System; University of California
   Berkeley; University of California System; University of California
   Berkeley; Hebrew University of Jerusalem},
ResearcherID-Numbers = {Rubinsky, Boris/B-4439-2010
   MIR, Lluis M/AAJ-9110-2020
   Davalos, Rafael V/F-9012-2011
   Sano, Michael B/E-1715-2011
   },
ORCID-Numbers = {, Lluis/0000-0002-8671-9467},
Funding-Acknowledgement = {CNRS; IGR; U. S. National Institutes of Health (NIH) {[}NIH R01
   RR018961]},
Funding-Text = {This work was supported by grants of CNRS and IGR. BR was supported in
   part by the U. S. National Institutes of Health (NIH) under Grant NIH
   R01 RR018961. The sponsors had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.},
Number-of-Cited-References = {44},
Times-Cited = {358},
Usage-Count-Last-180-days = {1},
Usage-Count-Since-2013 = {33},
Journal-ISO = {PLoS One},
Doc-Delivery-Number = {V10IZ},
Web-of-Science-Index = {Science Citation Index Expanded (SCI-EXPANDED)},
Unique-ID = {WOS:000207459000019},
OA = {gold, Green Published},
DA = {2024-03-03},
}

{"_id":"pFfANJMcTNgCegMFQ","bibbaseid":"alsakere-andre-bernat-connault-opolon-davalos-rubinsky-mir-tumorablationwithirreversibleelectroporation-2007","author_short":["Al-Sakere, B.","Andre, F.","Bernat, C.","Connault, E.","Opolon, P.","Davalos, R. V.","Rubinsky, B.","Mir, L. M."],"bibdata":{"bibtype":"article","type":"Article","author":[{"propositions":[],"lastnames":["Al-Sakere"],"firstnames":["Bassim"],"suffixes":[]},{"propositions":[],"lastnames":["Andre"],"firstnames":["Franck"],"suffixes":[]},{"propositions":[],"lastnames":["Bernat"],"firstnames":["Claire"],"suffixes":[]},{"propositions":[],"lastnames":["Connault"],"firstnames":["Elisabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Opolon"],"firstnames":["Paule"],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["Rafael","V."],"suffixes":[]},{"propositions":[],"lastnames":["Rubinsky"],"firstnames":["Boris"],"suffixes":[]},{"propositions":[],"lastnames":["Mir"],"firstnames":["Lluis","M."],"suffixes":[]}],"title":"Tumor Ablation with Irreversible Electroporation","journal":"PLOS ONE","year":"2007","volume":"2","number":"11","month":"NOV 7","abstract":"We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the cell membrane. Mathematical models of the electrical and thermal fields that develop during the application of the pulses were used to design an efficient treatment protocol with minimal heating of the tissue. Tumor regression was confirmed by histological studies which also revealed that it occurred as a direct result of irreversible cell membrane permeabilization. Parametric studies show that the successful outcome of the procedure is related to the applied electric field strength, the total pulse duration as well as the temporal mode of delivery of the pulses. Our best results were obtained using plate electrodes to deliver across the tumor 80 pulses of 100 mu s at 0.3 Hz with an electrical field magnitude of 2500 V/cm. These conditions induced complete regression in 12 out of 13 treated tumors, (92%), in the absence of tissue heating. Irreversible electroporation is thus a new effective modality for non-thermal tumor ablation.","publisher":"PUBLIC LIBRARY SCIENCE","address":"1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA","language":"English","affiliation":"Mir, LM (Corresponding Author), Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France. Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Mir, Lluis M., Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France. Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Mir, Lluis M., Univ Paris Sud, UMR 8121, Villejuif, France. Davalos, Rafael V., Virginia Tech Wake Forest Univ, Sch Biomed Engn & Sci, Blacksburg, VA USA. Rubinsky, Boris, Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA. Rubinsky, Boris, Univ Calif Berkeley, Grad Program Biophys, Berkeley, CA 94720 USA. Rubinsky, Boris, Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA. Rubinsky, Boris, Hebrew Univ Jerusalem, Sch Comp Sci & Engn, Ctr Bioengn Serv Humanity & Soc, Jerusalem, Israel.","doi":"10.1371/journal.pone.0001135","article-number":"e1135","issn":"1932-6203","research-areas":"Science & Technology - Other Topics","web-of-science-categories":"Multidisciplinary Sciences","author-email":"luismir@igr.fr","affiliations":"Centre National de la Recherche Scientifique (CNRS); UNICANCER; Gustave Roussy; Universite Paris Saclay; Virginia Polytechnic Institute & State University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Hebrew University of Jerusalem","researcherid-numbers":"Rubinsky, Boris/B-4439-2010 MIR, Lluis M/AAJ-9110-2020 Davalos, Rafael V/F-9012-2011 Sano, Michael B/E-1715-2011 ","orcid-numbers":", Lluis/0000-0002-8671-9467","funding-acknowledgement":"CNRS; IGR; U. S. National Institutes of Health (NIH) [NIH R01 RR018961]","funding-text":"This work was supported by grants of CNRS and IGR. BR was supported in part by the U. S. National Institutes of Health (NIH) under Grant NIH R01 RR018961. The sponsors had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","number-of-cited-references":"44","times-cited":"358","usage-count-last-180-days":"1","usage-count-since-2013":"33","journal-iso":"PLoS One","doc-delivery-number":"V10IZ","web-of-science-index":"Science Citation Index Expanded (SCI-EXPANDED)","unique-id":"WOS:000207459000019","oa":"gold, Green Published","da":"2024-03-03","bibtex":"@article{ WOS:000207459000019,\nAuthor = {Al-Sakere, Bassim and Andre, Franck and Bernat, Claire and Connault,\n Elisabeth and Opolon, Paule and Davalos, Rafael V. and Rubinsky, Boris\n and Mir, Lluis M.