@article{altintop_synthesis_2014,
	title = {Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents},
	volume = {74},
	issn = {1768-3254},
	doi = {10.1016/j.ejmech.2013.12.060},
	abstract = {N'-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3 cells. Compound 22 bearing 1-phenyl-1H-tetrazole and p-chlorophenyl moieties was found to be the most promising antibacterial agent against Pseudomonas aeruginosa, whereas compound 23 bearing 1-phenyl-1H-tetrazole and p-bromophenyl moieties was the most promising antifungal agent against Candida albicans. The most effective derivatives were also evaluated for their cytotoxicity against C6 glioma cells. The results indicated that compound 17 bearing 1-phenyl-1H-tetrazole and nonsubstituted phenyl moieties (IC₅₀ = 8.3 ± 2.6 μg/mL) was more effective than cisplatin (IC₅₀ = 13.7 ± 1.2 μg/mL) against C6 glioma cells. Compound 17 also exhibited DNA synthesis inhibitory activity on C6 cells. Furthermore, compound 17 showed low toxicity to NIH/3T3 cells (IC₅₀ = 416.7 ± 28.9 μg/mL).},
	language = {eng},
	journal = {European Journal of Medicinal Chemistry},
	author = {Altıntop, Mehlika Dilek and Kaplancıklı, Zafer Asım and Ciftçi, Gülşen Akalın and Demirel, Rasime},
	month = mar,
	year = {2014},
	pmid = {24480358},
	keywords = {Animals, Anti-Infective Agents, Antimicrobial activity, Antineoplastic Agents, Candida albicans, Cell Line, Tumor, Cytotoxicity, DNA synthesis inhibitory activity, Drug Evaluation, Preclinical, Humans, Hydrazone, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Microbial Sensitivity Tests, NIH 3T3 Cells, Pseudomonas aeruginosa, Spectroscopy, Fourier Transform Infrared, Thiazoles, Thiazoline},
	pages = {264--277},
}

{"_id":"jhaaqqaWncjTYXxEB","bibbaseid":"altntop-kaplanckl-cifti-demirel-synthesisandbiologicalevaluationofthiazolinederivativesasnewantimicrobialandanticanceragents-2014","author_short":["Altıntop, M. D.","Kaplancıklı, Z. A.","Ciftçi, G. A.","Demirel, R."],"bibdata":{"bibtype":"article","type":"article","title":"Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents","volume":"74","issn":"1768-3254","doi":"10.1016/j.ejmech.2013.12.060","abstract":"N'-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3 cells. Compound 22 bearing 1-phenyl-1H-tetrazole and p-chlorophenyl moieties was found to be the most promising antibacterial agent against Pseudomonas aeruginosa, whereas compound 23 bearing 1-phenyl-1H-tetrazole and p-bromophenyl moieties was the most promising antifungal agent against Candida albicans. The most effective derivatives were also evaluated for their cytotoxicity against C6 glioma cells. The results indicated that compound 17 bearing 1-phenyl-1H-tetrazole and nonsubstituted phenyl moieties (IC₅₀ = 8.3 ± 2.6 μg/mL) was more effective than cisplatin (IC₅₀ = 13.7 ± 1.2 μg/mL) against C6 glioma cells. Compound 17 also exhibited DNA synthesis inhibitory activity on C6 cells. Furthermore, compound 17 showed low toxicity to NIH/3T3 cells (IC₅₀ = 416.7 ± 28.9 μg/mL).","language":"eng","journal":"European Journal of Medicinal Chemistry","author":[{"propositions":[],"lastnames":["Altıntop"],"firstnames":["Mehlika","Dilek"],"suffixes":[]},{"propositions":[],"lastnames":["Kaplancıklı"],"firstnames":["Zafer","Asım"],"suffixes":[]},{"propositions":[],"lastnames":["Ciftçi"],"firstnames":["Gülşen","Akalın"],"suffixes":[]},{"propositions":[],"lastnames":["Demirel"],"firstnames":["Rasime"],"suffixes":[]}],"month":"March","year":"2014","pmid":"24480358","keywords":"Animals, Anti-Infective Agents, Antimicrobial activity, Antineoplastic Agents, Candida albicans, Cell