Novel <i>YAP1‐TFE3</i> fusion defines a distinct subset of epithelioid hemangioendothelioma. Antonescu, C. R., Le Loarer, F., Mosquera, J., Sboner, A., Zhang, L., Chen, C., Chen, H., Pathan, N., Krausz, T., Dickson, B. C., Weinreb, I., Rubin, M. A., Hameed, M., & Fletcher, C. D. M. Genes, Chromosomes and Cancer, 52(8):775–784, August, 2013.
Novel <i>YAP1‐TFE3</i> fusion defines a distinct subset of epithelioid hemangioendothelioma [link]Paper  doi  abstract   bibtex   
Conventional epithelioid hemangioendotheliomas (EHE) have a distinctive morphologic appearance and are characterized by a recurrent t(1;3) translocation, resulting in a WWTR1‐CAMTA1 fusion gene. We have recently encountered a fusion‐negative subset characterized by a somewhat different morphology, including focally well‐formed vasoformative features, which was further investigated for recurrent genetic abnormalities. Based on a case showing strong transcription factor E3 (TFE3) immunoreactivity, fluorescence in situ hybridization (FISH) analysis for TFE3 gene rearrangement was applied to the index case as well as to nine additional cases, selected through negative WWTR1‐CAMTA1 screening. A control group, including 18 epithelioid hemangiomas, nine pseudomyogenic HE, and three epithelioid angiosarcomas, was also tested. TFE3 gene rearrangement was identified in 10 patients, with equal gender distribution and a mean age of 30 years old. The lesions were located in somatic soft tissue in six cases, lung in three and one in bone. One case with available frozen tissue was tested by RNA sequencing and FusionSeq data analysis to detect novel fusions. A YAP1‐TFE3 fusion was thus detected, which was further validated by FISH and reverse transcription polymerase chain reaction (RT‐PCR). YAP1 gene rearrangements were then confirmed in seven of the remaining nine TFE3 ‐rearranged EHEs by FISH. No TFE3 structural abnormalities were detected in any of the controls. The TFE3 ‐rearranged EHEs showed similar morphologic features with at least focally, well‐formed vascular channels, in addition to a variably solid architecture. All tumors expressed endothelial markers, as well as strong nuclear TFE3. In summary, we are reporting a novel subset of EHE occurring in young adults, showing a distinct phenotype and YAP1‐TFE3 fusions. © 2013 Wiley Periodicals, Inc.
@article{antonescu_novel_2013,
	title = {Novel \textit{{YAP1}‐{TFE3}} fusion defines a distinct subset of epithelioid hemangioendothelioma},
	volume = {52},
	copyright = {http://onlinelibrary.wiley.com/termsAndConditions\#vor},
	issn = {1045-2257, 1098-2264},
	url = {https://onlinelibrary.wiley.com/doi/10.1002/gcc.22073},
	doi = {10.1002/gcc.22073},
	abstract = {Conventional epithelioid hemangioendotheliomas (EHE) have a distinctive morphologic appearance and are characterized by a recurrent t(1;3) translocation, resulting in a
              WWTR1‐CAMTA1
              fusion gene. We have recently encountered a fusion‐negative subset characterized by a somewhat different morphology, including focally well‐formed vasoformative features, which was further investigated for recurrent genetic abnormalities. Based on a case showing strong transcription factor E3 (TFE3) immunoreactivity, fluorescence in situ hybridization (FISH) analysis for
              TFE3
              gene rearrangement was applied to the index case as well as to nine additional cases, selected through negative
              WWTR1‐CAMTA1
              screening. A control group, including 18 epithelioid hemangiomas, nine pseudomyogenic HE, and three epithelioid angiosarcomas, was also tested.
              TFE3
              gene rearrangement was identified in 10 patients, with equal gender distribution and a mean age of 30 years old. The lesions were located in somatic soft tissue in six cases, lung in three and one in bone. One case with available frozen tissue was tested by RNA sequencing and FusionSeq data analysis to detect novel fusions. A
              YAP1‐TFE3
              fusion was thus detected, which was further validated by FISH and reverse transcription polymerase chain reaction (RT‐PCR).
              YAP1
              gene rearrangements were then confirmed in seven of the remaining nine
              TFE3
              ‐rearranged EHEs by FISH. No
              TFE3
              structural abnormalities were detected in any of the controls. The
              TFE3
              ‐rearranged EHEs showed similar morphologic features with at least focally, well‐formed vascular channels, in addition to a variably solid architecture. All tumors expressed endothelial markers, as well as strong nuclear TFE3. In summary, we are reporting a novel subset of EHE occurring in young adults, showing a distinct phenotype and
              YAP1‐TFE3
              fusions. © 2013 Wiley Periodicals, Inc.},
	language = {en},
	number = {8},
	urldate = {2024-12-06},
	journal = {Genes, Chromosomes and Cancer},
	author = {Antonescu, Cristina R. and Le Loarer, Francois and Mosquera, Juan‐Miguel and Sboner, Andrea and Zhang, Lei and Chen, Chun‐Liang and Chen, Hsiao‐Wei and Pathan, Nursat and Krausz, Thomas and Dickson, Brendan C. and Weinreb, Ilan and Rubin, Mark A. and Hameed, Meera and Fletcher, Christopher D. M.},
	month = aug,
	year = {2013},
	pages = {775--784},
}
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