},\nTitle = {Tumor Ablation with Irreversible Electroporation},\nJournal = {PLOS ONE},\nYear = {2007},\nVolume = {2},\nNumber = {11},\nMonth = {NOV 7},\nAbstract = {We report the first successful use of irreversible electroporation for\n the minimally invasive treatment of aggressive cutaneous tumors\n implanted in mice. Irreversible electroporation is a newly developed\n non-thermal tissue ablation technique in which certain short duration\n electrical fields are used to permanently permeabilize the cell\n membrane, presumably through the formation of nanoscale defects in the\n cell membrane. Mathematical models of the electrical and thermal fields\n that develop during the application of the pulses were used to design an\n efficient treatment protocol with minimal heating of the tissue. Tumor\n regression was confirmed by histological studies which also revealed\n that it occurred as a direct result of irreversible cell membrane\n permeabilization. Parametric studies show that the successful outcome of\n the procedure is related to the applied electric field strength, the\n total pulse duration as well as the temporal mode of delivery of the\n pulses. Our best results were obtained using plate electrodes to deliver\n across the tumor 80 pulses of 100 mu s at 0.3 Hz with an electrical\n field magnitude of 2500 V/cm. These conditions induced complete\n regression in 12 out of 13 treated tumors, (92\\%), in the absence of\n tissue heating. Irreversible electroporation is thus a new effective\n modality for non-thermal tumor ablation.},\nPublisher = {PUBLIC LIBRARY SCIENCE},\nAddress = {1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA},\nType = {Article},\nLanguage = {English},\nAffiliation = {Mir, LM (Corresponding Author), Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France.\n Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Mir, Lluis M., Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France.\n Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Mir, Lluis M., Univ Paris Sud, UMR 8121, Villejuif, France.\n Davalos, Rafael V., Virginia Tech Wake Forest Univ, Sch Biomed Engn \\& Sci, Blacksburg, VA USA.\n Rubinsky, Boris, Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA.\n Rubinsky, Boris, Univ Calif Berkeley, Grad Program Biophys, Berkeley, CA 94720 USA.\n Rubinsky, Boris, Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA.\n Rubinsky, Boris, Hebrew Univ Jerusalem, Sch Comp Sci \\& Engn, Ctr Bioengn Serv Humanity \\& Soc, Jerusalem, Israel.},\nDOI = {10.1371/journal.pone.0001135},\nArticle-Number = {e1135},\nISSN = {1932-6203},\nResearch-Areas = {Science \\& Technology - Other Topics},\nWeb-of-Science-Categories = {Multidisciplinary Sciences},\nAuthor-Email = {luismir@igr.fr},\nAffiliations = {Centre National de la Recherche Scientifique (CNRS); UNICANCER; Gustave\n Roussy; Universite Paris Saclay; Virginia Polytechnic Institute \\& State\n University; University of California System; University of California\n Berkeley; University of California System; University of California\n Berkeley; University of California System; University of California\n Berkeley; Hebrew University of Jerusalem},\nResearcherID-Numbers = {Rubinsky, Boris/B-4439-2010\n MIR, Lluis M/AAJ-9110-2020\n Davalos, Rafael V/F-9012-2011\n Sano, Michael B/E-1715-2011\n },\nORCID-Numbers = {, Lluis/0000-0002-8671-9467},\nFunding-Acknowledgement = {CNRS; IGR; U. S. National Institutes of Health (NIH) {[}NIH R01\n RR018961]},\nFunding-Text = {This work was supported by grants of CNRS and IGR. BR was supported in\n part by the U. S. National Institutes of Health (NIH) under Grant NIH\n R01 RR018961. The sponsors had no role in study design, data collection\n and analysis, decision to publish, or preparation of the manuscript.},\nNumber-of-Cited-References = {44},\nTimes-Cited = {358},\nUsage-Count-Last-180-days = {1},\nUsage-Count-Since-2013 = {33},\nJournal-ISO = {PLoS One},\nDoc-Delivery-Number = {V10IZ},\nWeb-of-Science-Index = {Science Citation Index Expanded (SCI-EXPANDED)},\nUnique-ID = {WOS:000207459000019},\nOA = {gold, Green Published},\nDA = {2024-03-03},\n}\n\n","author_short":["Al-Sakere, B.","Andre, F.","Bernat, C.","Connault, E.","Opolon, P.","Davalos, R. V.","Rubinsky, B.","Mir, L. M."],"key":"WOS:000207459000019","id":"WOS:000207459000019","bibbaseid":"alsakere-andre-bernat-connault-opolon-davalos-rubinsky-mir-tumorablationwithirreversibleelectroporation-2007","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/network/files/m6LMYYjquH6L2jgcD","dataSources":["ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW"],"keywords":[],"search_terms":["tumor","ablation","irreversible","electroporation","al-sakere","andre","bernat","connault","opolon","davalos","rubinsky","mir"],"title":"Tumor Ablation with Irreversible Electroporation","year":2007}