Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Anti, M., Marra, G., Armelao, F., Bartoli, G. M., Ficarelli, R., Percesepe, A., De Vitis, I., Maria, G., Sofo, L., & Rapaccini, G. L. Gastroenterology, 103(3):883–891, September, 1992. abstract bibtex The effects of 12 weeks of omega-3 fatty acid supplementation on rectal mucosal proliferation were assessed with [3H]thymidine autoradiography in a double-blind, placebo-controlled study of 20 patients with sporadic adenomatous colorectal polyps. In the group of 10 that received fish oil containing eicosapentaenoic acid (4.1 g/day) and docosahexaenoic acid (3.6 g/day), the mean percentage of replicative "S"-phase cells in the upper part of colonic crypts (considered a reliable marker of colon cancer risk) significantly dropped from the baseline level after only 2 weeks of treatment and remained lower throughout the study period; no change in upper-crypt labeling was observed in the 10 placebo patients. Rectal mucosal eicosapentaenoic acid content increased in fish oil patients, whereas arachidonic acid levels decreased. The fish oil-induced kinetic changes represent contraction of the proliferative compartment to the levels of a low-risk population and may be related to omega-3 fatty acid effects on the arachidonic prostaglandin pathway. In this short-term trial, fish oil appeared to exert a rapid effect that may protect high-risk subjects from colon cancer.
@article{anti_effect_1992,
title = {Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer},
volume = {103},
issn = {0016-5085},
abstract = {The effects of 12 weeks of omega-3 fatty acid supplementation on rectal mucosal proliferation were assessed with [3H]thymidine autoradiography in a double-blind, placebo-controlled study of 20 patients with sporadic adenomatous colorectal polyps. In the group of 10 that received fish oil containing eicosapentaenoic acid (4.1 g/day) and docosahexaenoic acid (3.6 g/day), the mean percentage of replicative "S"-phase cells in the upper part of colonic crypts (considered a reliable marker of colon cancer risk) significantly dropped from the baseline level after only 2 weeks of treatment and remained lower throughout the study period; no change in upper-crypt labeling was observed in the 10 placebo patients. Rectal mucosal eicosapentaenoic acid content increased in fish oil patients, whereas arachidonic acid levels decreased. The fish oil-induced kinetic changes represent contraction of the proliferative compartment to the levels of a low-risk population and may be related to omega-3 fatty acid effects on the arachidonic prostaglandin pathway. In this short-term trial, fish oil appeared to exert a rapid effect that may protect high-risk subjects from colon cancer.},
language = {eng},
number = {3},
journal = {Gastroenterology},
author = {Anti, M. and Marra, G. and Armelao, F. and Bartoli, G. M. and Ficarelli, R. and Percesepe, A. and De Vitis, I. and Maria, G. and Sofo, L. and Rapaccini, G. L.},
month = sep,
year = {1992},
pmid = {1386825},
keywords = {Autoradiography, Cell Division, Colorectal Neoplasms, Docosahexaenoic Acids, Double-Blind Method, Drug Administration Schedule, Eicosapentaenoic Acid, Humans, Intestinal Mucosa, Intestinal Polyps, Rectum, S Phase},
pages = {883--891},
}
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In the group of 10 that received fish oil containing eicosapentaenoic acid (4.1 g/day) and docosahexaenoic acid (3.6 g/day), the mean percentage of replicative \"S\"-phase cells in the upper part of colonic crypts (considered a reliable marker of colon cancer risk) significantly dropped from the baseline level after only 2 weeks of treatment and remained lower throughout the study period; no change in upper-crypt labeling was observed in the 10 placebo patients. Rectal mucosal eicosapentaenoic acid content increased in fish oil patients, whereas arachidonic acid levels decreased. The fish oil-induced kinetic changes represent contraction of the proliferative compartment to the levels of a low-risk population and may be related to omega-3 fatty acid effects on the arachidonic prostaglandin pathway. 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