Atmospheric pressure chemical ionization source. 1. Ionization of compounds in the gas phase. Andrade, F., J., Shelley, J., T., Wetzel, W., C., Webb, M., R., Gamez, G., Ray, S., J., & Hieftje, G., M. Analytical chemistry, 80(8):2646-53, 4, 2008. ![Atmospheric pressure chemical ionization source. 1. Ionization of compounds in the gas phase. [pdf]](https://bibbase.org/img/filetypes/pdf.svg "pdf")
Paper ![Atmospheric pressure chemical ionization source. 1. Ionization of compounds in the gas phase. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex A novel chemical ionization source for organic mass spectrometry is introduced. This new source uses a glow discharge in the flowing afterglow mode for the generation of excited species and ions. The direct-current gas discharge is operated in helium at atmospheric pressure; typical operating voltages and currents are around 500 V and 25 mA, respectively. The species generated by this atmospheric pressure glow discharge are mixed with ambient air to generate reagent ions (mostly ionized water clusters and NO+), which are then used for the ionization of gaseous organic compounds. A wide variety of substances, both polar and nonpolar, can be ionized. The resulting mass spectra generally show the parent molecular ion (M+ or MH+) with little or no fragmentation. Proton transfer from ionized water clusters has been identified as the main ionization pathway. However, the presence of radical molecular ions (M+) for some compounds indicates that other ionization mechanisms are also involved. The analytical capabilities of this source were evaluated with a time-of-flight mass spectrometer, and preliminary characterization shows very good stability, linearity, and sensitivity. Limits of detection in the single to tens of femtomole range are reported for selected compounds.
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title = {Atmospheric pressure chemical ionization source. 1. Ionization of compounds in the gas phase.},
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abstract = {A novel chemical ionization source for organic mass spectrometry is introduced. This new source uses a glow discharge in the flowing afterglow mode for the generation of excited species and ions. The direct-current gas discharge is operated in helium at atmospheric pressure; typical operating voltages and currents are around 500 V and 25 mA, respectively. The species generated by this atmospheric pressure glow discharge are mixed with ambient air to generate reagent ions (mostly ionized water clusters and NO+), which are then used for the ionization of gaseous organic compounds. A wide variety of substances, both polar and nonpolar, can be ionized. The resulting mass spectra generally show the parent molecular ion (M+ or MH+) with little or no fragmentation. Proton transfer from ionized water clusters has been identified as the main ionization pathway. However, the presence of radical molecular ions (M+) for some compounds indicates that other ionization mechanisms are also involved. The analytical capabilities of this source were evaluated with a time-of-flight mass spectrometer, and preliminary characterization shows very good stability, linearity, and sensitivity. Limits of detection in the single to tens of femtomole range are reported for selected compounds.},
bibtype = {article},
author = {Andrade, Francisco J and Shelley, Jacob T and Wetzel, William C and Webb, Michael R and Gamez, Gerardo and Ray, Steven J and Hieftje, Gary M},
journal = {Analytical chemistry},
number = {8}
}
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