Raised Fibrinogen Levels and Outcome in Outpatients With Peripheral Artery Disease. Altes, P., Perez, P., Esteban, C., Sánchez Muñoz-Torrero, J. F., Aguilar, E., García-Díaz, A. M., Álvarez, L. R., Jiménez, P. E., Sahuquillo, J. C., Monreal, M., & FRENA Investigators Angiology, 69(6):507–512, 2018. doi abstract bibtex The influence of raised fibrinogen levels on outcome in stable outpatients with peripheral arterial disease (PAD) has not been consistently investigated. We used data from the Factores de Riesgo y ENfermedad Arterial (FRENA) registry to compare ischemic events, major bleeding, and mortality in stable outpatients with PAD, according to their baseline plasma fibrinogen levels. Of 1363 outpatients with PAD recruited in FRENA, 558 (41%) had fibrinogen levels \textgreater450 mg/100 mL. Over 18 months, 43 patients presented with acute myocardial infarction, 37 had an ischemic stroke, 51 underwent limb amputation, 19 had major bleeding, and 90 died. Compared to patients with normal levels, those with raised fibrinogen levels had an over 2-fold higher rate of ischemic stroke (rate ratio [RR]: 2.30; 95% confidence interval [CI]: 1.19-4.59), limb amputation (RR: 2.58; 95% CI: 1.46-4.67), or death (RR: 2.27; 95% CI: 1.49-3.51) and an over 3-fold higher rate of major bleeding (RR: 3.90; 95% CI: 1.45-12.1). On multivariate analysis, patients with raised fibrinogen levels had an increased risk of developing subsequent ischemic events (hazard ratio [HR]: 1.61; 95% CI: 1.11-2.32) and major bleeding (HR: 3.42; 95% CI: 1.22-9.61). Stable outpatients with PAD and raised plasma fibrinogen levels had increased rates of subsequent ischemic events and major bleeding.
@article{altes_raised_2018,
title = {Raised {Fibrinogen} {Levels} and {Outcome} in {Outpatients} {With} {Peripheral} {Artery} {Disease}},
volume = {69},
issn = {1940-1574},
doi = {10.1177/0003319717739720},
abstract = {The influence of raised fibrinogen levels on outcome in stable outpatients with peripheral arterial disease (PAD) has not been consistently investigated. We used data from the Factores de Riesgo y ENfermedad Arterial (FRENA) registry to compare ischemic events, major bleeding, and mortality in stable outpatients with PAD, according to their baseline plasma fibrinogen levels. Of 1363 outpatients with PAD recruited in FRENA, 558 (41\%) had fibrinogen levels {\textgreater}450 mg/100 mL. Over 18 months, 43 patients presented with acute myocardial infarction, 37 had an ischemic stroke, 51 underwent limb amputation, 19 had major bleeding, and 90 died. Compared to patients with normal levels, those with raised fibrinogen levels had an over 2-fold higher rate of ischemic stroke (rate ratio [RR]: 2.30; 95\% confidence interval [CI]: 1.19-4.59), limb amputation (RR: 2.58; 95\% CI: 1.46-4.67), or death (RR: 2.27; 95\% CI: 1.49-3.51) and an over 3-fold higher rate of major bleeding (RR: 3.90; 95\% CI: 1.45-12.1). On multivariate analysis, patients with raised fibrinogen levels had an increased risk of developing subsequent ischemic events (hazard ratio [HR]: 1.61; 95\% CI: 1.11-2.32) and major bleeding (HR: 3.42; 95\% CI: 1.22-9.61). Stable outpatients with PAD and raised plasma fibrinogen levels had increased rates of subsequent ischemic events and major bleeding.},
language = {eng},
number = {6},
journal = {Angiology},
author = {Altes, Pere and Perez, Paulina and Esteban, Carlos and Sánchez Muñoz-Torrero, Juan Francisco and Aguilar, Eduardo and García-Díaz, Ana María and Álvarez, Lorenzo Ramón and Jiménez, Pedro Enrique and Sahuquillo, Joan Carles and Monreal, Manuel and {FRENA Investigators}},
