@article{arora_risk_2009,
	series = {Special issue: {Colonoscopy} for colorectal neoplasia},
	title = {Risk of perforation from a colonoscopy in adults: a large population-based study},
	volume = {69},
	issn = {0016-5107},
	shorttitle = {Risk of perforation from a colonoscopy in adults},
	url = {https://www.sciencedirect.com/science/article/pii/S0016510708025911},
	doi = {10/d2dc4n},
	abstract = {Background
Previous studies that reported the incidence of perforation from a colonoscopy are limited by small sample sizes, restricted age groups, or single-center data.
Objective
To determine the incidence and risk factors of colonic perforation from a colonoscopy in a large population cohort.
Design
Retrospective, population-based, cohort study, followed by a nested case-control study.
Setting
California Medicaid program claims database.
Patients
A total of 277,434 patients (aged 18 years and older) who underwent a colonoscopy during 1995 to 2005, age, sex, and time matched to 4 unique general-population controls.
Main Outcome Measurements
Perforation incidence in the 7 days after colonoscopy (or matched index date for controls) with odds ratio (OR); multivariate logistic regression to calculate adjusted ORs for subsequent analysis of risk factors.
Results
A total of 228 perforations were diagnosed after 277,434 colonoscopies, which corresponded to a cumulative 7-day incidence of 0.082\%. The OR of getting a perforation from a colonoscopy compared with matched controls (n = 1,072,723) who did not undergo a colonoscopy was 27.6 (95\% CI, 19.04-39.92), P {\textless} .001. On multivariate analysis, when comparing the group that had a perforation after a colonoscopy (n = 216) with those who did not (n = 269,496), increasing age, significant comorbidity, obstruction as an indication for the colonoscopy, and performance of invasive interventions during colonoscopy were significant positive predictors. Performance of biopsy or polypectomy did not affect the perforation risk. The rate of perforation did not change significantly over time.
Limitations
Validity of coding and capturing of all perforation diagnoses may possibly be deficient.
Conclusion
The risk of perforation from a colonoscopy is low, but, despite increased experience with the procedure, it remains unchanged over time.},
	language = {en},
	number = {3, Part 2},
	urldate = {2021-10-21},
	journal = {Gastrointestinal Endoscopy},
	author = {Arora, Gaurav and Mannalithara, Ajitha and Singh, Gurkirpal and Gerson, Lauren B. and Triadafilopoulos, George},
	month = mar,
	year = {2009},
	note = {ZSCC: 0000299},
	keywords = {Unread},
	pages = {654--664},
}

{"_id":"6cKwCzFAChkKrwRYZ","bibbaseid":"arora-mannalithara-singh-gerson-triadafilopoulos-riskofperforationfromacolonoscopyinadultsalargepopulationbasedstudy-2009","author_short":["Arora, G.","Mannalithara, A.","Singh, G.","Gerson, L. B.","Triadafilopoulos, G."],"bibdata":{"bibtype":"article","type":"article","series":"Special issue: Colonoscopy for colorectal neoplasia","title":"Risk of perforation from a colonoscopy in adults: a large population-based study","volume":"69","issn":"0016-5107","shorttitle":"Risk of perforation from a colonoscopy in adults","url":"https://www.sciencedirect.com/science/article/pii/S0016510708025911","doi":"10/d2dc4n","abstract":"Background Previous studies that reported the incidence of perforation from a colonoscopy are limited by small sample sizes, restricted age groups, or single-center data. Objective To determine the incidence and risk factors of colonic perforation from a colonoscopy in a large population cohort. Design Retrospective, population-based, cohort study, followed by a nested case-control study. Setting California Medicaid program claims database. Patients A total of 277,434 patients (aged 18 years and older) who underwent a colonoscopy during 1995 to 2005, age, sex, and time matched to 4 unique general-population controls. Main Outcome Measurements Perforation incidence in the 7 days after colonoscopy (or matched index date for controls) with odds ratio (OR); multivariate logistic regression to calculate adjusted ORs for subsequent analysis of risk factors. Results A total of 228 perforations were diagnosed after 277,434 colonoscopies, which corresponded to a cumulative 7-day incidence of 0.082%. The OR of getting a perforation from a colonoscopy compared with matched controls (n = 1,072,723) who did not undergo a colonoscopy was 27.6 (95% CI, 19.04-39.92), P \\textless .001. On multivariate analysis, when comparing the group that had a perforation after a colonoscopy (n = 216) with those who did not (n = 269,496), increasing age, significant comorbidity, obstruction as an