@article{RN6077,
   author = {Amin, S. B. and Anderson, K. J. and Boudreau, C. E. and Martinez-Ledesma, E. and Kocakavuk, E. and Johnson, K. C. and Barthel, F. P. and Varn, F. S. and Kassab, C. and Ling, X. and Kim, H. and Barter, M. and Lau, C. C. and Ngan, C. Y. and Chapman, M. and Koehler, J. W. and Long, J. P. and Miller, A. D. and Miller, C. R. and Porter, B. F. and Rissi, D. R. and Mazcko, C. and LeBlanc, A. K. and Dickinson, P. J. and Packer, R. A. and Taylor, A. R. and Rossmeisl, J. H., Jr. and Woolard, K. D. and Heimberger, A. B. and Levine, J. M. and Verhaak, R. G. W.},
   title = {Comparative Molecular Life History of Spontaneous Canine and Human Gliomas},
   journal = {Cancer Cell},
   volume = {37},
   number = {2},
   pages = {243-257.e7},
   note = {1878-3686
Amin, Samirkumar B
Anderson, Kevin J
Boudreau, C Elizabeth
Martinez-Ledesma, Emmanuel
Kocakavuk, Emre
Johnson, Kevin C
Barthel, Floris P
Varn, Frederick S
Kassab, Cynthia
Ling, Xiaoyang
Kim, Hoon
Barter, Mary
Lau, Ching C
Ngan, Chew Yee
Chapman, Margaret
Koehler, Jennifer W
Long, James P
Miller, Andrew D
Miller, C Ryan
Porter, Brian F
Rissi, Daniel R
Mazcko, Christina
LeBlanc, Amy K
Dickinson, Peter J
Packer, Rebecca A
Taylor, Amanda R
Rossmeisl, John H Jr
Woolard, Kevin D
Heimberger, Amy B
Levine, Jonathan M
Verhaak, Roel G W
R01 CA120813/CA/NCI NIH HHS/United States
P30 CA016672/CA/NCI NIH HHS/United States
R01 CA190121/CA/NCI NIH HHS/United States
P30 CA034196/CA/NCI NIH HHS/United States
K99 CA226387/CA/NCI NIH HHS/United States
Z01 BC006161/ImNIH/Intramural NIH HHS/United States
P01 CA207206/CA/NCI NIH HHS/United States
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
United States
2020/02/13
Cancer Cell. 2020 Feb 10;37(2):243-257.e7. doi: 10.1016/j.ccell.2020.01.004.},
   abstract = {Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.},
   keywords = {Animals
Brain Neoplasms/*genetics
DNA Methylation/*genetics
Dogs
Exome/genetics
Glioma/*genetics
Humans
Isocitrate Dehydrogenase/genetics
Mutation/*genetics
Tumor Suppressor Protein p53/genetics
adult glioma
canine glioma
comparative genomics
comparative oncology
computational biology
life history
mutagenesis
pediatric glioma},
   ISSN = {1535-6108 (Print)
1535-6108},
   DOI = {10.1016/j.ccell.2020.01.004},
   year = {2020},
   type = {Journal Article}
}

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W."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Amin"],"firstnames":["S.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Anderson"],"firstnames":["K.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Boudreau"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Martinez-Ledesma"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Kocakavuk"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Johnson"],"firstnames":["K.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Barthel"],"firstnames":["F.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Varn"],"firstnames":["F.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Kassab"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Ling"],"firstnames":["X."],"suffixes":[]},{"propositions":[],"lastnames":["Kim"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Barter"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Lau"],"firstnames":["C.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Ngan"],"firstnames":["C.","Y."],"suffixes":[]},{"propositions":[],"lastnames":["Chapman"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Koehler"],"firstnames":["J.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Long"],"firstnames":["J.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Miller"],"firstnames":["A.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Miller"],"firstnames":["C.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Porter"],"firstnames":["B.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Rissi"],"firstnames":["D.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Mazcko"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["LeBlanc"],"firstnames":["A.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Dickinson"],"firstnames":["P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Packer"],"firstnames":["R.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Taylor"],"firstnames":["A.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Rossmeisl"],"firstnames":["J.","H."],"suffixes":["Jr."]},{"propositions":[],"lastnames":["Woolard"],"firstnames":["K.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Heimberger"],"firstnames":["A.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Levine"],"firstnames":["J.