year = {2018},
pmid = {29113452},
keywords = {Article, Cirurgia Vascular, cardiovascular diseases, fibrinogen, intermittent claudication, outcome, peripheral artery disease},
pages = {507--512},
}
Downloads: 0
{"_id":"ZZrTCcaa3JJpgoQZC","bibbaseid":"altes-perez-esteban-snchezmuoztorrero-aguilar-garcadaz-lvarez-jimnez-etal-raisedfibrinogenlevelsandoutcomeinoutpatientswithperipheralarterydisease-2018","downloads":0,"creationDate":"2018-10-09T14:45:41.542Z","title":"Raised Fibrinogen Levels and Outcome in Outpatients With Peripheral Artery Disease","author_short":["Altes, P.","Perez, P.","Esteban, C.","Sánchez Muñoz-Torrero, J. F.","Aguilar, E.","García-Díaz, A. M.","Álvarez, L. R.","Jiménez, P. E.","Sahuquillo, J. C.","Monreal, M.","FRENA Investigators"],"year":2018,"bibtype":"article","biburl":"https://bibbase.org/zotero/Bibliotecacst","bibdata":{"bibtype":"article","type":"article","title":"Raised Fibrinogen Levels and Outcome in Outpatients With Peripheral Artery Disease","volume":"69","issn":"1940-1574","doi":"10.1177/0003319717739720","abstract":"The influence of raised fibrinogen levels on outcome in stable outpatients with peripheral arterial disease (PAD) has not been consistently investigated. We used data from the Factores de Riesgo y ENfermedad Arterial (FRENA) registry to compare ischemic events, major bleeding, and mortality in stable outpatients with PAD, according to their baseline plasma fibrinogen levels. Of 1363 outpatients with PAD recruited in FRENA, 558 (41%) had fibrinogen levels \\textgreater450 mg/100 mL. Over 18 months, 43 patients presented with acute myocardial infarction, 37 had an ischemic stroke, 51 underwent limb amputation, 19 had major bleeding, and 90 died. Compared to patients with normal levels, those with raised fibrinogen levels had an over 2-fold higher rate of ischemic stroke (rate ratio [RR]: 2.30; 95% confidence interval [CI]: 1.19-4.59), limb amputation (RR: 2.58; 95% CI: 1.46-4.67), or death (RR: 2.27; 95% CI: 1.49-3.51) and an over 3-fold higher rate of major bleeding (RR: 3.90; 95% CI: 1.45-12.1). On multivariate analysis, patients with raised fibrinogen levels had an increased risk of developing subsequent ischemic events (hazard ratio [HR]: 1.61; 95% CI: 1.11-2.32) and major bleeding (HR: 3.42; 95% CI: 1.22-9.61). Stable outpatients with PAD and raised plasma fibrinogen levels had increased rates of subsequent ischemic events and major bleeding.","language":"eng","number":"6","journal":"Angiology","author":[{"propositions":[],"lastnames":["Altes"],"firstnames":["Pere"],"suffixes":[]},{"propositions":[],"lastnames":["Perez"],"firstnames":["Paulina"],"suffixes":[]},{"propositions":[],"lastnames":["Esteban"],"firstnames":["Carlos"],"suffixes":[]},{"propositions":[],"lastnames":["Sánchez","Muñoz-Torrero"],"firstnames":["Juan","Francisco"],"suffixes":[]},{"propositions":[],"lastnames":["Aguilar"],"firstnames":["Eduardo"],"suffixes":[]},{"propositions":[],"lastnames":["García-Díaz"],"firstnames":["Ana","María"],"suffixes":[]},{"propositions":[],"lastnames":["Álvarez"],"firstnames":["Lorenzo","Ramón"],"suffixes":[]},{"propositions":[],"lastnames":["Jiménez"],"firstnames":["Pedro","Enrique"],"suffixes":[]},{"propositions":[],"lastnames":["Sahuquillo"],"firstnames":["Joan","Carles"],"suffixes":[]},{"propositions":[],"lastnames":["Monreal"],"firstnames":["Manuel"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["FRENA