@article{
 title = {RADIomic Spatial TexturAl Descriptor (RADISTAT): Quantifying Spatial Organization of Imaging Heterogeneity Associated With Tumor Response to Treatment},
 type = {article},
 year = {2022},
 keywords = {Glioblastoma multiforme,graph organization,radiomics,rectal cancer,response characterization,tumor heterogeneity},
 volume = {26},
 id = {f3534902-e97c-3d2b-927e-a4b794232917},
 created = {2023-10-25T08:56:38.021Z},
 file_attached = {false},
 profile_id = {eaba325f-653b-3ee2-b960-0abd5146933e},
 last_modified = {2023-10-25T08:56:38.021Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {true},
 abstract = {Localized disease heterogeneity on imaging extracted via radiomics approaches have recently been associated with disease prognosis and treatment response. Traditionally, radiomics analyses leverage texture operators to derive voxel- or region-wise feature values towards quantifying subtle variations in image appearance within a region-of-interest (ROI). With the goal of mining additional voxel-wise texture patterns from radiomic 'expression maps', we introduce a new RADIomic Spatial TexturAl descripTor (RADISTAT). This was driven by the hypothesis that quantifying spatial organization of texture patterns within an ROI could allow for better capturing interactions between different tissue classes present in a given region; thus enabling more accurate characterization of disease or response phenotypes. RADISTAT involves: (a) robustly identifying sub-compartments of low, intermediate, and high radiomic expression (i.e. heterogeneity) in a feature map and (b) quantifying spatial organization of sub-compartments via graph interactions. RADISTAT was evaluated in two clinically challenging problems: (1) discriminating nodal/distant metastasis from metastasis-free rectal cancer patients on post-chemoradiation T2w MRI, and (2) distinguishing tumor progression from pseudo-progression in glioblastoma multiforme using post-chemoradiation T1w MRI. Across over 800 experiments, RADISTAT yielded a consistent discriminatory signature for tumor progression (GBM) and disease metastasis (RCa); where its sub-compartments were associated with pathologic tissue types (fibrosis or tumor, determined via fusion of MRI and pathology). In a multi-institutional setting for both clinical problems, RADISTAT resulted in higher classifier performance (11% improvement in AUC, on average) compared to radiomic descriptors. Furthermore, combining RADISTAT with radiomic descriptors resulted in significantly improved performance compared to using radiomic descriptors alone.},
 bibtype = {article},
 author = {Antunes, J.T. and Ismail, M. and Hossain, I. and Wang, Z. and Prasanna, P. and Madabhushi, A. and Tiwari, P. and Viswanath, S.E.},
 doi = {10.1109/JBHI.2022.3146778},
 journal = {IEEE Journal of Biomedical and Health Informatics},
 number = {6}
}

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Traditionally, radiomics analyses leverage texture operators to derive voxel- or region-wise feature values towards quantifying subtle variations in image appearance within a region-of-interest (ROI). With the goal of mining additional voxel-wise texture patterns from radiomic 'expression maps', we introduce a new RADIomic Spatial TexturAl descripTor (RADISTAT). This was driven by the hypothesis that quantifying spatial organization of texture patterns within an ROI could allow for better capturing interactions between different tissue classes present in a given region; thus enabling more accurate characterization of disease or response phenotypes. RADISTAT involves: (a) robustly identifying sub-compartments of low, intermediate, and high radiomic expression (i.e. heterogeneity) in a feature map and (b) quantifying spatial organization of sub-compartments via graph interactions. RADISTAT was evaluated in two clinically challenging problems: (1) discriminating nodal/distant metastasis from metastasis-free rectal cancer patients on post-chemoradiation T2w MRI, and (2) distinguishing tumor progression from pseudo-progression in glioblastoma multiforme using post-chemoradiation T1w MRI. Across over 800 experiments, RADISTAT yielded a consistent discriminatory signature for tumor progression (GBM) and disease metastasis (RCa); where its sub-compartments were associated with pathologic tissue types (fibrosis or tumor, determined via fusion of MRI and pathology). In a multi-institutional setting for both clinical problems, RADISTAT resulted in higher classifier performance (11% improvement in AUC, on average) compared to radiomic descriptors. Furthermore, combining RADISTAT with radiomic descriptors resulted in significantly improved performance compared to using radiomic descriptors alone.","bibtype":"article","author":"Antunes, J.T. and Ismail, M. and Hossain, I. and Wang, Z. and Prasanna, P. and Madabhushi, A. and Tiwari, P. and Viswanath, S.E.","doi":"10.1109/JBHI.2022.3146778","journal":"IEEE Journal of Biomedical and Health Informatics","number":"6","bibtex":"@article{\n title = {RADIomic Spatial TexturAl Descriptor (RADISTAT): Quantifying Spatial Organization of Imaging Heterogeneity Associated With Tumor Response to Treatment},\n type = {article},\n year = {2022},\n keywords = {Glioblastoma multiforme,graph organization,radiomics,rectal cancer,response characterization,tumor heterogeneity},\n volume = {26},\n id = {f3534902-e97c-3d2b-927e-a4b794232917},\n created = {2023-10-25T08:56:38.021Z},\n file_attached = {false},\n profile_id = {eaba325f-653b-3ee2-b960-0abd5146933e},\n last_modified = {2023-10-25T08:56:38.021Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n private_publication = {true},\n abstract = {Localized disease heterogeneity on imaging extracted via radiomics approaches have recently been associated with disease prognosis and treatment response. 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