A 12-week multidomain intervention versus active control to reduce risk of Alzheimer’s disease: study protocol for a randomized controlled trial. Anstey, K. J., Bahar-Fuchs, A., Herath, P., Rebok, G. W., & Cherbuin, N. Trials, 14:60, 2013. Multi![A 12-week multidomain intervention versus active control to reduce risk of Alzheimer’s disease: study protocol for a randomized controlled trial [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Disappointing results from clinical trials of disease-modifying interventions for Alzheimer’s dementia (AD), along with reliable identification of modifiable risk factors in mid life from epidemiological studies, have contributed to calls to invest in risk-reduction interventions. It is also well known that AD-related pathological processes begin more than a decade before the development of clinical signs. These observations suggest that lifestyle interventions might be most effective when targeting non-symptomatic adults at risk of AD. To date, however, the few dementia risk-reduction programs available have targeted individual risk factors and/or were restricted to clinical settings. The current study describes the development of an evidence-based, theoretically-driven multidomain intervention to reduce AD risk in adults at risk.
@article{anstey_12-week_2013,
title = {A 12-week multidomain intervention versus active control to reduce risk of {Alzheimer}’s disease: study protocol for a randomized controlled trial},
volume = {14},
issn = {1745-6215},
shorttitle = {A 12-week multidomain intervention versus active control to reduce risk of {Alzheimer}’s disease},
url = {http://dx.doi.org/10.1186/1745-6215-14-60},
doi = {10.1186/1745-6215-14-60},
abstract = {Disappointing results from clinical trials of disease-modifying interventions for Alzheimer’s dementia (AD), along with reliable identification of modifiable risk factors in mid life from epidemiological studies, have contributed to calls to invest in risk-reduction interventions. It is also well known that AD-related pathological processes begin more than a decade before the development of clinical signs. These observations suggest that lifestyle interventions might be most effective when targeting non-symptomatic adults at risk of AD. To date, however, the few dementia risk-reduction programs available have targeted individual risk factors and/or were restricted to clinical settings. The current study describes the development of an evidence-based, theoretically-driven multidomain intervention to reduce AD risk in adults at risk.},
urldate = {2017-02-08},
journal = {Trials},
author = {Anstey, Kaarin J. and Bahar-Fuchs, Alex and Herath, Pushpani and Rebok, George W. and Cherbuin, Nicolas},
year = {2013},
note = {Multi},
keywords = {Alzheimer’s Disease, Behavior change, Cardiovascular risk factors, Diet, Internet, RCT, physical activity},
pages = {60}
}
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