Letter Case and Text Legibility in Normal and Low Vision. Arditi, A. & Cho, J. Vision research, 47(19):2499–2505, September, 2007.
Letter Case and Text Legibility in Normal and Low Vision [link]Paper  doi  abstract   bibtex   
It is thought by cognitive scientists and typographers alike, that lower-case text is more legible than upper-case. Yet lower-case letters are, on average, smaller in height and width than upper-case characters, which suggests an upper-case advantage. Using a single unaltered font and all upper-, all lower-, and mixed-case text, we assessed size thresholds for words and random strings, and reading speeds for text with normal and visually impaired participants. Lower-case thresholds were roughly 0.1 log unit higher than upper-. Reading speeds were higher for upper- than for mixed-case text at sizes twice acuity size; at larger sizes, the upper-case advantage disappeared. Results suggest that upper-case is more legible than the other case styles, especially for visually-impaired readers, because smaller letter sizes can be used than with the other case styles, with no diminution of legibility.
@article{arditi_letter_2007,
	title = {Letter {Case} and {Text} {Legibility} in {Normal} and {Low} {Vision}},
	volume = {47},
	issn = {0042-6989},
	url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2016788/},
	doi = {10.1016/j.visres.2007.06.010},
	abstract = {It is thought by cognitive scientists and typographers alike, that lower-case text is more legible than upper-case. Yet lower-case letters are, on average, smaller in height and width than upper-case characters, which suggests an upper-case advantage. Using a single unaltered font and all upper-, all lower-, and mixed-case text, we assessed size thresholds for words and random strings, and reading speeds for text with normal and visually impaired participants. Lower-case thresholds were roughly 0.1 log unit higher than upper-. Reading speeds were higher for upper- than for mixed-case text at sizes twice acuity size; at larger sizes, the upper-case advantage disappeared. Results suggest that upper-case is more legible than the other case styles, especially for visually-impaired readers, because smaller letter sizes can be used than with the other case styles, with no diminution of legibility.},
	number = {19},
	urldate = {2019-04-05},
	journal = {Vision research},
	author = {Arditi, Aries and Cho, Jianna},
	month = sep,
	year = {2007},
	pmid = {17675131},
	pmcid = {PMC2016788},
	pages = {2499--2505}
}

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