Vibroacoustic disease- Biological effects of infrasound and low-frequency noise explained by mechanotransduction cellular signalling. Alves-Pereira, M. & Branco, N. A. C. Progress in Biophysics and Molecular Biology, 93:256-279, 2007. abstract bibtex At present, infrasound (0–20 Hz) and low-frequency noise (20–500 Hz) (ILFN, 0–500 Hz) are agents of disease that go unchecked. Vibroacoustic disease (VAD) is a whole-body pathology that develops in individuals excessively exposed to ILFN. VAD has been diagnosed within several professional groups employed within the aeronautical industry, and in other heavy industries. However, given the ubiquitous nature of ILFN and the absence of legislation concerning ILFN, VAD is increasingly being diagnosed among members of the general population, including children. VAD is associated with the abnormal growth of extra-cellular matrices (collagen and elastin), in the absence of an inflammatory process. In VAD, the end-product of collagen and elastin growth is reinforcement of structural integrity. This is seen in blood vessels, cardiac structures, trachea, lung, and kidney of both VAD patients and ILFN-exposed animals. VAD is, essentially, a mechanotransduction disease. Inter- and intra-cellular communication is achieved through both biochemical and mechanotranduction signalling. When the structural components of tissue are altered, as is seen in ILFN-exposed specimens, the mechanically mediated signalling is, at best, impaired. Common medical diagnostic tests, such as EKG, EEG, as well as many blood chemistry analyses, are based on the mal-function of biochemical signalling processes. VAD patients typically present normal values for these tests. However, when echocardiography, brain MRI or histological studies are performed, where structural changes can be identified, all consistently show significant changes in VAD patients and ILFN-exposed animals. Frequency-specific effects are not yet known, valid dose-responses have been difficult to identify, and large-scale epidemiological studies are still lacking.
@article{Alves-Pereira2007a,
abstract = {At present, infrasound (0–20 Hz) and low-frequency noise (20–500 Hz)
(ILFN, 0–500 Hz) are agents of disease that go unchecked. Vibroacoustic
disease (VAD) is a whole-body pathology that develops in individuals
excessively exposed to ILFN. VAD has been diagnosed within several
professional groups employed within the aeronautical industry, and
in other heavy industries. However, given the ubiquitous nature of
ILFN and the absence of legislation concerning ILFN, VAD is increasingly
being diagnosed among members of the general population, including
children. VAD is associated with the abnormal growth of extra-cellular
matrices (collagen and elastin), in the absence of an inflammatory
process. In VAD, the end-product of collagen and elastin growth is
reinforcement of structural integrity. This is seen in blood vessels,
cardiac structures, trachea, lung, and kidney of both VAD patients
and ILFN-exposed animals. VAD is, essentially, a mechanotransduction
disease. Inter- and intra-cellular communication is achieved through
both biochemical and mechanotranduction signalling. When the structural
components of tissue are altered, as is seen in ILFN-exposed specimens,
the mechanically mediated signalling is, at best, impaired. Common
medical diagnostic tests, such as EKG, EEG, as well as many blood
chemistry analyses, are based on the mal-function of biochemical
signalling processes. VAD patients typically present normal values
for these tests. However, when echocardiography, brain MRI or histological
studies are performed, where structural changes can be identified,
all consistently show significant changes in VAD patients and ILFN-exposed
animals. Frequency-specific effects are not yet known, valid dose-responses
have been difficult to identify, and large-scale epidemiological
studies are still lacking.},
added-at = {2012-01-27T14:10:42.000+0100},
author = {Alves-Pereira, Mariana and Branco, Nuno A.A. Castelo},
biburl = {https://www.bibsonomy.org/bibtex/2cb92a45919ab185a17cacafe7f392635/muhe},
file = {Vibroacoustic disease- Biological effects of infrasound and low-frequency noise explained by mechanotransduction cellular signalling.pdf:2007\\Vibroacoustic disease- Biological effects of infrasound and low-frequency noise explained by mechanotransduction cellular signalling.pdf:PDF},
interhash = {bbeb864ba7880fefe5e2bd7d488c1ed0},
intrahash = {cb92a45919ab185a17cacafe7f392635},
journal = {Progress in Biophysics and Molecular Biology},
keywords = {Collagen; Tensegrity Extra-cellular Actin; Tubulin; matrix;},
owner = {Mu},
pages = {256-279},
timestamp = {2012-01-27T14:10:43.000+0100},
title = {Vibroacoustic disease- Biological effects of infrasound and low-frequency
noise explained by mechanotransduction cellular signalling},
volume = 93,
year = 2007
}
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In VAD, the end-product of collagen and elastin growth is reinforcement of structural integrity. This is seen in blood vessels, cardiac structures, trachea, lung, and kidney of both VAD patients and ILFN-exposed animals. VAD is, essentially, a mechanotransduction disease. Inter- and intra-cellular communication is achieved through both biochemical and mechanotranduction signalling. When the structural components of tissue are altered, as is seen in ILFN-exposed specimens, the mechanically mediated signalling is, at best, impaired. Common medical diagnostic tests, such as EKG, EEG, as well as many blood chemistry analyses, are based on the mal-function of biochemical signalling processes. VAD patients typically present normal values for these tests. However, when echocardiography, brain MRI or histological studies are performed, where structural changes can be identified, all consistently show significant changes in VAD patients and ILFN-exposed animals. 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Vibroacoustic\n\tdisease (VAD) is a whole-body pathology that develops in individuals\n\texcessively exposed to ILFN. VAD has been diagnosed within several\n\tprofessional groups employed within the aeronautical industry, and\n\tin other heavy industries. However, given the ubiquitous nature of\n\tILFN and the absence of legislation concerning ILFN, VAD is increasingly\n\tbeing diagnosed among members of the general population, including\n\tchildren. VAD is associated with the abnormal growth of extra-cellular\n\tmatrices (collagen and elastin), in the absence of an inflammatory\n\tprocess. In VAD, the end-product of collagen and elastin growth is\n\treinforcement of structural integrity. This is seen in blood vessels,\n\tcardiac structures, trachea, lung, and kidney of both VAD patients\n\tand ILFN-exposed animals. VAD is, essentially, a mechanotransduction\n\tdisease. Inter- and intra-cellular communication is achieved through\n\tboth biochemical and mechanotranduction signalling. 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