{"_id":"6vDN68HjdwNZTrdj4","bibbaseid":"anonymous-effectofalphalactalbuminandlactoferrinoleicacidcomplexesonchromatinstructuralorganization-2019","authorIDs":[],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Lebedev"],"firstnames":["D.V."],"suffixes":[]},{"propositions":[],"lastnames":["Zabrodskaya"],"firstnames":["Y.A."],"suffixes":[]},{"propositions":[],"lastnames":["Pipich"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Kuklin"],"firstnames":["A.I."],"suffixes":[]},{"propositions":[],"lastnames":["Ramsay"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Sokolov"],"firstnames":["A.V."],"suffixes":[]},{"propositions":[],"lastnames":["Elizarova"],"firstnames":["A.Y."],"suffixes":[]},{"propositions":[],"lastnames":["Shaldzhyan"],"firstnames":["A.A."],"suffixes":[]},{"propositions":[],"lastnames":["Grudinina"],"firstnames":["N.A."],"suffixes":[]},{"propositions":[],"lastnames":["Pantina"],"firstnames":["R.A."],"suffixes":[]},{"propositions":[],"lastnames":["Wu"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Shtam"],"firstnames":["T.A."],"suffixes":[]},{"propositions":[],"lastnames":["Volnitskiy"],"firstnames":["A.V."],"suffixes":[]},{"propositions":[],"lastnames":["Schmidt"],"firstnames":["A.E."],"suffixes":[]},{"propositions":[],"lastnames":["Shvetsov"],"firstnames":["A.V."],"suffixes":[]},{"propositions":[],"lastnames":["Vasilyev"],"firstnames":["V.B."],"suffixes":[]},{"propositions":[],"lastnames":["Isaev-Ivanov"],"firstnames":["V.V."],"suffixes":[]},{"propositions":[],"lastnames":["Egorov"],"firstnames":["V.V."],"suffixes":[]}],"title":"Effect of alpha-lactalbumin and lactoferrin oleic acid complexes on chromatin structural organization","journal":"Biochemical and Biophysical Research Communications","year":"2019","volume":"520","number":"1","pages":"136-139","doi":"10.1016/j.bbrc.2019.09.116","note":"cited By 0","url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072708276&doi=10.1016%2fj.bbrc.2019.09.116&partnerID=40&md5=a06fb06bdcf8a8d38c05dce20a1ca016","affiliation":"Department of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute Named by B. P. Konstantinov of National Research Center “Kurchatov Institute”, mkr. Orlova roshcha 1, Gatchina, 188300, Russian Federation; National Research Centre Kurchatov Institute, Akademika Kurchatova Sq. 1, Moscow, 123182, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, Politekhnicheskaya 29, St. Petersburg, 194064, Russian Federation; Department of Molecular Biology of Viruses, Smorodintsev Research Institute of Influenza, Russian Ministry of Health, Prof. Popov St. 15/17, St. Petersburg, 197376, Russian Federation; Jülich Centre for Neutron Science at Heinz Maier-Leibnitz Zentrum, Lichtenbergstr. 1, Garching, Munich D-85747, Germany; Frank Laboratory of Neutron Physics, International Intergovernmental Organization Joint Institute for Nuclear Research, Joliot-Curie St. 6, Moscow Region, Dubna, 141980, Russian Federation; Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, Dolgoprudny, Moscow Region 141701, Russian Federation; Department of Molecular Genetics, Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”, Akademika Pavlova St. 12, St. Petersburg, 197376, Russian Federation; St. Petersburg University, Universitetskaya Emb. 7-9, St Petersburg, 199034, Russian Federation","abstract":"This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. Complexes featuring oleic acid (OA) with human alpha-lactalbumin (hAl) or with bovine alpha-lactalbumin (bAl), and human lactoferrin (hLf) were investigated using small-angle neutron scattering (SANS). It was shown that while alpha-lactalbumin protein complexes were formed on the surface of polydisperse OA micelles, the lactoferrin complexes comprised a monodisperse system of nanoscale particles. Both hAl and hLf complexes appeared to interact with the chromatin of isolated nuclei affecting chromatin structural organization. The possible roles of these processes in the specific anti-tumor activity of these complexes are discussed. © 2019 Elsevier Inc.","author_keywords":"Antitumor agents; Chromatin structural organization; Lactalbumin; Lactoferrin; Oleic acid","funding_details":"National Rehabilitation Center1363","key":"Lebedev2019136","id":"Lebedev2019136","bibbaseid":"anonymous-effectofalphalactalbuminandlactoferrinoleicacidcomplexesonchromatinstructuralorganization-2019","role":"author","urls":{"Paper":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072708276&doi=10.1016%2fj.bbrc.2019.09.116&partnerID=40&md5=a06fb06bdcf8a8d38c05dce20a1ca016"},"metadata":{"authorlinks":{}},"downloads":4},"bibtype":"article","biburl":"https://bio.pnpi.nrcki.ru/wp-content/uploads/2019/12/lge_2019_10.txt","creationDate":"2019-11-05T13:18:15.219Z","downloads":4,"keywords":[],"search_terms":["effect","alpha","lactalbumin","lactoferrin","oleic","acid","complexes","chromatin","structural","organization"],"title":"Effect of alpha-lactalbumin and lactoferrin oleic acid complexes on chromatin structural organization","year":2019,"dataSources":["TRehu3DvnmfePetpJ","YYLjupmCazkNqWNEJ","cJ5ZpoJMJycEnWRby","iLRJFpu2xNha2Yjaa"]}