indication for the colonoscopy, and performance of invasive interventions during colonoscopy were significant positive predictors. Performance of biopsy or polypectomy did not affect the perforation risk. The rate of perforation did not change significantly over time. Limitations Validity of coding and capturing of all perforation diagnoses may possibly be deficient. Conclusion The risk of perforation from a colonoscopy is low, but, despite increased experience with the procedure, it remains unchanged over time.","language":"en","number":"3, Part 2","urldate":"2021-10-21","journal":"Gastrointestinal Endoscopy","author":[{"propositions":[],"lastnames":["Arora"],"firstnames":["Gaurav"],"suffixes":[]},{"propositions":[],"lastnames":["Mannalithara"],"firstnames":["Ajitha"],"suffixes":[]},{"propositions":[],"lastnames":["Singh"],"firstnames":["Gurkirpal"],"suffixes":[]},{"propositions":[],"lastnames":["Gerson"],"firstnames":["Lauren","B."],"suffixes":[]},{"propositions":[],"lastnames":["Triadafilopoulos"],"firstnames":["George"],"suffixes":[]}],"month":"March","year":"2009","note":"ZSCC: 0000299","keywords":"Unread","pages":"654–664","bibtex":"@article{arora_risk_2009,\n\tseries = {Special issue: {Colonoscopy} for colorectal neoplasia},\n\ttitle = {Risk of perforation from a colonoscopy in adults: a large population-based study},\n\tvolume = {69},\n\tissn = {0016-5107},\n\tshorttitle = {Risk of perforation from a colonoscopy in adults},\n\turl = {https://www.sciencedirect.com/science/article/pii/S0016510708025911},\n\tdoi = {10/d2dc4n},\n\tabstract = {Background\nPrevious studies that reported the incidence of perforation from a colonoscopy are limited by small sample sizes, restricted age groups, or single-center data.\nObjective\nTo determine the incidence and risk factors of colonic perforation from a colonoscopy in a large population cohort.\nDesign\nRetrospective, population-based, cohort study, followed by a nested case-control study.\nSetting\nCalifornia Medicaid program claims database.\nPatients\nA total of 277,434 patients (aged 18 years and older) who underwent a colonoscopy during 1995 to 2005, age, sex, and time matched to 4 unique general-population controls.\nMain Outcome Measurements\nPerforation incidence in the 7 days after colonoscopy (or matched index date for controls) with odds ratio (OR); multivariate logistic regression to calculate adjusted ORs for subsequent analysis of risk factors.\nResults\nA total of 228 perforations were diagnosed after 277,434 colonoscopies, which corresponded to a cumulative 7-day incidence of 0.082\\%. The OR of getting a perforation from a colonoscopy compared with matched controls (n = 1,072,723) who did not undergo a colonoscopy was 27.6 (95\\% CI, 19.04-39.92), P {\\textless} .001. On multivariate analysis, when comparing the group that had a perforation after a colonoscopy (n = 216) with those who did not (n = 269,496), increasing age, significant comorbidity, obstruction as an indication for the colonoscopy, and performance of invasive interventions during colonoscopy were significant positive predictors. Performance of biopsy or polypectomy did not affect the perforation risk. The rate of perforation did not change significantly over time.\nLimitations\nValidity of coding and capturing of all perforation diagnoses may possibly be deficient.\nConclusion\nThe risk of perforation from a colonoscopy is low, but, despite increased experience with the procedure, it remains unchanged over time.},\n\tlanguage = {en},\n\tnumber = {3, Part 2},\n\turldate = {2021-10-21},\n\tjournal = {Gastrointestinal Endoscopy},\n\tauthor = {Arora, Gaurav and Mannalithara, Ajitha and Singh, Gurkirpal and Gerson, Lauren B. and Triadafilopoulos, George},\n\tmonth = mar,\n\tyear = {2009},\n\tnote = {ZSCC: 0000299},\n\tkeywords = {Unread},\n\tpages = {654--664},\n}\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n","author_short":["Arora, G.","Mannalithara, A.","Singh, G.","Gerson, L. B.","Triadafilopoulos, G."],"key":"arora_risk_2009","id":"arora_risk_2009","bibbaseid":"arora-mannalithara-singh-gerson-triadafilopoulos-riskofperforationfromacolonoscopyinadultsalargepopulationbasedstudy-2009","role":"author","urls":{"Paper":"https://www.sciencedirect.com/science/article/pii/S0016510708025911"},"keyword":["Unread"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/nikitaj.greenidge","dataSources":["uXDRqZDxuAtbLLS2T"],"keywords":["unread"],"search_terms":["risk","perforation","colonoscopy","adults","large","population","based","study","arora","mannalithara","singh","gerson","triadafilopoulos"],"title":"Risk of perforation from a colonoscopy in adults: a large population-based study","year":2009}