@article{
 title = {Proton therapy for spinal ependymomas: planning, acute toxicities, and preliminary outcomes.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adolescent,Child,Child, Preschool,Disease-Free Survival,Ependymoma,Ependymoma: pathology,Ependymoma: radiotherapy,Ependymoma: surgery,Erythema,Erythema: etiology,Erythema: pathology,Fatigue,Fatigue: etiology,Female,Follow-Up Studies,Humans,Infant,Male,Neoplasm Recurrence, Local,Neoplasm Recurrence, Local: radiotherapy,Protons,Protons: adverse effects,Protons: therapeutic use,Radiation Injuries,Radiotherapy Dosage,Spinal Neoplasms,Spinal Neoplasms: pathology,Spinal Neoplasms: radiotherapy,Spinal Neoplasms: surgery,Survival Rate,Treatment Outcome,Tumor Burden},
 pages = {1419-24},
 volume = {83},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22245209},
 month = {8},
 publisher = {Elsevier Inc},
 day = {1},
 id = {ba888ca5-70c7-39d5-946d-244183b6d8d3},
 created = {2014-03-15T18:24:10.000Z},
 accessed = {2014-03-04},
 file_attached = {true},
 profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T19:36:51.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
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 abstract = {PURPOSE: To report acute toxicities and preliminary outcomes for pediatric patients with ependymomas of the spine treated with proton beam therapy at the MD Anderson Cancer Center.

METHODS AND MATERIALS: Eight pediatric patients received proton beam irradiation between October 2006 and September 2010 for spinal ependymomas. Toxicity data were collected weekly during radiation therapy and all follow-up visits. Toxicities were graded according to the Common Terminology Criteria for Adverse Events version 3.0.

RESULTS: All patients had surgical resection of the tumor before irradiation (7 subtotal resection and 1 gross total resection). Six patients had World Health Organization Grade I ependymomas, and two had World Health Organization Grade II ependymomas. Patients had up to 3 surgical interventions before radiation therapy (range, 1-3; median, 1). Three patients received proton therapy after recurrence and five as part of their primary management. The entire vertebral body was treated in all but 2 patients. The mean radiation dose was 51.1 cobalt gray equivalents (range, 45 to 54 cobalt gray equivalents). With a mean follow-up of 26 months from the radiation therapy start date (range, 7-51 months), local control, event-free survival, and overall survival rates were all 100%. The most common toxicities during treatment were Grade 1 or 2 erythema (75%) and Grade 1 fatigue (38%). No patients had a Grade 3 or higher adverse event. Proton therapy dramatically reduced dose to all normal tissues anterior to the vertebral bodies in comparison to photon therapy.

CONCLUSION: Preliminary outcomes show the expected control rates with favorable acute toxicity profiles. Proton beam therapy offers a powerful treatment option in the pediatric population, where adverse events related to radiation exposure are of concern. Extended follow-up will be required to assess for late recurrences and long-term adverse effects.},
 bibtype = {article},
 author = {Amsbaugh, Mark J and Grosshans, David R and McAleer, Mary Frances and Zhu, Ron and Wages, Cody and Crawford, Cody N and Palmer, Matthew and De Gracia, Beth and Woo, Shiao and Mahajan, Anita},
 journal = {International Journal of Radiation Oncology Biology Physics},
 number = {5}
}