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Verhaak"],"firstnames":["R.","G.","W."],"suffixes":[]}],"title":"Comparative Molecular Life History of Spontaneous Canine and Human Gliomas","journal":"Cancer Cell","volume":"37","number":"2","pages":"243-257.e7","note":"1878-3686 Amin, Samirkumar B Anderson, Kevin J Boudreau, C Elizabeth Martinez-Ledesma, Emmanuel Kocakavuk, Emre Johnson, Kevin C Barthel, Floris P Varn, Frederick S Kassab, Cynthia Ling, Xiaoyang Kim, Hoon Barter, Mary Lau, Ching C Ngan, Chew Yee Chapman, Margaret Koehler, Jennifer W Long, James P Miller, Andrew D Miller, C Ryan Porter, Brian F Rissi, Daniel R Mazcko, Christina LeBlanc, Amy K Dickinson, Peter J Packer, Rebecca A Taylor, Amanda R Rossmeisl, John H Jr Woolard, Kevin D Heimberger, Amy B Levine, Jonathan M Verhaak, Roel G W R01 CA120813/CA/NCI NIH HHS/United States P30 CA016672/CA/NCI NIH HHS/United States R01 CA190121/CA/NCI NIH HHS/United States P30 CA034196/CA/NCI NIH HHS/United States K99 CA226387/CA/NCI NIH HHS/United States Z01 BC006161/ImNIH/Intramural NIH HHS/United States P01 CA207206/CA/NCI NIH HHS/United States Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't United States 2020/02/13 Cancer Cell. 2020 Feb 10;37(2):243-257.e7. doi: 10.1016/j.ccell.2020.01.004.","abstract":"Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.","keywords":"Animals Brain Neoplasms/*genetics DNA Methylation/*genetics Dogs Exome/genetics Glioma/*genetics Humans Isocitrate Dehydrogenase/genetics Mutation/*genetics Tumor Suppressor Protein p53/genetics adult glioma canine glioma comparative genomics comparative oncology computational biology life history mutagenesis pediatric glioma","issn":"1535-6108 (Print) 1535-6108","doi":"10.1016/j.ccell.2020.01.004","year":"2020","bibtex":"@article{RN6077,\n author = {Amin, S. B. and Anderson, K. J. and Boudreau, C. E. and Martinez-Ledesma, E. and Kocakavuk, E. and Johnson, K. C. and Barthel, F. P. and Varn, F. S. and Kassab, C. and Ling, X. and Kim, H. and Barter, M. and Lau, C. C. and Ngan, C. Y. and Chapman, M. and Koehler, J. W. and Long, J. P. and Miller, A. D. and Miller, C. R. and Porter, B. F. and Rissi, D. R. and Mazcko, C. and LeBlanc, A. K. and Dickinson, P. J. and Packer, R. A. and Taylor, A. R. and Rossmeisl, J. H., Jr. and Woolard, K. D. and Heimberger, A. B. and Levine, J. M. and Verhaak, R. G. W.},\n title = {Comparative Molecular Life History of Spontaneous Canine and Human Gliomas},\n journal = {Cancer Cell},\n volume = {37},\n number = {2},\n pages = {243-257.e7},\n note = {1878-3686\nAmin, Samirkumar B\nAnderson, Kevin J\nBoudreau, C Elizabeth\nMartinez-Ledesma, Emmanuel\nKocakavuk, Emre\nJohnson, Kevin C\nBarthel, Floris P\nVarn, Frederick S\nKassab, Cynthia\nLing, Xiaoyang\nKim, Hoon\nBarter, Mary\nLau, Ching C\nNgan, Chew Yee\nChapman, Margaret\nKoehler, Jennifer W\nLong, James P\nMiller, Andrew D\nMiller, C Ryan\nPorter, Brian F\nRissi, Daniel R\nMazcko, Christina\nLeBlanc, Amy K\nDickinson, Peter J\nPacker, Rebecca A\nTaylor, Amanda R\nRossmeisl, John H Jr\nWoolard, Kevin D\nHeimberger, Amy B\nLevine, Jonathan M\nVerhaak, Roel G W\nR01 CA120813/CA/NCI NIH HHS/United States\nP30 CA016672/CA/NCI NIH HHS/United States\nR01 CA190121/CA/NCI NIH HHS/United States\nP30 CA034196/CA/NCI NIH HHS/United States\nK99 CA226387/CA/NCI NIH HHS/United States\nZ01 BC006161/ImNIH/Intramural NIH HHS/United States\nP01 CA207206/CA/NCI NIH HHS/United States\nComparative Study\nJournal Article\nResearch Support, N.I.H., Extramural\nResearch Support, N.I.H., Intramural\nResearch Support, Non-U.S. Gov't\nUnited States\n2020/02/13\nCancer Cell. 2020 Feb 10;37(2):243-257.e7. doi: 10.1016/j.ccell.2020.01.004.},\n abstract = {Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.},\n keywords = {Animals\nBrain Neoplasms/*genetics\nDNA Methylation/*genetics\nDogs\nExome/genetics\nGlioma/*genetics\nHumans\nIsocitrate Dehydrogenase/genetics\nMutation/*genetics\nTumor Suppressor Protein p53/genetics\nadult glioma\ncanine glioma\ncomparative genomics\ncomparative oncology\ncomputational biology\nlife history\nmutagenesis\npediatric glioma},\n ISSN = {1535-6108 (Print)\n1535-6108},\n DOI = {10.1016/j.ccell.2020.01.004},\n year = {2020},\n type = {Journal Article}\n}\n\n","author_short":["Amin, S. B.","Anderson, K. J.","Boudreau, C. E.","Martinez-Ledesma, E.","Kocakavuk, E.","Johnson, K. C.","Barthel, F. P.","Varn, F. S.","Kassab, C.","Ling, X.","Kim, H.","Barter, M.","Lau, C. C.","Ngan, C. Y.","Chapman, M.","Koehler, J. W.","Long, J. P.","Miller, A. D.","Miller, C. R.","Porter, B. F.","Rissi, D. 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