Investigators"],"suffixes":[]}],"year":"2018","pmid":"29113452","keywords":"Article, Cirurgia Vascular, cardiovascular diseases, fibrinogen, intermittent claudication, outcome, peripheral artery disease","pages":"507–512","bibtex":"@article{altes_raised_2018,\n\ttitle = {Raised {Fibrinogen} {Levels} and {Outcome} in {Outpatients} {With} {Peripheral} {Artery} {Disease}},\n\tvolume = {69},\n\tissn = {1940-1574},\n\tdoi = {10.1177/0003319717739720},\n\tabstract = {The influence of raised fibrinogen levels on outcome in stable outpatients with peripheral arterial disease (PAD) has not been consistently investigated. We used data from the Factores de Riesgo y ENfermedad Arterial (FRENA) registry to compare ischemic events, major bleeding, and mortality in stable outpatients with PAD, according to their baseline plasma fibrinogen levels. Of 1363 outpatients with PAD recruited in FRENA, 558 (41\\%) had fibrinogen levels {\\textgreater}450 mg/100 mL. Over 18 months, 43 patients presented with acute myocardial infarction, 37 had an ischemic stroke, 51 underwent limb amputation, 19 had major bleeding, and 90 died. Compared to patients with normal levels, those with raised fibrinogen levels had an over 2-fold higher rate of ischemic stroke (rate ratio [RR]: 2.30; 95\\% confidence interval [CI]: 1.19-4.59), limb amputation (RR: 2.58; 95\\% CI: 1.46-4.67), or death (RR: 2.27; 95\\% CI: 1.49-3.51) and an over 3-fold higher rate of major bleeding (RR: 3.90; 95\\% CI: 1.45-12.1). On multivariate analysis, patients with raised fibrinogen levels had an increased risk of developing subsequent ischemic events (hazard ratio [HR]: 1.61; 95\\% CI: 1.11-2.32) and major bleeding (HR: 3.42; 95\\% CI: 1.22-9.61). Stable outpatients with PAD and raised plasma fibrinogen levels had increased rates of subsequent ischemic events and major bleeding.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Angiology},\n\tauthor = {Altes, Pere and Perez, Paulina and Esteban, Carlos and Sánchez Muñoz-Torrero, Juan Francisco and Aguilar, Eduardo and García-Díaz, Ana María and Álvarez, Lorenzo Ramón and Jiménez, Pedro Enrique and Sahuquillo, Joan Carles and Monreal, Manuel and {FRENA Investigators}},\n\tyear = {2018},\n\tpmid = {29113452},\n\tkeywords = {Article, Cirurgia Vascular, cardiovascular diseases, fibrinogen, intermittent claudication, outcome, peripheral artery disease},\n\tpages = {507--512},\n}\n\n","author_short":["Altes, P.","Perez, P.","Esteban, C.","Sánchez Muñoz-Torrero, J. F.","Aguilar, E.","García-Díaz, A. M.","Álvarez, L. R.","Jiménez, P. E.","Sahuquillo, J. C.","Monreal, M.","FRENA Investigators"],"key":"altes_raised_2018","id":"altes_raised_2018","bibbaseid":"altes-perez-esteban-snchezmuoztorrero-aguilar-garcadaz-lvarez-jimnez-etal-raisedfibrinogenlevelsandoutcomeinoutpatientswithperipheralarterydisease-2018","role":"author","urls":{},"keyword":["Article","Cirurgia Vascular","cardiovascular diseases","fibrinogen","intermittent claudication","outcome","peripheral artery disease"],"downloads":0,"html":"","metadata":{"authorlinks":{}}},"search_terms":["raised","fibrinogen","levels","outcome","outpatients","peripheral","artery","disease","altes","perez","esteban","sánchez muñoz-torrero","aguilar","garcía-díaz","álvarez","jiménez","sahuquillo","monreal","frena investigators"],"keywords":["article","cirurgia vascular","cardiovascular diseases","fibrinogen","intermittent claudication","outcome","peripheral artery disease"],"authorIDs":[],"dataSources":["TR9pX4mH5rDPr29Zo"]}