Ischaemic preconditioning of the graft in adult living related right lobe liver transplantation: impact on ischaemia-reperfusion injury and clinical relevance. Andreani, P., Hoti, E., de la Serna, S., degli Esposti, D., Sebagh, M., Lemoine, A., Ichai, P., Saliba, F., Castaing, D., & Azoulay, D. HPB (Oxford), 12(7):439–46, 2010. ![Ischaemic preconditioning of the graft in adult living related right lobe liver transplantation: impact on ischaemia-reperfusion injury and clinical relevance [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BACKGROUND: Ischaemic preconditioning (IPC) of the right liver graft in the donor has not been studied in adult-to-adult living related liver transplantation (LRLT). OBJECTIVE: To assess the IPC effect of the graft on ischaemia reperfusion injury in the recipient and compare recipient and donor outcomes with and without preconditioned grafts. PATIENTS AND METHODS: Alternate patients were transplanted with right lobe grafts that were (n = 22; Group (Precond)) or were not (n = 22; Group (Control)) subjected to IPC in the living donor. Liver ischaemia-reperfusion injury, liver/kidney function, morbidity/mortality rates and outcomes were compared. Univariate and multivariate analyses were performed to identify factors predictive of the aspartate aminotransferase (AST) peak and minimum prothrombin time. RESULTS: Both groups had similar length of hospital stay, morbidity/mortality, primary non-function and acute rejection rates. Post-operative AST (P = 0.8) and alanine aminotransferase (ALT) peaks (P = 0.6) were similar in both groups (307 +/- 189 and 437 +/- 302 vs. 290 +/- 146 and 496 +/- 343, respectively). In univariate analysis, only pre-operative AST and warm ischemia time (WIT) were significantly associated with post-operative AST peak (in recipients). In multivariate analysis, the graft/recipient weight ratio (P = 0.003) and pre-operative bilirubin concentration (P = 0.004) were significantly predictive of minimum prothrombin time post-transplantation. CONCLUSIONS: Graft IPC in the living related donor is not associated with any benefit for the recipient or the donor and its clinical value remains uncertain.
@article{andreani_ischaemic_2010,
title = {Ischaemic preconditioning of the graft in adult living related right lobe liver transplantation: impact on ischaemia-reperfusion injury and clinical relevance},
volume = {12},
issn = {1477-2574 (ELECTRONIC) 1365-182X (LINKING)},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20815852},
doi = {HPB194 [pii] 10.1111/j.1477-2574.2010.00194.x},
abstract = {BACKGROUND: Ischaemic preconditioning (IPC) of the right liver graft in the donor has not been studied in adult-to-adult living related liver transplantation (LRLT). OBJECTIVE: To assess the IPC effect of the graft on ischaemia reperfusion injury in the recipient and compare recipient and donor outcomes with and without preconditioned grafts. PATIENTS AND METHODS: Alternate patients were transplanted with right lobe grafts that were (n = 22; Group (Precond)) or were not (n = 22; Group (Control)) subjected to IPC in the living donor. Liver ischaemia-reperfusion injury, liver/kidney function, morbidity/mortality rates and outcomes were compared. Univariate and multivariate analyses were performed to identify factors predictive of the aspartate aminotransferase (AST) peak and minimum prothrombin time. RESULTS: Both groups had similar length of hospital stay, morbidity/mortality, primary non-function and acute rejection rates. Post-operative AST (P = 0.8) and alanine aminotransferase (ALT) peaks (P = 0.6) were similar in both groups (307 +/- 189 and 437 +/- 302 vs. 290 +/- 146 and 496 +/- 343, respectively). In univariate analysis, only pre-operative AST and warm ischemia time (WIT) were significantly associated with post-operative AST peak (in recipients). In multivariate analysis, the graft/recipient weight ratio (P = 0.003) and pre-operative bilirubin concentration (P = 0.004) were significantly predictive of minimum prothrombin time post-transplantation. CONCLUSIONS: Graft IPC in the living related donor is not associated with any benefit for the recipient or the donor and its clinical value remains uncertain.},
number = {7},
journal = {HPB (Oxford)},
