@ARTICLE{Andrews2022-ht,
  title    = "Challenges of Organoid Research",
  author   = "Andrews, Madeline G and Kriegstein, Arnold R",
  abstract = "Organoids are 3D cell culture systems derived from human
              pluripotent stem cells that contain tissue resident cell types
              and reflect features of early tissue organization. Neural
              organoids are a particularly innovative scientific advance given
              the lack of accessibility of developing human brain tissue and
              intractability of neurological diseases. Neural organoids have
              become an invaluable approach to model features of human brain
              development that are not well reflected in animal models.
              Organoids also hold promise for the study of atypical cellular,
              molecular, and genetic features that underscore neurological
              diseases. Additionally, organoids may provide a platform for
              testing therapeutics in human cells and are a potential source
              for cell replacement approaches to brain injury or disease.
              Despite the promising features of organoids, their broad utility
              is tempered by a variety of limitations yet to be overcome,
              including lack of high-fidelity cell types, limited maturation,
              atypical physiology, and lack of arealization, features that may
              limit their reliability for certain applications.",
  journal  = "Annu Rev Neurosci",
  volume   =  45,
  pages    = "23--39",
  month    =  jan,
  year     =  2022,
  address  = "United States",
  keywords = "human development; modeling human disease; neural development;
              neuroscience; organoids; stem cell models",
  language = "en"
}

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