Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases. Apsel, B., Blair, J., Gonzalez, B., Nazif, T., Feldman, M., Aizenstein, B., Hoffman, R., Williams, R., Shokat, K., & Knight, Z. Nat.~Chem.~Biol., 4(11):691--699, Nature Publishing Group, 11, 2008. ![Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper bibtex @article{Apsel:2008dn,
Author = {Apsel, Beth and Blair, Jimmy and Gonzalez, Beatriz and Nazif, Tamim and Feldman, Morri and Aizenstein, Brian and Hoffman, Randy and Williams, Roger and Shokat, Kevan and Knight, Zachary},
Date-Added = {2009-07-26 20:27:25 -0400},
Date-Modified = {2009-07-26 20:27:25 -0400},
Id = {citeulike:3578400},
Journal = {Nat.~Chem.~Biol.},
Keywords = {kinase; polypharmacology},
L3 = {citeulike-article-id:3578400},
Month = {11},
Number = {11},
Pages = {691--699},
Publisher = {Nature Publishing Group},
Title = {Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases},
Ty = {JOUR},
Url = {http://dx.doi.org/10.1038/nchembio.117},
Volume = {4},
Year = {2008},
Bdsk-File-1 = {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},
Bdsk-Url-1 = {http://dx.doi.org/10.1038/nchembio.117}}
Downloads: 0
{"_id":"MCJsToK47QWHdD6rv","bibbaseid":"apsel-blair-gonzalez-nazif-feldman-aizenstein-hoffman-williams-etal-targetedpolypharmacologydiscoveryofdualinhibitorsoftyrosineandphosphoinositidekinases-2008","downloads":0,"creationDate":"2016-02-18T13:03:30.220Z","title":"Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases","author_short":["Apsel, B.","Blair, J.","Gonzalez, B.","Nazif, T.","Feldman, M.","Aizenstein, B.","Hoffman, R.","Williams, R.","Shokat, K.","Knight, Z."],"year":2008,"bibtype":"article","biburl":"https://dl.dropboxusercontent.com/u/26998770/main.bib","bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Apsel"],"firstnames":["Beth"],"suffixes":[]},{"propositions":[],"lastnames":["Blair"],"firstnames":["Jimmy"],"suffixes":[]},{"propositions":[],"lastnames":["Gonzalez"],"firstnames":["Beatriz"],"suffixes":[]},{"propositions":[],"lastnames":["Nazif"],"firstnames":["Tamim"],"suffixes":[]},{"propositions":[],"lastnames":["Feldman"],"firstnames":["Morri"],"suffixes":[]},{"propositions":[],"lastnames":["Aizenstein"],"firstnames":["Brian"],"suffixes":[]},{"propositions":[],"lastnames":["Hoffman"],"firstnames":["Randy"],"suffixes":[]},{"propositions":[],"lastnames":["Williams"],"firstnames":["Roger"],"suffixes":[]},{"propositions":[],"lastnames":["Shokat"],"firstnames":["Kevan"],"suffixes":[]},{"propositions":[],"lastnames":["Knight"],"firstnames":["Zachary"],"suffixes":[]}],"date-added":"2009-07-26 20:27:25 -0400","date-modified":"2009-07-26 20:27:25 -0400","id":"Apsel:2008dn","journal":"Nat.~Chem.~Biol.","keywords":"kinase; polypharmacology","l3":"citeulike-article-id:3578400","month":"11","number":"11","pages":"691--699","publisher":"Nature Publishing Group","title":"Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases","ty":"JOUR","url":"http://dx.doi.org/10.1038/nchembio.117","volume":"4","year":"2008","bdsk-file-1":"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","bdsk-url-1":"http://dx.doi.org/10.1038/nchembio.117","bibtex":"@article{Apsel:2008dn,\n\tAuthor = {Apsel, Beth and Blair, Jimmy and Gonzalez, Beatriz and Nazif, Tamim and Feldman, Morri and Aizenstein, Brian and Hoffman, Randy and Williams, Roger and Shokat, Kevan and Knight, Zachary},\n\tDate-Added = {2009-07-26 20:27:25 -0400},\n\tDate-Modified = {2009-07-26 20:27:25 -0400},\n\tId = {citeulike:3578400},\n\tJournal = {Nat.~Chem.~Biol.},\n\tKeywords = {kinase; polypharmacology},\n\tL3 = {citeulike-article-id:3578400},\n\tMonth = {11},\n\tNumber = {11},\n\tPages = {691--699},\n\tPublisher = {Nature Publishing Group},\n\tTitle = {Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases},\n\tTy = {JOUR},\n\tUrl = {http://dx.doi.org/10.1038/nchembio.117},\n\tVolume = {4},\n\tYear = {2008},\n\tBdsk-File-1 = {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},\n\tBdsk-Url-1 = {http://dx.doi.org/10.1038/nchembio.117}}\n\n","author_short":["Apsel, B.","Blair, J.","Gonzalez, B.","Nazif, T.","Feldman, M.","Aizenstein, B.","Hoffman, R.","Williams, R.","Shokat, K.","Knight, Z."],"key":"Apsel:2008dn","bibbaseid":"apsel-blair-gonzalez-nazif-feldman-aizenstein-hoffman-williams-etal-targetedpolypharmacologydiscoveryofdualinhibitorsoftyrosineandphosphoinositidekinases-2008","role":"author","urls":{"Paper":"http://dx.doi.org/10.1038/nchembio.117"},"keyword":["kinase; polypharmacology"],"downloads":0},"search_terms":["targeted","polypharmacology","discovery","dual","inhibitors","tyrosine","phosphoinositide","kinases","apsel","blair","gonzalez","nazif","feldman","aizenstein","hoffman","williams","shokat","knight"],"keywords":["kinase; polypharmacology"],"authorIDs":[],"dataSources":["c5japf9eAQRaeMS4h"]}