Requirement of B2-Type Cyclin-Dependent Kinases for Meristem Integrity in Arabidopsis thaliana

Requirement of B2-Type Cyclin-Dependent Kinases for Meristem Integrity in Arabidopsis thaliana. Andersen, S. U., Buechel, S., Zhao, Z., Ljung, K., Novák, O., Busch, W., Schuster, C., & Lohmann, J. U. The Plant Cell, 20(1):88–100, February, 2008.

Paper doi abstract bibtex

Abstract To maintain proper meristem function, cell division and differentiation must be coordinately regulated in distinct subdomains of the meristem. Although a number of regulators necessary for the correct organization of the shoot apical meristem (SAM) have been identified, it is still largely unknown how their function is integrated with the cell cycle machinery to translate domain identity into correct cellular behavior. We show here that the cyclin-dependent kinases CDKB2;1 and CDKB2;2 are required both for normal cell cycle progression and for meristem organization. Consistently, the CDKB2 genes are highly expressed in the SAM in a cell cycle–dependent fashion, and disruption of CDKB2 function leads to severe meristematic defects. In addition, strong alterations in hormone signaling both at the level of active hormones and with respect to transcriptional and physiological outputs were observed in plants with disturbed CDKB2 activity.

@article{andersen_requirement_2008,
	title = {Requirement of {B2}-{Type} \textit{{Cyclin}-{Dependent} {Kinases}} for {Meristem} {Integrity} in \textit{{Arabidopsis} thaliana}},
	volume = {20},
	issn = {1532-298X},
	url = {https://academic.oup.com/plcell/article/20/1/88/6091364},
	doi = {10/djf5gv},
	abstract = {Abstract
            To maintain proper meristem function, cell division and differentiation must be coordinately regulated in distinct subdomains of the meristem. Although a number of regulators necessary for the correct organization of the shoot apical meristem (SAM) have been identified, it is still largely unknown how their function is integrated with the cell cycle machinery to translate domain identity into correct cellular behavior. We show here that the cyclin-dependent kinases CDKB2;1 and CDKB2;2 are required both for normal cell cycle progression and for meristem organization. Consistently, the CDKB2 genes are highly expressed in the SAM in a cell cycle–dependent fashion, and disruption of CDKB2 function leads to severe meristematic defects. In addition, strong alterations in hormone signaling both at the level of active hormones and with respect to transcriptional and physiological outputs were observed in plants with disturbed CDKB2 activity.},
	language = {en},
	number = {1},
	urldate = {2021-06-10},
	journal = {The Plant Cell},
	author = {Andersen, Stig Uggerhøj and Buechel, Sabine and Zhao, Zhong and Ljung, Karin and Novák, Ondřej and Busch, Wolfgang and Schuster, Christoph and Lohmann, Jan U.},
	month = feb,
	year = {2008},
	pages = {88--100},
}

