{"_id":"FrKo4wmLseq3obSRE","bibbaseid":"anonymous-optimisedproceduresforthereversedphaseliquidchromatographicanalysisofformulationscontainingtricyclicantidepressants-2003","bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Ruiz-Angel"],"firstnames":["M.J."],"suffixes":[]},{"propositions":[],"lastnames":["Carda-Broch"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Simó-Alfonso"],"firstnames":["E.F."],"suffixes":[]},{"propositions":[],"lastnames":["García-Alvarez-Coque"],"firstnames":["M.C."],"suffixes":[]}],"title":"Optimised procedures for the reversed-phase liquid chromatographic analysis of formulations containing tricyclic antidepressants","journal":"Journal of Pharmaceutical and Biomedical Analysis","year":"2003","volume":"32","number":"1","pages":"71-84","doi":"10.1016/S0731-7085(03)00048-7","note":"cited By 47","url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-0344520388&doi=10.1016%2fS0731-7085%2803%2900048-7&partnerID=40&md5=7fc49fd2e431c9a71bf274c46f83a92e","affiliation":"Facultat de Química, Dept. de Quim. Analitica, Universitat de València, Dr. Moliner 50, Burjassot, Valencia 46100, Spain; Area de Quim. Analitica, Universitat Jaume I, Cra. Borriol s/n, Castelló 12080, Spain","abstract":"The chromatographic behaviour (retention, selectivity, peak shape and resolution) of seven tricyclic antidepressants (TCAs), amitryptiline, clomipramine, doxepin, imipramine, maprotiline, nortryptiline and trimipramine, was examined. Conventional unendcapped C8 and C18 columns and an endcapped XTerra MS C18 column recommended for the analysis of basic compounds were used together with acetonitrile-water and micellar sodium dodecylsulfate (SDS)-pentanol mobile phases. The two best combinations were XTerra C18/acetonitrile, which yielded the largest efficiencies and resolution, and C8/SDS-pentanol, which eliminated the peak tails that were still observed with the XTerra C18 column. Both the systems were used to develop simple chromatographic procedures for the control of TCAs in pharmaceutical formulations using UV detection. The selected mobile phase compositions were 35% (v/v) acetonitrile (XTerra C18 column) and 0.075 M SDS-6% (v/v) pentanol (C8 column), both at pH 3. Satisfactory recoveries were achieved in both cases, with intra- and inter-day relative standard deviations (RSDs) always below 0.6 and 2.0%, respectively. The preparation of the samples was simple in both modes, since a previous extraction of the drugs was not needed. The micellar mode has, however, the advantage of using a smaller amount of organic solvent, which is retained in the micellar SDS solution. The C8 column is also less expensive. © 2003 Elsevier Science B.V. All rights reserved.","author_keywords":"Acetonitrile; Formulations; Pentanol; Reversed-phase liquid chromatography; Sodium dodecylsulfate; Tricyclic antidepressants","keywords":"acetonitrile; amitriptyline; clomipramine; dodecyl sulfate sodium; doxepin; imipramine; maprotiline; nortriptyline; pentanol; tricyclic antidepressant agent; trimipramine; water, article; drug analysis; drug formulation; drug isolation; micelle; pH; priority journal; reversed phase liquid chromatography","chemicals_cas":"acetonitrile, 75-05-8; amitriptyline, 50-48-6, 549-18-8; clomipramine, 17321-77-6, 303-49-1; dodecyl sulfate sodium, 151-21-3; doxepin, 1229-29-4, 1668-19-5; imipramine, 113-52-0, 50-49-7; maprotiline, 10262-69-8, 10347-81-6; nortriptyline, 72-69-5, 894-71-3; pentanol, 30899-19-5, 51152-16-0, 71-41-0; trimipramine, 25332-13-2, 521-78-8, 739-71-9; water, 7732-18-5","funding_details":"European Regional Development FundEuropean Regional Development Fund, FEDER, CTIDIB/2002/226","key":"Ruiz-Angel200371","id":"Ruiz-Angel200371","bibbaseid":"anonymous-optimisedproceduresforthereversedphaseliquidchromatographicanalysisofformulationscontainingtricyclicantidepressants-2003","role":"author","urls":{"Paper":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-0344520388&doi=10.1016%2fS0731-7085%2803%2900048-7&partnerID=40&md5=7fc49fd2e431c9a71bf274c46f83a92e"},"keyword":["acetonitrile; amitriptyline; clomipramine; dodecyl sulfate sodium; doxepin; imipramine; maprotiline; nortriptyline; pentanol; tricyclic antidepressant agent; trimipramine; water","article; drug analysis; drug formulation; drug isolation; micelle; pH; priority journal; reversed phase liquid chromatography"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://www.clecem.es/wp-content/uploads/2024/01/scopus.bib","dataSources":["z88YG74vvXjjYpRcn"],"keywords":["acetonitrile; amitriptyline; clomipramine; dodecyl sulfate sodium; doxepin; imipramine; maprotiline; nortriptyline; pentanol; tricyclic antidepressant agent; trimipramine; water","article; drug analysis; drug formulation; drug isolation; micelle; ph; priority journal; reversed phase liquid chromatography"],"search_terms":["optimised","procedures","reversed","phase","liquid","chromatographic","analysis","formulations","containing","tricyclic","antidepressants"],"title":"Optimised procedures for the reversed-phase liquid chromatographic analysis of formulations containing tricyclic antidepressants","year":2003}