An LRR receptor kinase controls ABC transporter substrate preferences during plant growth-defense decisions. Aryal, B., Xia, J., Hu, Z., Stumpe, M., Tsering, T., Liu, J., Huynh, J., Fukao, Y., Glöckner, N., Huang, H., Sáncho-Andrés, G., Pakula, K., Ziegler, J., Gorzolka, K., Zwiewka, M., Nodzynski, T., Harter, K., Sánchez-Rodríguez, C., Jasiński, M., Rosahl, S., & Geisler, M. M. Current Biology, 33(10):2008–2023.e8, May, 2023.
An LRR receptor kinase controls ABC transporter substrate preferences during plant growth-defense decisions [link]Paper  doi  abstract   bibtex   
The exporter of the auxin precursor indole-3-butyric acid (IBA), ABCG36/PDR8/PEN3, from the model plant Arabidopsis has recently been proposed to also function in the transport of the phytoalexin camalexin. Based on these bonafide substrates, it has been suggested that ABCG36 functions at the interface between growth and defense. Here, we provide evidence that ABCG36 catalyzes the direct, ATP-dependent export of camalexin across the plasma membrane. We identify the leucine-rich repeat receptor kinase, QIAN SHOU KINASE1 (QSK1), as a functional kinase that physically interacts with and phosphorylates ABCG36. Phosphorylation of ABCG36 by QSK1 unilaterally represses IBA export, allowing camalexin export by ABCG36 conferring pathogen resistance. As a consequence, phospho-dead mutants of ABCG36, as well as qsk1 and abcg36 alleles, are hypersensitive to infection with the root pathogen Fusarium oxysporum, caused by elevated fungal progression. Our findings indicate a direct regulatory circuit between a receptor kinase and an ABC transporter that functions to control transporter substrate preference during plant growth and defense balance decisions.
@article{aryal_lrr_2023,
	title = {An {LRR} receptor kinase controls {ABC} transporter substrate preferences during plant growth-defense decisions},
	volume = {33},
	issn = {0960-9822},
	url = {https://www.cell.com/current-biology/abstract/S0960-9822(23)00477-3},
	doi = {10.1016/j.cub.2023.04.029},
	abstract = {The exporter of the auxin precursor indole-3-butyric acid (IBA), ABCG36/PDR8/PEN3, from the model plant Arabidopsis has recently been proposed to also function in the transport of the phytoalexin camalexin. Based on these bonafide substrates, it has been suggested that ABCG36 functions at the interface between growth and defense.
Here, we provide evidence that ABCG36 catalyzes the direct, ATP-dependent export of camalexin across the plasma membrane. We identify the leucine-rich repeat receptor kinase, QIAN SHOU KINASE1 (QSK1), as a functional kinase that physically interacts with and phosphorylates ABCG36. Phosphorylation of ABCG36 by QSK1 unilaterally represses IBA export, allowing camalexin export by ABCG36 conferring pathogen resistance. As a consequence, phospho-dead mutants of ABCG36, as well as qsk1 and abcg36 alleles, are hypersensitive to infection with the root pathogen Fusarium oxysporum, caused by elevated fungal progression.
Our findings indicate a direct regulatory circuit between a receptor kinase and an ABC transporter that functions to control transporter substrate preference during plant growth and defense balance decisions.},
	language = {English},
	number = {10},
	urldate = {2023-05-24},
	journal = {Current Biology},
	author = {Aryal, Bibek and Xia, Jian and Hu, Zehan and Stumpe, Michael and Tsering, Tashi and Liu, Jie and Huynh, John and Fukao, Yoichiro and Glöckner, Nina and Huang, Hsin-Yao and Sáncho-Andrés, Gloria and Pakula, Konrad and Ziegler, Joerg and Gorzolka, Karin and Zwiewka, Marta and Nodzynski, Tomasz and Harter, Klaus and Sánchez-Rodríguez, Clara and Jasiński, Michał and Rosahl, Sabine and Geisler, Markus M.},
	month = may,
	year = {2023},
	keywords = {ABCG36, Arabidopsis thaliana, Botrytis cinerea, Fusarium oxysporum, IBA, PDR8, PEN3, Phytophtora infestans, QSK1, auxin, camalexin, defense, growth},
	pages = {2008--2023.e8},
}
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