Imaging of neural ensemble for the retrieval of a learned behavioral program. Aoki, T., Kinoshita, M., Aoki, R., Agetsuma, M., Aizawa, H., Yamazaki, M., Takahoko, M., Amo, R., Arata, A., Higashijima, S., Tsuboi, T., & Okamoto, H. Neuron, 78(5):881–94, June, 2013.
Imaging of neural ensemble for the retrieval of a learned behavioral program. [link]Paper  doi  abstract   bibtex   
The encoding of long-term associative memories for learned behaviors is a fundamental brain function. Yet, how behavior is stably consolidated and retrieved in the vertebrate cortex is poorly understood. We trained zebrafish in aversive reinforcement learning and measured calcium signals across their entire brain during retrieval of the learned response. A discrete area of dorsal telencephalon that was inactive immediately after training became active the next day. Analysis of the identified area indicated that it was specific and essential for long-term memory retrieval and contained electrophysiological responses entrained to the learning stimulus. When the behavioral rule changed, a rapid spatial shift in the functional map across the telencephalon was observed. These results demonstrate that the retrieval of long-term memories for learned behaviors can be studied at the whole-brain scale in behaving zebrafish in vivo. Moreover, the findings indicate that consolidated memory traces can be rapidly modified during reinforcement learning.
@article{Aoki2013,
	title = {Imaging of neural ensemble for the retrieval of a learned behavioral program.},
	volume = {78},
	issn = {1097-4199},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23684786},
	doi = {10.1016/j.neuron.2013.04.009},
	abstract = {The encoding of long-term associative memories for learned behaviors is a fundamental brain function. Yet, how behavior is stably consolidated and retrieved in the vertebrate cortex is poorly understood. We trained zebrafish in aversive reinforcement learning and measured calcium signals across their entire brain during retrieval of the learned response. A discrete area of dorsal telencephalon that was inactive immediately after training became active the next day. Analysis of the identified area indicated that it was specific and essential for long-term memory retrieval and contained electrophysiological responses entrained to the learning stimulus. When the behavioral rule changed, a rapid spatial shift in the functional map across the telencephalon was observed. These results demonstrate that the retrieval of long-term memories for learned behaviors can be studied at the whole-brain scale in behaving zebrafish in vivo. Moreover, the findings indicate that consolidated memory traces can be rapidly modified during reinforcement learning.},
	number = {5},
	urldate = {2014-01-23},
	journal = {Neuron},
	author = {Aoki, Tazu and Kinoshita, Masae and Aoki, Ryo and Agetsuma, Masakazu and Aizawa, Hidenori and Yamazaki, Masako and Takahoko, Mikako and Amo, Ryunosuke and Arata, Akiko and Higashijima, Shin-ichi and Tsuboi, Takashi and Okamoto, Hitoshi},
	month = jun,
	year = {2013},
	pmid = {23684786},
	keywords = {\#nosource, Action Potentials, Action Potentials: genetics, Animals, Animals, Genetically Modified, Avoidance Learning, Avoidance Learning: physiology, Biotin, Biotin: metabolism, Brain, Brain Mapping, Brain: cytology, Brain: physiology, Brain: surgery, Calcium, Calcium Signaling, Calcium Signaling: genetics, Calcium: metabolism, Cues, Electrolysis, Escape Reaction, Escape Reaction: physiology, Functional Laterality, Functional Laterality: genetics, Glutamate Decarboxylase, Glutamate Decarboxylase: genetics, Glutamate Decarboxylase: metabolism, Hu Paraneoplastic Encephalomyelitis Antigens, Hu Paraneoplastic Encephalomyelitis Antigens: gene, Hu Paraneoplastic Encephalomyelitis Antigens: meta, Mental Recall, Mental Recall: physiology, Neuroimaging, Neurons, Neurons: physiology, Parvalbumins, Parvalbumins: metabolism, Patch-Clamp Techniques, Swimming, Swimming: physiology, Time Factors, Vesicular Glutamate Transport Proteins, Vesicular Glutamate Transport Proteins: genetics, Vesicular Glutamate Transport Proteins: metabolism, Zebrafish, adult learning},
	pages = {881--94},
}
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