Atlas of gene expression in the developing kidney at microanatomic resolution. Developmental cell, 15(5):781--791, November, 2008. ![Atlas of gene expression in the developing kidney at microanatomic resolution. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Kidney development is based on differential cell-type-specific expression of a vast number of genes. While multiple critical genes and pathways have been elucidated, a genome-wide analysis of gene expression within individual cellular and anatomic structures is lacking. Accomplishing this could provide significant new insights into fundamental developmental mechanisms such as mesenchymal-epithelial transition, inductive signaling, branching morphogenesis, and segmentation. We describe here a comprehensive gene expression atlas of the developing mouse kidney based on the isolation of each major compartment by either laser capture microdissection or fluorescence-activated cell sorting, followed by microarray profiling. The resulting data agree with known expression patterns and additional in situ hybridizations. This kidney atlas allows a comprehensive analysis of the progression of gene expression states during nephrogenesis, as well as discovery of potential growth factor-receptor interactions. In addition, the results provide deeper insight into the genetic regulatory mechanisms of kidney development.
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{"_id":"CdZZDcryYZ3RLhfDr","bibbaseid":"anonymous-atlasofgeneexpressioninthedevelopingkidneyatmicroanatomicresolution-2008","downloads":0,"creationDate":"2017-12-11T17:23:55.110Z","title":"Atlas of gene expression in the developing kidney at microanatomic resolution.","author_short":null,"year":2008,"bibtype":"article","biburl":"http://valeriuslab.org/valeriuspub2017bib","bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Brunskill"],"firstnames":["Eric","W"],"suffixes":[]},{"propositions":[],"lastnames":["Aronow"],"firstnames":["Bruce","J"],"suffixes":[]},{"propositions":[],"lastnames":["Georgas"],"firstnames":["Kylie"],"suffixes":[]},{"propositions":[],"lastnames":["Rumballe"],"firstnames":["Bree"],"suffixes":[]},{"propositions":[],"lastnames":["Valerius"],"firstnames":["M","Todd"],"suffixes":[]},{"propositions":[],"lastnames":["Aronow"],"firstnames":["Jeremy"],"suffixes":[]},{"propositions":[],"lastnames":["Kaimal"],"firstnames":["Vivek"],"suffixes":[]},{"propositions":[],"lastnames":["Jegga"],"firstnames":["Anil","G"],"suffixes":[]},{"propositions":[],"lastnames":["Yu"],"firstnames":["Jing"],"suffixes":[]},{"propositions":[],"lastnames":["Grimmond"],"firstnames":["Sean"],"suffixes":[]},{"propositions":[],"lastnames":["McMahon"],"firstnames":["Andrew","P"],"suffixes":[]},{"propositions":[],"lastnames":["Patterson"],"firstnames":["Larry","T"],"suffixes":[]},{"propositions":[],"lastnames":["Little"],"firstnames":["Melissa","H"],"suffixes":[]},{"propositions":[],"lastnames":["Potter"],"firstnames":["S","Steven"],"suffixes":[]}],"title":"Atlas of gene expression in the developing kidney at microanatomic resolution.","journal":"Developmental cell","year":"2008","volume":"15","number":"5","pages":"781--791","month":"November","affiliation":"Division of Developmental Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.","doi":"10.1016/j.devcel.2008.09.007","pmid":"19000842","pmcid":"PMC2653061","language":"English","read":"Yes","rating":"0","date-added":"2009-01-25T21:41:29GMT","date-modified":"2016-12-06T21:44:37GMT","abstract":"Kidney development is based on differential cell-type-specific expression of a vast number of genes. While multiple critical genes and pathways have been elucidated, a genome-wide analysis of gene expression within individual cellular and anatomic structures is lacking. Accomplishing this could provide significant new insights into fundamental developmental mechanisms such as mesenchymal-epithelial transition, inductive signaling, branching morphogenesis, and segmentation. We describe here a comprehensive gene expression atlas of the developing mouse kidney based on the isolation of each major compartment by either laser capture microdissection or fluorescence-activated cell sorting, followed by microarray profiling. The resulting data agree with known expression patterns and additional in situ hybridizations. This kidney atlas allows a comprehensive analysis of the progression of gene expression states during nephrogenesis, as well as discovery of potential growth factor-receptor interactions. In addition, the results provide deeper insight into the genetic regulatory mechanisms of kidney development.","url":"<a href=\"http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19000842&retmode=ref&cmd=prlinks","key":"Brunskill:2008gc","id":"Brunskill:2008gc","bibbaseid":"anonymous-atlasofgeneexpressioninthedevelopingkidneyatmicroanatomicresolution-2008","role":"author","urls":{"Paper":"http://valeriuslab.org/%3Ca%20href=%22http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19000842&retmode=ref&cmd=prlinks"},"downloads":0},"search_terms":["atlas","gene","expression","developing","kidney","microanatomic","resolution"],"keywords":[],"authorIDs":[],"dataSources":["jZDZpEMgY2oLZZRMD"]}