@ARTICLE{Andrews2020-nm,
  title    = "{mTOR} signaling regulates the morphology and migration of outer
              radial glia in developing human cortex",
  author   = "Andrews, Madeline G and Subramanian, Lakshmi and Kriegstein,
              Arnold R",
  abstract = "Outer radial glial (oRG) cells are a population of neural stem
              cells prevalent in the developing human cortex that contribute to
              its cellular diversity and evolutionary expansion. The mammalian
              Target of Rapamycin (mTOR) signaling pathway is active in human
              oRG cells. Mutations in mTOR pathway genes are linked to a
              variety of neurodevelopmental disorders and malformations of
              cortical development. We find that dysregulation of mTOR
              signaling specifically affects oRG cells, but not other
              progenitor types, by changing the actin cytoskeleton through the
              activity of the Rho-GTPase, CDC42. These effects change oRG
              cellular morphology, migration, and mitotic behavior, but do not
              affect proliferation or cell fate. Thus, mTOR signaling can
              regulate the architecture of the developing human cortex by
              maintaining the cytoskeletal organization of oRG cells and the
              radial glia scaffold. Our study provides insight into how mTOR
              dysregulation may contribute to neurodevelopmental disease.",
  journal  = "Elife",
  volume   =  9,
  month    =  sep,
  year     =  2020,
  keywords = "human; human cortex; neuroscience; organoids; outer radial glia;
              regenerative medicine; stem cells",
  language = "en"
}

{"_id":"A5HCwc4bCeCAoF4kB","bibbaseid":"andrews-subramanian-kriegstein-mtorsignalingregulatesthemorphologyandmigrationofouterradialgliaindevelopinghumancortex-2020","author_short":["Andrews, M. G","Subramanian, L.","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex","author":[{"propositions":[],"lastnames":["Andrews"],"firstnames":["Madeline","G"],"suffixes":[]},{"propositions":[],"lastnames":["Subramanian"],"firstnames":["Lakshmi"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its cellular diversity and evolutionary expansion. The mammalian Target of Rapamycin (mTOR) signaling pathway is active in human oRG cells. Mutations in mTOR pathway genes are linked to a variety of neurodevelopmental disorders and malformations of cortical development. We find that dysregulation of mTOR signaling specifically affects oRG cells, but not other progenitor types, by changing the actin cytoskeleton through the activity of the Rho-GTPase, CDC42. These effects change oRG cellular morphology, migration, and mitotic behavior, but do not affect proliferation or cell fate. Thus, mTOR signaling can regulate the architecture of the developing human cortex by maintaining the cytoskeletal organization of oRG cells and the radial glia scaffold. Our study provides insight into how mTOR dysregulation may contribute to neurodevelopmental disease.","journal":"Elife","volume":"9","month":"September","year":"2020","keywords":"human; human cortex; neuroscience; organoids; outer radial glia; regenerative medicine; stem cells","language":"en","bibtex":"@ARTICLE{Andrews2020-nm,\n title = \"{mTOR} signaling regulates the morphology and migration of outer\n radial glia in developing human cortex\",\n author = \"Andrews, Madeline G and Subramanian, Lakshmi and Kriegstein,\n Arnold R\",\n abstract = \"Outer radial glial (oRG) cells are a population of neural stem\n cells prevalent in the developing human cortex that contribute to\n its cellular diversity and evolutionary expansion. The mammalian\n Target of Rapamycin (mTOR) signaling pathway is active in human\n oRG cells. Mutations in mTOR pathway genes are linked to a\n variety of neurodevelopmental disorders and malformations of\n cortical development. We find that dysregulation of mTOR\n signaling specifically affects oRG cells, but not other\n progenitor types, by changing the actin cytoskeleton through the\n activity of the Rho-GTPase, CDC42. These effects change oRG\n cellular morphology, migration, and mitotic behavior, but do not\n affect proliferation or cell fate. Thus, mTOR signaling can\n regulate the architecture of the developing human cortex by\n maintaining the cytoskeletal organization of oRG cells and the\n radial glia scaffold. Our study provides insight into how mTOR\n dysregulation may contribute to neurodevelopmental disease.\",\n journal = \"Elife\",\n volume = 9,\n month = sep,\n year = 2020,\n keywords = \"human; human cortex; neuroscience; organoids; outer radial glia;\n regenerative medicine; stem cells\",\n language = \"en\"\n}\n\n","author_short":["Andrews, M. G","Subramanian, L.","Kriegstein, A. R"],"key":"Andrews2020-nm","id":"Andrews2020-nm","bibbaseid":"andrews-subramanian-kriegstein-mtorsignalingregulatesthemorphologyandmigrationofouterradialgliaindevelopinghumancortex-2020","role":"author","urls":{},"keyword":["human; human cortex; neuroscience; organoids; outer radial glia; regenerative medicine; stem cells"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":["human; human cortex; neuroscience; organoids; outer radial glia; regenerative medicine; stem cells"],"search_terms":["mtor","signaling","regulates","morphology","migration","outer","radial","glia","developing","human","cortex","andrews","subramanian","kriegstein"],"title":"mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex","year":2020}