@ARTICLE{Andrews2022-uu,
  title    = "How mechanisms of stem cell polarity shape the human cerebral
              cortex",
  author   = "Andrews, Madeline G and Subramanian, Lakshmi and Salma, Jahan and
              Kriegstein, Arnold R",
  abstract = "Apical-basal progenitor cell polarity establishes key features of
              the radial and laminar architecture of the developing human
              cortex. The unique diversity of cortical stem cell populations
              and an expansion of progenitor population size in the human
              cortex have been mirrored by an increase in the complexity of
              cellular processes that regulate stem cell morphology and
              behaviour, including their polarity. The study of human cells in
              primary tissue samples and human stem cell-derived model systems
              (such as cortical organoids) has provided insight into these
              processes, revealing that protein complexes regulate progenitor
              polarity by controlling cell membrane adherence within
              appropriate cortical niches and are themselves regulated by
              cytoskeletal proteins, signalling molecules and receptors, and
              cellular organelles. Studies exploring how cortical stem cell
              polarity is established and maintained are key for understanding
              the features of human brain development and have implications for
              neurological dysfunction.",
  journal  = "Nat Rev Neurosci",
  month    =  sep,
  year     =  2022,
  address  = "England",
  language = "en"
}

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