An approximate internal model principle: Applications to nonlinear models of biological systems. Andrews, B., Sontag, E., & Iglesias, P. In Proc. 17th IFAC World Congress, Seoul, pages Paper FrB25.3, 6 pages, 2008. abstract bibtex The proper function of many biological systems requires that external perturbations be detected, allowing the system to adapt to these environmental changes. It is now well established that this dual detection and adaptation requires that the system have an internal model in the feedback loop. In this paper we relax the requirement that the response of the system adapt perfectly, but instead allow regulation to within a neighborhood of zero. We show, in a nonlinear setting, that systems with the ability to detect input signals and approximately adapt require an approximate model of the input. We illustrate our results by analyzing a well-studied biological system. These results generalize previous work which treats the perfectly adapting case.
@INPROCEEDINGS{iglesias_ifac08,
AUTHOR = {B. Andrews and E.D. Sontag and P. Iglesias},
BOOKTITLE = {Proc. 17th IFAC World Congress, Seoul},
TITLE = {An approximate internal model principle: Applications to
nonlinear models of biological systems},
YEAR = {2008},
OPTADDRESS = {},
OPTCROSSREF = {},
OPTEDITOR = {},
OPTMONTH = {},
OPTNOTE = {},
OPTNUMBER = {},
OPTORGANIZATION = {},
PAGES = {Paper FrB25.3, 6 pages},
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KEYWORDS = {biological adaptation, internal model principle},
PDF = {../../FTPDIR/andrews_sontag_iglesias_approximate_internal_model_IFAC2008.pdf},
ABSTRACT = {The proper function of many biological systems requires
that external perturbations be detected, allowing the system to adapt
to these environmental changes. It is now well established that this
dual detection and adaptation requires that the system have an
internal model in the feedback loop. In this paper we relax the
requirement that the response of the system adapt perfectly, but
instead allow regulation to within a neighborhood of zero. We show,
in a nonlinear setting, that systems with the ability to detect input
signals and approximately adapt require an approximate model of the
input. We illustrate our results by analyzing a well-studied
biological system. These results generalize previous work which
treats the perfectly adapting case. }
}
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