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Toxicity data were collected weekly during radiation therapy and all follow-up visits. Toxicities were graded according to the Common Terminology Criteria for Adverse Events version 3.0.\n\nRESULTS: All patients had surgical resection of the tumor before irradiation (7 subtotal resection and 1 gross total resection). Six patients had World Health Organization Grade I ependymomas, and two had World Health Organization Grade II ependymomas. Patients had up to 3 surgical interventions before radiation therapy (range, 1-3; median, 1). Three patients received proton therapy after recurrence and five as part of their primary management. The entire vertebral body was treated in all but 2 patients. The mean radiation dose was 51.1 cobalt gray equivalents (range, 45 to 54 cobalt gray equivalents). With a mean follow-up of 26 months from the radiation therapy start date (range, 7-51 months), local control, event-free survival, and overall survival rates were all 100%. The most common toxicities during treatment were Grade 1 or 2 erythema (75%) and Grade 1 fatigue (38%). No patients had a Grade 3 or higher adverse event. Proton therapy dramatically reduced dose to all normal tissues anterior to the vertebral bodies in comparison to photon therapy.\n\nCONCLUSION: Preliminary outcomes show the expected control rates with favorable acute toxicity profiles. Proton beam therapy offers a powerful treatment option in the pediatric population, where adverse events related to radiation exposure are of concern. Extended follow-up will be required to assess for late recurrences and long-term adverse effects.","bibtype":"article","author":"Amsbaugh, Mark J and Grosshans, David R and McAleer, Mary Frances and Zhu, Ron and Wages, Cody and Crawford, Cody N and Palmer, Matthew and De Gracia, Beth and Woo, Shiao and Mahajan, Anita","journal":"International Journal of Radiation Oncology Biology Physics","number":"5","bibtex":"@article{\n title = {Proton therapy for spinal ependymomas: planning, acute toxicities, and preliminary outcomes.},\n type = {article},\n year = {2012},\n identifiers = {[object Object]},\n keywords = {Adolescent,Child,Child, Preschool,Disease-Free Survival,Ependymoma,Ependymoma: pathology,Ependymoma: radiotherapy,Ependymoma: surgery,Erythema,Erythema: etiology,Erythema: pathology,Fatigue,Fatigue: etiology,Female,Follow-Up Studies,Humans,Infant,Male,Neoplasm Recurrence, Local,Neoplasm Recurrence, Local: radiotherapy,Protons,Protons: adverse effects,Protons: therapeutic use,Radiation Injuries,Radiotherapy Dosage,Spinal Neoplasms,Spinal Neoplasms: pathology,Spinal Neoplasms: radiotherapy,Spinal Neoplasms: surgery,Survival Rate,Treatment Outcome,Tumor Burden},\n pages = {1419-24},\n volume = {83},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/22245209},\n month = {8},\n publisher = {Elsevier Inc},\n day = {1},\n id = {ba888ca5-70c7-39d5-946d-244183b6d8d3},\n created = {2014-03-15T18:24:10.000Z},\n accessed = {2014-03-04},\n file_attached = {true},\n profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},\n group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},\n last_modified = {2014-12-29T19:36:51.000Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n abstract = {PURPOSE: To report acute toxicities and preliminary outcomes for pediatric patients with ependymomas of the spine treated with proton beam therapy at the MD Anderson Cancer Center.\n\nMETHODS AND MATERIALS: Eight pediatric patients received proton beam irradiation between October 2006 and September 2010 for spinal ependymomas. Toxicity data were collected weekly during radiation therapy and all follow-up visits. Toxicities were graded according to the Common Terminology Criteria for Adverse Events version 3.0.\n\nRESULTS: All patients had surgical resection of the tumor before irradiation (7 subtotal resection and 1 gross total resection). Six patients had World Health Organization Grade I ependymomas, and two had World Health Organization Grade II ependymomas. Patients had up to 3 surgical interventions before radiation therapy (range, 1-3; median, 1). Three patients received proton therapy after recurrence and five as part of their primary management. The entire vertebral body was treated in all but 2 patients. The mean radiation dose was 51.1 cobalt gray equivalents (range, 45 to 54 cobalt gray equivalents). With a mean follow-up of 26 months from the radiation therapy start date (range, 7-51 months), local control, event-free survival, and overall survival rates were all 100%. The most common toxicities during treatment were Grade 1 or 2 erythema (75%) and Grade 1 fatigue (38%). No patients had a Grade 3 or higher adverse event. Proton therapy dramatically reduced dose to all normal tissues anterior to the vertebral bodies in comparison to photon therapy.\n\nCONCLUSION: Preliminary outcomes show the expected control rates with favorable acute toxicity profiles. Proton beam therapy offers a powerful treatment option in the pediatric population, where adverse events related to radiation exposure are of concern. Extended follow-up will be required to assess for late recurrences and long-term adverse effects.},\n bibtype = {article},\n author = {Amsbaugh, Mark J and Grosshans, David R and McAleer, Mary Frances and Zhu, Ron and Wages, Cody and Crawford, Cody N and Palmer, Matthew and De Gracia, Beth and Woo, Shiao and Mahajan, Anita},\n journal = {International Journal of Radiation Oncology Biology Physics},\n number = {5}\n}","author_short":["Amsbaugh, M., J.","Grosshans, D., R.","McAleer, M., F.","Zhu, R.","Wages, C.","Crawford, C., N.","Palmer, M.","De Gracia, B.","Woo, S.","Mahajan, A."],"urls":{"Paper":"http://bibbase.org/service/mendeley/8c4ca2d5-86de-3b5d-86be-8408415f34e0/file/3b54b17d-79a8-c0a1-5de2-1d4b065abc7a/2012-Proton_therapy_for_spinal_ependymomas_planning_acute_toxicities_and_preliminary_outcomes..pdf.pdf"},"bibbaseid":"amsbaugh-grosshans-mcaleer-zhu-wages-crawford-palmer-degracia-woo-mahajan-protontherapyforspinalependymomasplanningacutetoxicitiesandpreliminaryoutcomes-2012","role":"author","keyword":["Adolescent","Child","Child","Preschool","Disease-Free Survival","Ependymoma","Ependymoma: pathology","Ependymoma: radiotherapy","Ependymoma: surgery","Erythema","Erythema: etiology","Erythema: pathology","Fatigue","Fatigue: etiology","Female","Follow-Up Studies","Humans","Infant","Male","Neoplasm Recurrence","Local","Neoplasm Recurrence","Local: radiotherapy","Protons","Protons: adverse effects","Protons: therapeutic use","Radiation Injuries","Radiotherapy Dosage","Spinal Neoplasms","Spinal Neoplasms: pathology","Spinal Neoplasms: radiotherapy","Spinal Neoplasms: surgery","Survival Rate","Treatment Outcome","Tumor Burden"],"downloads":0},"search_terms":["proton","therapy","spinal","ependymomas","planning","acute","toxicities","preliminary","outcomes","amsbaugh","grosshans","mcaleer","zhu","wages","crawford","palmer","de gracia","woo","mahajan"],"keywords":["adolescent","child","child","preschool","disease-free survival","ependymoma","ependymoma: pathology","ependymoma: radiotherapy","ependymoma: surgery","erythema","erythema: etiology","erythema: pathology","fatigue","fatigue: etiology","female","follow-up studies","humans","infant","male","neoplasm recurrence","local","neoplasm recurrence","local: radiotherapy","protons","protons: adverse effects","protons: therapeutic use","radiation injuries","radiotherapy dosage","spinal neoplasms","spinal neoplasms: pathology","spinal neoplasms: radiotherapy","spinal neoplasms: surgery","survival rate","treatment outcome","tumor burden"],"authorIDs":[]}