@article{RN225,
   author = {Arena, C. B. and Sano, M. B. and Rylander, M. N. and Davalos, R. V.},
   title = {Theoretical considerations of tissue electroporation with high-frequency bipolar pulses},
   journal = {IEEE Trans Biomed Eng},
   volume = {58},
   number = {5},
   pages = {1474-82},
   note = {1558-2531
Arena, Christopher B
Sano, Michael B
Rylander, Marissa Nichole
Davalos, Rafael V
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
United States
2010/12/30
IEEE Trans Biomed Eng. 2011 May;58(5):1474-82. doi: 10.1109/TBME.2010.2102021. Epub 2010 Dec 23.},
   abstract = {This study introduces the use of high-frequency pulsed electric fields for tissue electroporation. Through the development of finite element models and the use of analytical techniques, electroporation with rectangular, bipolar pulses is investigated. The electric field and temperature distribution along with the associated transmembrane potential development are considered in a heterogeneous skin fold geometry. Results indicate that switching polarity on the nanosecond scale near the charging time of plasma membranes can greatly improve treatment outcomes in heterogeneous tissues. Specifically, high-frequency fields ranging from 500 kHz to 1 MHz are best suited to penetrate epithelial layers without inducing significant Joule heating, and cause electroporation in underlying cells.},
   keywords = {*Electroporation
Epidermis
Finite Element Analysis
Humans
*Membrane Potentials
*Models, Biological
Skin Physiological Phenomena
Temperature},
   ISSN = {0018-9294},
   DOI = {10.1109/tbme.2010.2102021},
   year = {2011},
   type = {Journal Article}
}

{"_id":"X5m3hcz8CKp8vutMF","bibbaseid":"arena-sano-rylander-davalos-theoreticalconsiderationsoftissueelectroporationwithhighfrequencybipolarpulses-2011","author_short":["Arena, C. B.","Sano, M. B.","Rylander, M. N.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Arena"],"firstnames":["C.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Sano"],"firstnames":["M.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Rylander"],"firstnames":["M.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Theoretical considerations of tissue electroporation with high-frequency bipolar pulses","journal":"IEEE Trans Biomed Eng","volume":"58","number":"5","pages":"1474-82","note":"1558-2531 Arena, Christopher B Sano, Michael B Rylander, Marissa Nichole Davalos, Rafael V Journal Article Research Support, U.S. Gov't, Non-P.H.S. United States 2010/12/30 IEEE Trans Biomed Eng. 2011 May;58(5):1474-82. doi: 10.1109/TBME.2010.2102021. Epub 2010 Dec 23.","abstract":"This study introduces the use of high-frequency pulsed electric fields for tissue electroporation. Through the development of finite element models and the use of analytical techniques, electroporation with rectangular, bipolar pulses is investigated. The electric field and temperature distribution along with the associated transmembrane potential development are considered in a heterogeneous skin fold geometry. Results indicate that switching polarity on the nanosecond scale near the charging time of plasma membranes can greatly improve treatment outcomes in heterogeneous tissues. Specifically, high-frequency fields ranging from 500 kHz to 1 MHz are best suited to penetrate epithelial layers without inducing significant Joule heating, and cause electroporation in underlying cells.","keywords":"*Electroporation Epidermis Finite Element Analysis Humans *Membrane Potentials *Models, Biological Skin Physiological Phenomena Temperature","issn":"0018-9294","doi":"10.1109/tbme.2010.2102021","year":"2011","bibtex":"@article{RN225,\n author = {Arena, C. B. and Sano, M. B. and Rylander, M. N. and Davalos, R. V.},\n title = {Theoretical considerations of tissue electroporation with high-frequency bipolar pulses},\n journal = {IEEE Trans Biomed Eng},\n volume = {58},\n number = {5},\n pages = {1474-82},\n note = {1558-2531\nArena, Christopher B\nSano, Michael B\nRylander, Marissa Nichole\nDavalos, Rafael V\nJournal Article\nResearch Support, U.S. Gov't, Non-P.H.S.\nUnited States\n2010/12/30\nIEEE Trans Biomed Eng. 2011 May;58(5):1474-82. doi: 10.1109/TBME.2010.2102021. Epub 2010 Dec 23.},\n abstract = {This study introduces the use of high-frequency pulsed electric fields for tissue electroporation. Through the development of finite element models and the use of analytical techniques, electroporation with rectangular, bipolar pulses is investigated. The electric field and temperature distribution along with the associated transmembrane potential development are considered in a heterogeneous skin fold geometry. Results indicate that switching polarity on the nanosecond scale near the charging time of plasma membranes can greatly improve treatment outcomes in heterogeneous tissues. Specifically, high-frequency fields ranging from 500 kHz to 1 MHz are best suited to penetrate epithelial layers without inducing significant Joule heating, and cause electroporation in underlying cells.},\n keywords = {*Electroporation\nEpidermis\nFinite Element Analysis\nHumans\n*Membrane Potentials\n*Models, Biological\nSkin Physiological Phenomena\nTemperature},\n ISSN = {0018-9294},\n DOI = {10.1109/tbme.2010.2102021},\n year = {2011},\n type = {Journal Article}\n}\n\n","author_short":["Arena, C. B.","Sano, M. B.","Rylander, M. N.","Davalos, R. V."],"key":"RN225","id":"RN225","bibbaseid":"arena-sano-rylander-davalos-theoreticalconsiderationsoftissueelectroporationwithhighfrequencybipolarpulses-2011","role":"author","urls":{},"keyword":["*Electroporation Epidermis Finite Element Analysis Humans *Membrane Potentials *Models","Biological Skin Physiological Phenomena Temperature"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["jyPDX94q4eN77sJMM","FNmMRi7tdYbCtyXGW","D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["*electroporation epidermis finite element analysis humans *membrane potentials *models","biological skin physiological phenomena temperature"],"search_terms":["theoretical","considerations","tissue","electroporation","high","frequency","bipolar","pulses","arena","sano","rylander","davalos"],"title":"Theoretical considerations of tissue electroporation with high-frequency bipolar pulses","year":2011}