{"_id":"sZFGucJ67q7q3qDJh","bibbaseid":"anonymous-proliferatingcellnuclearantigeninthecytoplasminteractswithcomponentsofglycolysisandcancer-2010","bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Naryzhny"],"firstnames":["S.N."],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["H."],"suffixes":[]}],"title":"Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer","journal":"FEBS Letters","year":"2010","volume":"584","number":"20","pages":"4292-4298","doi":"10.1016/j.febslet.2010.09.021","note":"cited By 39","url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-77957792618&doi=10.1016%2fj.febslet.2010.09.021&partnerID=40&md5=6b76a03c6ba1db262d942be7e38047e9","affiliation":"Northeastern Ontario Regional Cancer Centre, Sudbury Regional Hospital, 41 Ramsey Lake Road, Sudbury, Ontario, P3E 5J1, Canada; Medical Sciences Division, Northern Ontario School of Medicine, 935 Ramsey Lake Road, Sudbury, Ontario, P3E 2C6, Canada; Molecular and Radiation Biophysics Department, Petersburg Nuclear Physics Institute, Leningrad district, Gatchina, 188300, Russian Federation","abstract":"Proliferating cell nuclear antigen (PCNA) is involved in a wide range of functions in the nucleus. However, a substantial amount of PCNA is also present in the cytoplasm, although their function is unknown. Here we show, through Far-Western blotting and mass spectrometry, that PCNA is associated with several cytoplasmic oncoproteins, including elongation factor, malate dehydrogenase, and peptidyl-prolyl isomerase. Surprisingly, PCNA is also associated with six glycolytic enzymes that are involved in the regulation of steps 4-9 in the glycolysis pathway. Structured summary: MINT-7995351: G3P (uniprotkb:. P04406) and PCNA (uniprotkb:. P12004) colocalize (MI:. 0403) by fluorescence microscopy (MI:. 0416)MINT-7995334: ENOA (uniprotkb:. P06733) and PCNA (uniprotkb:. P12004) colocalize (MI:. 0403) by fluorescence microscopy (MI:. 0416)MINT-7995368: ALDOA (uniprotkb:. P04075) and PCNA (uniprotkb:. P12004) colocalize (MI:. 0403) by fluorescence microscopy (MI:. 0416)MINT-7995141: G3P (uniprotkb:. P04406) binds (MI:. 0407) to PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995182: ENOA (uniprotkb:. P06733) binds (MI:. 0407) to PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995132: G3P (uniprotkb:. P04406) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995228: PRDX6 (uniprotkb:. P30041) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995220: CAH2 (uniprotkb:. P00918) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995114: Triosephosphate isomerase (uniprotkb:. P60174) binds (MI:. 0407) to PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995244: K2C7 (uniprotkb:. P08729) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995252: ANXA2 (uniprotkb:. P07355) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995122: Triosephosphate isomerase (uniprotkb:. P60174) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995093: ALDOA (uniprotkb:. P04075) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995148: PGK1 (uniprotkb:. P00558) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995158: PGAM1 (uniprotkb:. P18669)physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995166: PGAM1 (uniprotkb:. P18669) binds (MI:. 0407) to PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995105: ALDOA (uniprotkb:. P04075) binds (MI:. 0407) to PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995260: PPIA (uniprotkb:. P62937) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995173: ENOA (uniprotkb:. P06733) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995268: EF1A (uniprotkb:. P68104) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995236: MDHM (uniprotkb:. P40926) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995189: RSSA (uniprotkb:. P08865) physically interacts (MI:. 0915) with PCNA (uniprotkb:. P12004) by far western blotting (MI:. 0047)MINT-7995282: PCNA (uniprotkb:. P12004) physically interacts (MI:. 0915) with ALDOA (uniprotkb:. P00883) and G3P (uniprotkb:. P46406) by anti bait coimmunoprecipitation (MI:. 0006). © 2010 Federation of European Biochemical Societies.","author_keywords":"Far-Western blot; Glycolysis; Mass spectrometry; PCNA; Protein-protein interaction; Two dimensional (2D) gel electrophoresis","funding_details":"Canadian Institutes of Health ResearchMOP79473","key":"Naryzhny20104292","id":"Naryzhny20104292","bibbaseid":"anonymous-proliferatingcellnuclearantigeninthecytoplasminteractswithcomponentsofglycolysisandcancer-2010","role":"author","urls":{"Paper":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-77957792618&doi=10.1016%2fj.febslet.2010.09.021&partnerID=40&md5=6b76a03c6ba1db262d942be7e38047e9"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bio.pnpi.nrcki.ru/wp-content/uploads/2019/12/lpro_2019_10.txt","dataSources":["eoAALb5LHAEShrPHa"],"keywords":[],"search_terms":["proliferating","cell","nuclear","antigen","cytoplasm","interacts","components","glycolysis","cancer"],"title":"Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer","year":2010}