Downloads: 0

{"_id":"PLEEkFGqtM3boKYAF","bibbaseid":"andersen-buechel-zhao-ljung-novk-busch-schuster-lohmann-requirementofb2typeicyclindependentkinasesiformeristemintegrityiniarabidopsisthalianai-2008","author_short":["Andersen, S. U.","Buechel, S.","Zhao, Z.","Ljung, K.","Novák, O.","Busch, W.","Schuster, C.","Lohmann, J. U."],"bibdata":{"bibtype":"article","type":"article","title":"Requirement of B2-Type Cyclin-Dependent Kinases for Meristem Integrity in Arabidopsis thaliana","volume":"20","issn":"1532-298X","url":"https://academic.oup.com/plcell/article/20/1/88/6091364","doi":"10/djf5gv","abstract":"Abstract To maintain proper meristem function, cell division and differentiation must be coordinately regulated in distinct subdomains of the meristem. Although a number of regulators necessary for the correct organization of the shoot apical meristem (SAM) have been identified, it is still largely unknown how their function is integrated with the cell cycle machinery to translate domain identity into correct cellular behavior. We show here that the cyclin-dependent kinases CDKB2;1 and CDKB2;2 are required both for normal cell cycle progression and for meristem organization. Consistently, the CDKB2 genes are highly expressed in the SAM in a cell cycle–dependent fashion, and disruption of CDKB2 function leads to severe meristematic defects. In addition, strong alterations in hormone signaling both at the level of active hormones and with respect to transcriptional and physiological outputs were observed in plants with disturbed CDKB2 activity.","language":"en","number":"1","urldate":"2021-06-10","journal":"The Plant Cell","author":[{"propositions":[],"lastnames":["Andersen"],"firstnames":["Stig","Uggerhøj"],"suffixes":[]},{"propositions":[],"lastnames":["Buechel"],"firstnames":["Sabine"],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["Zhong"],"suffixes":[]},{"propositions":[],"lastnames":["Ljung"],"firstnames":["Karin"],"suffixes":[]},{"propositions":[],"lastnames":["Novák"],"firstnames":["Ondřej"],"suffixes":[]},{"propositions":[],"lastnames":["Busch"],"firstnames":["Wolfgang"],"suffixes":[]},{"propositions":[],"lastnames":["Schuster"],"firstnames":["Christoph"],"suffixes":[]},{"propositions":[],"lastnames":["Lohmann"],"firstnames":["Jan","U."],"suffixes":[]}],"month":"February","year":"2008","pages":"88–100","bibtex":"@article{andersen_requirement_2008,\n\ttitle = {Requirement of {B2}-{Type} \\textit{{Cyclin}-{Dependent} {Kinases}} for {Meristem} {Integrity} in \\textit{{Arabidopsis} thaliana}},\n\tvolume = {20},\n\tissn = {1532-298X},\n\turl = {https://academic.oup.com/plcell/article/20/1/88/6091364},\n\tdoi = {10/djf5gv},\n\tabstract = {Abstract\n To maintain proper meristem function, cell division and differentiation must be coordinately regulated in distinct subdomains of the meristem. Although a number of regulators necessary for the correct organization of the shoot apical meristem (SAM) have been identified, it is still largely unknown how their function is integrated with the cell cycle machinery to translate domain identity into correct cellular behavior. We show here that the cyclin-dependent kinases CDKB2;1 and CDKB2;2 are required both for normal cell cycle progression and for meristem organization. Consistently, the CDKB2 genes are highly expressed in the SAM in a cell cycle–dependent fashion, and disruption of CDKB2 function leads to severe meristematic defects. In addition, strong alterations in hormone signaling both at the level of active hormones and with respect to transcriptional and physiological outputs were observed in plants with disturbed CDKB2 activity.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-06-10},\n\tjournal = {The Plant Cell},\n\tauthor = {Andersen, Stig Uggerhøj and Buechel, Sabine and Zhao, Zhong and Ljung, Karin and Novák, Ondřej and Busch, Wolfgang and Schuster, Christoph and Lohmann, Jan U.},\n\tmonth = feb,\n\tyear = {2008},\n\tpages = {88--100},\n}\n\n\n\n","author_short":["Andersen, S. U.","Buechel, S.","Zhao, Z.","Ljung, K.","Novák, O.","Busch, W.","Schuster, C.","Lohmann, J. U."],"key":"andersen_requirement_2008","id":"andersen_requirement_2008","bibbaseid":"andersen-buechel-zhao-ljung-novk-busch-schuster-lohmann-requirementofb2typeicyclindependentkinasesiformeristemintegrityiniarabidopsisthalianai-2008","role":"author","urls":{"Paper":"https://academic.oup.com/plcell/article/20/1/88/6091364"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/upscpub","dataSources":["fvfkWcShg3Mybjoog","Tu3jPdZyJF3j547xT","9cGcv2t8pRzC92kzs","3zTPPmKj8BiTcpc6C"],"keywords":[],"search_terms":["requirement","type","cyclin","dependent","kinases","meristem","integrity","arabidopsis","thaliana","andersen","buechel","zhao","ljung","novák","busch","schuster","lohmann"],"title":"Requirement of B2-Type Cyclin-Dependent Kinases for Meristem Integrity in Arabidopsis thaliana","year":2008}