@ARTICLE{Archakov20138,
author={Archakov, A.I. and Zgoda, V.G. and Kopylov, A.T. and Naryzhny, S.N. and Chernobrovkin, A.L. and Ponomarenko, E.A. and Lisitsa, A.V.},
title={Chromosomocentric approach to overcoming difficulties in implementation of international project Human Proteome},
journal={Ukrain'skyi Biokhimichnyi Zhurnal},
year={2013},
volume={85},
number={6},
pages={8-17},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84890366739&partnerID=40&md5=bcbec90a6d222127b50b7e4336c61146},
affiliation={V. N. Orekhovich Scientific-Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Russian Federation; Petersburg Nuclear Physics Institute at National Research Centre, Kurchatov Institute, Russian Federation},
abstract={The international project Human Proteome (PHP), being a logical continuation of the project Human Genome, was started on September 23, 2010. In correspondence with the genocentric approach, the PHP aim is to prepare a catalogue of all human proteins and to decipher a network of their interactions. The PHP implementation difficulties arise because the research subject itself -proteome -is much more complicated than genome. The major problem is the insufficient sensitivity of proteome methods that does not allow detecting low-and ultralow-copy proteins. Bad reproducibility of proteome methods and the lack of so-called gold standard is the second major complicacy in PHP implementation. The third problem is the dynamic character of proteome, its instability in time. The paper deals with possible variants of overcoming these complicacies, preventing from successful implementation of PHP.},
author_keywords={Massspectrometric method of monitoring of multiple responses;  Project Human Genome;  Project Human Proteome;  Sensitivity limit},
correspondence_address1={V. N. Orekhovich Scientific-Research Institute of Biomedical Chemistry, Russian Academy of Medical SciencesRussian Federation},
issn={02018470},
language={Ukrainian},
abbrev_source_title={Ukr. Biokhim. Zh.},
document_type={Article},
source={Scopus},
}

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