@article{arnone_role_2018,
	title = {Role of {Kynurenine} pathway and its metabolites in mood disorders: {A} systematic review and meta-analysis of clinical studies},
	volume = {92},
	issn = {1873-7528},
	shorttitle = {Role of {Kynurenine} pathway and its metabolites in mood disorders},
	doi = {10.1016/j.neubiorev.2018.05.031},
	abstract = {Activation of the kynurenine pathway is one of the described mechanisms by which inflammation can induce depression. It involves multiple pathways including interference with the bioavailability of tryptophan central to the synthesis of the neurotransmitter serotonin. In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ratio of kynurenine and tryptophan) and mood disorders by conducting a meta-analysis. Fifty-six studies were identified, 21 met inclusion criteria and 14 were deemed suitable (9 investigating unipolar depression and 5 bipolar disorder). We found decreased levels of kynurenine in unipolar major depression vs. healthy controls but studies were significantly heterogeneous in nature. No significant differences were found in tryptophan levels or kynurenine/tryptophan ratios. Kynurenine metabolites are likely to play a role in major depression but an exact etiological role in mood disorder seem complex and requires further research.},
	language = {eng},
	journal = {Neuroscience and Biobehavioral Reviews},
	author = {Arnone, Danilo and Saraykar, Smita and Salem, Haitham and Teixeira, Antonio L. and Dantzer, Robert and Selvaraj, Sudhakar},
	year = {2018},
	pmid = {29940237},
	pmcid = {PMC6686193},
	keywords = {Bipolar disorder, Depression, Humans, Inflammation, Kynurenic Acid, Kynurenine, Mood Disorders, Mood disorder, Quinolinic Acid, Quinolinic acid, Serotonin, Signal Transduction, Tryptophan},
	pages = {477--485},
}

{"_id":"GwJXu4idagf8iCicb","bibbaseid":"arnone-saraykar-salem-teixeira-dantzer-selvaraj-roleofkynureninepathwayanditsmetabolitesinmooddisordersasystematicreviewandmetaanalysisofclinicalstudies-2018","author_short":["Arnone, D.","Saraykar, S.","Salem, H.","Teixeira, A. L.","Dantzer, R.","Selvaraj, S."],"bibdata":{"bibtype":"article","type":"article","title":"Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies","volume":"92","issn":"1873-7528","shorttitle":"Role of Kynurenine pathway and its metabolites in mood disorders","doi":"10.1016/j.neubiorev.2018.05.031","abstract":"Activation of the kynurenine pathway is one of the described mechanisms by which inflammation can induce depression. It involves multiple pathways including interference with the bioavailability of tryptophan central to the synthesis of the neurotransmitter serotonin. In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ratio of kynurenine and tryptophan) and mood disorders by conducting a meta-analysis. Fifty-six studies were identified, 21 met inclusion criteria and 14 were deemed suitable (9 investigating unipolar depression and 5 bipolar disorder). We found decreased levels of kynurenine in unipolar major depression vs. healthy controls but studies were significantly heterogeneous in nature. No significant differences were found in tryptophan levels or kynurenine/tryptophan ratios. Kynurenine metabolites are likely to play a role in major depression but an exact etiological role in mood disorder seem complex and requires further research.","language":"eng","journal":"Neuroscience and Biobehavioral Reviews","author":[{"propositions":[],"lastnames":["Arnone"],"firstnames":["Danilo"],"suffixes":[]},{"propositions":[],"lastnames":["Saraykar"],"firstnames":["Smita"],"suffixes":[]},{"propositions":[],"lastnames":["Salem"],"firstnames":["Haitham"],"suffixes":[]},{"propositions":[],"lastnames":["Teixeira"],"firstnames":["Antonio","L."],"suffixes":[]},{"propositions":[],"lastnames":["Dantzer"],"firstnames":["Robert"],"suffixes":[]},{"propositions":[],"lastnames":["Selvaraj"],"firstnames":["Sudhakar"],"suffixes":[]}],"year":"2018","pmid":"29940237","pmcid":"PMC6686193","keywords":"Bipolar disorder, Depression, Humans, Inflammation, Kynurenic Acid, Kynurenine, Mood Disorders, Mood disorder, Quinolinic Acid, Quinolinic acid, Serotonin, Signal Transduction, Tryptophan","pages":"477–485","bibtex":"@article{arnone_role_2018,\n\ttitle = {Role of {Kynurenine} pathway and its metabolites in mood disorders: {A} systematic review and meta-analysis of clinical studies},\n\tvolume = {92},\n\tissn = {1873-7528},\n\tshorttitle = {Role of {Kynurenine} pathway and its metabolites in mood disorders},\n\tdoi = {10.1016/j.neubiorev.2018.05.031},\n\tabstract = {Activation of the kynurenine pathway is one of the described mechanisms by which inflammation can induce depression. It involves multiple pathways including interference with the bioavailability of tryptophan central to the synthesis of the neurotransmitter serotonin. In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ratio of kynurenine and tryptophan) and mood disorders by conducting a meta-analysis. Fifty-six studies were identified, 21 met inclusion criteria and 14 were deemed suitable (9 investigating unipolar depression and 5 bipolar disorder). We found decreased levels of kynurenine in unipolar major depression vs. healthy controls but studies were significantly heterogeneous in nature. No significant differences were found in tryptophan levels or kynurenine/tryptophan ratios. Kynurenine metabolites are likely to play a role in major depression but an exact etiological role in mood disorder seem complex and requires further research.},\n\tlanguage = {eng},\n\tjournal = {Neuroscience and Biobehavioral Reviews},\n\tauthor = {Arnone, Danilo and Saraykar, Smita and Salem, Haitham and Teixeira, Antonio L. and Dantzer, Robert and Selvaraj, Sudhakar},\n\tyear = {2018},\n\tpmid = {29940237},\n\tpmcid = {PMC6686193},\n\tkeywords = {Bipolar disorder, Depression, Humans, Inflammation, Kynurenic Acid, Kynurenine, Mood Disorders, Mood disorder, Quinolinic Acid, Quinolinic acid, Serotonin, Signal Transduction, Tryptophan},\n\tpages = {477--485},\n}\n\n","author_short":["Arnone, D.","Saraykar, S.","Salem, H.","Teixeira, A. 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