Line, Tumor, Cytotoxicity, DNA synthesis inhibitory activity, Drug Evaluation, Preclinical, Humans, Hydrazone, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Microbial Sensitivity Tests, NIH 3T3 Cells, Pseudomonas aeruginosa, Spectroscopy, Fourier Transform Infrared, Thiazoles, Thiazoline","pages":"264–277","bibtex":"@article{altintop_synthesis_2014,\n\ttitle = {Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents},\n\tvolume = {74},\n\tissn = {1768-3254},\n\tdoi = {10.1016/j.ejmech.2013.12.060},\n\tabstract = {N'-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3 cells. Compound 22 bearing 1-phenyl-1H-tetrazole and p-chlorophenyl moieties was found to be the most promising antibacterial agent against Pseudomonas aeruginosa, whereas compound 23 bearing 1-phenyl-1H-tetrazole and p-bromophenyl moieties was the most promising antifungal agent against Candida albicans. The most effective derivatives were also evaluated for their cytotoxicity against C6 glioma cells. The results indicated that compound 17 bearing 1-phenyl-1H-tetrazole and nonsubstituted phenyl moieties (IC₅₀ = 8.3 ± 2.6 μg/mL) was more effective than cisplatin (IC₅₀ = 13.7 ± 1.2 μg/mL) against C6 glioma cells. Compound 17 also exhibited DNA synthesis inhibitory activity on C6 cells. Furthermore, compound 17 showed low toxicity to NIH/3T3 cells (IC₅₀ = 416.7 ± 28.9 μg/mL).},\n\tlanguage = {eng},\n\tjournal = {European Journal of Medicinal Chemistry},\n\tauthor = {Altıntop, Mehlika Dilek and Kaplancıklı, Zafer Asım and Ciftçi, Gülşen Akalın and Demirel, Rasime},\n\tmonth = mar,\n\tyear = {2014},\n\tpmid = {24480358},\n\tkeywords = {Animals, Anti-Infective Agents, Antimicrobial activity, Antineoplastic Agents, Candida albicans, Cell Line, Tumor, Cytotoxicity, DNA synthesis inhibitory activity, Drug Evaluation, Preclinical, Humans, Hydrazone, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Microbial Sensitivity Tests, NIH 3T3 Cells, Pseudomonas aeruginosa, Spectroscopy, Fourier Transform Infrared, Thiazoles, Thiazoline},\n\tpages = {264--277},\n}\n\n","author_short":["Altıntop, M. D.","Kaplancıklı, Z. A.","Ciftçi, G. A.","Demirel, R."],"key":"altintop_synthesis_2014","id":"altintop_synthesis_2014","bibbaseid":"altntop-kaplanckl-cifti-demirel-synthesisandbiologicalevaluationofthiazolinederivativesasnewantimicrobialandanticanceragents-2014","role":"author","urls":{},"keyword":["Animals","Anti-Infective Agents","Antimicrobial activity","Antineoplastic Agents","Candida albicans","Cell Line","Tumor","Cytotoxicity","DNA synthesis inhibitory activity","Drug Evaluation","Preclinical","Humans","Hydrazone","Magnetic Resonance Spectroscopy","Mass Spectrometry","Mice","Microbial Sensitivity Tests","NIH 3T3 Cells","Pseudomonas aeruginosa","Spectroscopy","Fourier Transform Infrared","Thiazoles","Thiazoline"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/tplas","dataSources":["YLgywGcXWx96vKKaB"],"keywords":["animals","anti-infective agents","antimicrobial activity","antineoplastic agents","candida albicans","cell line","tumor","cytotoxicity","dna synthesis inhibitory activity","drug evaluation","preclinical","humans","hydrazone","magnetic resonance spectroscopy","mass spectrometry","mice","microbial sensitivity tests","nih 3t3 cells","pseudomonas aeruginosa","spectroscopy","fourier transform infrared","thiazoles","thiazoline"],"search_terms":["synthesis","biological","evaluation","thiazoline","derivatives","new","antimicrobial","anticancer","agents","altıntop","kaplancıklı","ciftçi","demirel"],"title":"Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents","year":2014}