author = {Andreani, P. and Hoti, E. and de la Serna, S. and degli Esposti, D. and Sebagh, M. and Lemoine, A. and Ichai, P. and Saliba, F. and Castaing, D. and Azoulay, D.},
year = {2010},
keywords = {\&, *Ischemic, *Liver, *Living, *Warm, Adult, Aged, Aminotransferases/blood, Aspartate, Assessment, Biological, Biopsy, Blood, Coagulation, Donors, Estimate, Factors, Female, France, Humans, Injury/blood/etiology/mortality/*prevention, Ischemia/adverse, Kaplan-Meier, Length, Male, Markers/blood, Middle, Outcome, Preconditioning/adverse, Prospective, Prothrombin, Rate, Reperfusion, Risk, Stay, Studies, Survival, Time, Transplantation/adverse, Treatment, control, effects, effects/mortality, of},
pages = {439--46},
}
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OBJECTIVE: To assess the IPC effect of the graft on ischaemia reperfusion injury in the recipient and compare recipient and donor outcomes with and without preconditioned grafts. PATIENTS AND METHODS: Alternate patients were transplanted with right lobe grafts that were (n = 22; Group (Precond)) or were not (n = 22; Group (Control)) subjected to IPC in the living donor. Liver ischaemia-reperfusion injury, liver/kidney function, morbidity/mortality rates and outcomes were compared. Univariate and multivariate analyses were performed to identify factors predictive of the aspartate aminotransferase (AST) peak and minimum prothrombin time. RESULTS: Both groups had similar length of hospital stay, morbidity/mortality, primary non-function and acute rejection rates. Post-operative AST (P = 0.8) and alanine aminotransferase (ALT) peaks (P = 0.6) were similar in both groups (307 +/- 189 and 437 +/- 302 vs. 290 +/- 146 and 496 +/- 343, respectively). In univariate analysis, only pre-operative AST and warm ischemia time (WIT) were significantly associated with post-operative AST peak (in recipients). In multivariate analysis, the graft/recipient weight ratio (P = 0.003) and pre-operative bilirubin concentration (P = 0.004) were significantly predictive of minimum prothrombin time post-transplantation. CONCLUSIONS: Graft IPC in the living related donor is not associated with any benefit for the recipient or the donor and its clinical value remains uncertain.","number":"7","journal":"HPB (Oxford)","author":[{"propositions":[],"lastnames":["Andreani"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Hoti"],"firstnames":["E."],"suffixes":[]},{"propositions":["de","la"],"lastnames":["Serna"],"firstnames":["S."],"suffixes":[]},{"propositions":["degli"],"lastnames":["Esposti"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Sebagh"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Lemoine"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Ichai"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Saliba"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["Castaing"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Azoulay"],"firstnames":["D."],"suffixes":[]}],"year":"2010","keywords":"&, *Ischemic, *Liver, *Living, *Warm, Adult, Aged, Aminotransferases/blood, Aspartate, Assessment, Biological, Biopsy, Blood, Coagulation, Donors, Estimate, Factors, Female, France, Humans, Injury/blood/etiology/mortality/*prevention, Ischemia/adverse, Kaplan-Meier, Length, Male, Markers/blood, Middle, Outcome, Preconditioning/adverse, Prospective, Prothrombin, Rate, Reperfusion, Risk, Stay, Studies, Survival, Time, Transplantation/adverse, Treatment, control, effects, effects/mortality, of","pages":"439–46","bibtex":"@article{andreani_ischaemic_2010,\n\ttitle = {Ischaemic preconditioning of the graft in adult living related right lobe liver transplantation: impact on ischaemia-reperfusion injury and clinical relevance},\n\tvolume = {12},\n\tissn = {1477-2574 (ELECTRONIC) 1365-182X (LINKING)},\n\turl = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20815852},\n\tdoi = {HPB194 [pii] 10.1111/j.1477-2574.2010.00194.x},\n\tabstract = {BACKGROUND: Ischaemic preconditioning (IPC) of the right liver graft in the donor has not been studied in adult-to-adult living related liver transplantation (LRLT). OBJECTIVE: To assess the IPC effect of the graft on ischaemia reperfusion injury in the recipient and compare recipient and donor outcomes with and without preconditioned grafts. PATIENTS AND METHODS: Alternate patients were transplanted with right lobe grafts that were (n = 22; Group (Precond)) or were not (n = 22; Group (Control)) subjected to IPC in the living donor. Liver ischaemia-reperfusion injury, liver/kidney function, morbidity/mortality rates and outcomes were compared. Univariate and multivariate analyses were performed to identify factors predictive of the aspartate aminotransferase (AST) peak and minimum prothrombin time. RESULTS: Both groups had similar length of hospital stay, morbidity/mortality, primary non-function and acute rejection rates. Post-operative AST (P = 0.8) and alanine aminotransferase (ALT) peaks (P = 0.6) were similar in both groups (307 +/- 189 and 437 +/- 302 vs. 290 +/- 146 and 496 +/- 343, respectively). In univariate analysis, only pre-operative AST and warm ischemia time (WIT) were significantly associated with post-operative AST peak (in recipients). In multivariate analysis, the graft/recipient weight ratio (P = 0.003) and pre-operative bilirubin concentration (P = 0.004) were significantly predictive of minimum prothrombin time post-transplantation. CONCLUSIONS: Graft IPC in the living related donor is not associated with any benefit for the recipient or the donor and its clinical value remains uncertain.},\n\tnumber = {7},\n\tjournal = {HPB (Oxford)},\n\tauthor = {Andreani, P. and Hoti, E. and de la Serna, S. and degli Esposti, D. and Sebagh, M. and Lemoine, A. and Ichai, P. and Saliba, F. and Castaing, D. and Azoulay, D.},\n\tyear = {2010},\n\tkeywords = {\\&, *Ischemic, *Liver, *Living, *Warm, Adult, Aged, Aminotransferases/blood, Aspartate, Assessment, Biological, Biopsy, Blood, Coagulation, Donors, Estimate, Factors, Female, France, Humans, Injury/blood/etiology/mortality/*prevention, Ischemia/adverse, Kaplan-Meier, Length, Male, Markers/blood, Middle, Outcome, Preconditioning/adverse, Prospective, Prothrombin, Rate, Reperfusion, Risk, Stay, Studies, Survival, Time, Transplantation/adverse, Treatment, control, effects, effects/mortality, of},\n\tpages = {439--46},\n}\n\n\n\n","author_short":["Andreani, P.","Hoti, E.","de la Serna, S.","degli Esposti, D.","Sebagh, M.","Lemoine, A.","Ichai, P.","Saliba, F.","Castaing, D.","Azoulay, D."],"key":"andreani_ischaemic_2010","id":"andreani_ischaemic_2010","bibbaseid":"andreani-hoti-delaserna-degliesposti-sebagh-lemoine-ichai-saliba-etal-ischaemicpreconditioningofthegraftinadultlivingrelatedrightlobelivertransplantationimpactonischaemiareperfusioninjuryandclinicalrelevance-2010","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20815852"},"keyword":["&","*Ischemic","*Liver","*Living","*Warm","Adult","Aged","Aminotransferases/blood","Aspartate","Assessment","Biological","Biopsy","Blood","Coagulation","Donors","Estimate","Factors","Female","France","Humans","Injury/blood/etiology/mortality/*prevention","Ischemia/adverse","Kaplan-Meier","Length","Male","Markers/blood","Middle","Outcome","Preconditioning/adverse","Prospective","Prothrombin","Rate","Reperfusion","Risk","Stay","Studies","Survival","Time","Transplantation/adverse","Treatment","control","effects","effects/mortality","of"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://bibbase.org/zotero/biblioial","dataSources":["ftoP3zPyb2N3b9Noc"],"keywords":["&","*ischemic","*liver","*living","*warm","adult","aged","aminotransferases/blood","aspartate","assessment","biological","biopsy","blood","coagulation","donors","estimate","factors","female","france","humans","injury/blood/etiology/mortality/*prevention","ischemia/adverse","kaplan-meier","length","male","markers/blood","middle","outcome","preconditioning/adverse","prospective","prothrombin","rate","reperfusion","risk","stay","studies","survival","time","transplantation/adverse","treatment","control","effects","effects/mortality","of"],"search_terms":["ischaemic","preconditioning","graft","adult","living","related","right","lobe","liver","transplantation","impact","ischaemia","reperfusion","injury","clinical","relevance","andreani","hoti","de la serna","degli esposti","sebagh","lemoine","ichai","saliba","castaing","azoulay"],"title":"Ischaemic preconditioning of the graft in adult living related right lobe liver transplantation: impact on ischaemia-reperfusion injury and clinical relevance","year":2010}