Sequence Effects of Single Base Loops in Intramolecular Quadruplex DNA. a Rachwal, P., Brown, T., & Fox, K. R FEBS letters, 581(8):1657–60, May, 2007.
doi  abstract   bibtex   
We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1',2'-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2 degrees C). Quadruplexes containing loops with single A residues were less stable by 8 degrees C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel stranded complexes with double-chain reversal loops. These results demonstrate that loop sequence, and not just length, affects quadruplex stability.
@article{Rachwal2007,
  title = {Sequence Effects of Single Base Loops in Intramolecular Quadruplex {{DNA}}.},
  author = {a Rachwal, Phillip and Brown, Tom and Fox, Keith R},
  year = {2007},
  month = may,
  journal = {FEBS letters},
  volume = {581},
  number = {8},
  eprint = {17399710},
  eprinttype = {pubmed},
  pages = {1657--60},
  issn = {0014-5793},
  doi = {10.1016/j.febslet.2007.03.040},
  abstract = {We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1',2'-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2 degrees C). Quadruplexes containing loops with single A residues were less stable by 8 degrees C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel stranded complexes with double-chain reversal loops. These results demonstrate that loop sequence, and not just length, affects quadruplex stability.},
  pmid = {17399710},
  keywords = {\#nosource,Base Sequence,Deoxyribose,Deoxyribose: analysis,DNA,DNA: chemistry,DNA: genetics,G-Quadruplexes,Nucleic Acid Conformation,Oligonucleotides,Oligonucleotides: chemistry,Oligonucleotides: genetics,Thermodynamics}
}

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