Mechanical Unfolding of Long Human Telomeric RNA (TERRA). Arias-Gonzalez, J. R., Garavís, Miguel, Bocanegra, R., Herrero-Galán, E., Villasante, A., Gonzalez, C., & González, C. Chemical communications (Cambridge, England), 49(57):6397–6399, June, 2013. doi abstract bibtex We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order structures comprised of single parallel G-quadruplex blocks, which unfold at lower forces than their DNA counterparts.
@article{arias-gonzalezMechanicalUnfoldingLong2013,
ids = {garavisMechanicalUnfoldingLong2013,garavisMechanicalUnfoldingLong2013a},
title = {Mechanical Unfolding of Long Human Telomeric {{RNA}} ({{TERRA}}).},
author = {{Arias-Gonzalez}, J. Ricardo and Garav{\'i}s, Miguel and Bocanegra, Rebeca and {Herrero-Gal{\'a}n}, El{\'i}as and Villasante, Alfredo and Gonzalez, Carlos and Gonz{\'a}lez, Carlos},
year = {2013},
month = jun,
journal = {Chemical communications (Cambridge, England)},
volume = {49},
number = {57},
pages = {6397--6399},
issn = {1364-548X},
doi = {10.1039/c3cc42981d},
abstract = {We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order structures comprised of single parallel G-quadruplex blocks, which unfold at lower forces than their DNA counterparts.},
pmid = {23748212},
file = {E:\UBCloud\Zotero\storage\5M2JRF7I\Garavís et al. - 2013 - Mechanical unfolding of long human telomeric RNA (.pdf}
}
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