Rotavirus Vaccine Take in Infants Is Associated With Secretor Status. Armah, G. E., Cortese, M. M., Dennis, F. E., Yu, Y., Morrow, A. L., McNeal, M. M., Lewis, K. D. C., Awuni, D. A., Armachie, J., & Parashar, U. D. The Journal of Infectious Diseases, October, 2018.
doi  abstract   bibtex   
Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.
@article{armah_rotavirus_2018,
	title = {Rotavirus {Vaccine} {Take} in {Infants} {Is} {Associated} {With} {Secretor} {Status}},
	issn = {1537-6613},
	doi = {10.1093/infdis/jiy573},
	abstract = {Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41\% seroconversion for secretors vs 13\% for nonsecretors; relative risk, 3.2 (95\% confidence interval, 1.2-8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.},
	language = {eng},
	journal = {The Journal of Infectious Diseases},
	author = {Armah, George E. and Cortese, Margaret M. and Dennis, Francis E. and Yu, Ying and Morrow, Ardythe L. and McNeal, Monica M. and Lewis, Kristen D. C. and Awuni, Denis A. and Armachie, Joseph and Parashar, Umesh D.},
	month = oct,
	year = {2018},
	pmid = {30357332},
}

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