Clinical phenotype of families with longevity. Atzmon, G., Schechter, C., Greiner, W., Davidson, D., Rennert, G., & Barzilai, N. J Am Geriatr Soc, 52(2):274-277, 2004.
![Clinical phenotype of families with longevity [pdf]](https://bibbase.org/img/filetypes/pdf.svg "pdf")
Paper ![Clinical phenotype of families with longevity [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex
Paper Website abstract bibtex OBJECTIVES: To determine whether offspring of centenarians acquired protection from age-related diseases. DESIGN: Case-control study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey. MEASUREMENTS: Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass. RESULTS: Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) "risk" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups. CONCLUSION: Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.
@article{
title = {Clinical phenotype of families with longevity},
type = {article},
year = {2004},
identifiers = {[object Object]},
keywords = {*Family Health,Aged,Aged, 80 and over,Cardiovascular Diseases/*epidemiology/genetics,Case-Control Studies,Chronic Disease/*epidemiology,European Continental Ancestry Group/statistics & n,Female,Humans,Israel/epidemiology,Jews/statistics & numerical data,Longevity/*genetics,Male,Matched-Pair Analysis,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.,Risk,Sex Factors,Statistics, Nonparametric,United States/epidemiology},
pages = {274-277},
volume = {52},
websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14728640},
id = {269afc28-8f71-3cb1-91c4-4f7293ce8166},
created = {2017-06-19T13:45:32.818Z},
file_attached = {true},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:45:32.918Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
source_type = {Journal Article},
notes = {<m:note>0002-8614<m:linebreak/>Journal Article</m:note>},
abstract = {OBJECTIVES: To determine whether offspring of centenarians acquired protection from age-related diseases. DESIGN: Case-control study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey. MEASUREMENTS: Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass. RESULTS: Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) "risk" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups. CONCLUSION: Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.},
bibtype = {article},
author = {Atzmon, G and Schechter, C and Greiner, W and Davidson, D and Rennert, G and Barzilai, N},
journal = {J Am Geriatr Soc},
number = {2}
}Downloads: 0
{"_id":"4jfPir6wntuY4mxME","bibbaseid":"atzmon-schechter-greiner-davidson-rennert-barzilai-clinicalphenotypeoffamilieswithlongevity-2004","downloads":0,"creationDate":"2017-06-19T14:46:34.918Z","title":"Clinical phenotype of families with longevity","author_short":["Atzmon, G.","Schechter, C.","Greiner, W.","Davidson, D.","Rennert, G.","Barzilai, N."],"year":2004,"bibtype":"article","biburl":null,"bibdata":{"title":"Clinical phenotype of families with longevity","type":"article","year":"2004","identifiers":"[object Object]","keywords":"*Family Health,Aged,Aged, 80 and over,Cardiovascular Diseases/*epidemiology/genetics,Case-Control Studies,Chronic Disease/*epidemiology,European Continental Ancestry Group/statistics & n,Female,Humans,Israel/epidemiology,Jews/statistics & numerical data,Longevity/*genetics,Male,Matched-Pair Analysis,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.,Risk,Sex Factors,Statistics, Nonparametric,United States/epidemiology","pages":"274-277","volume":"52","websites":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14728640","id":"269afc28-8f71-3cb1-91c4-4f7293ce8166","created":"2017-06-19T13:45:32.818Z","file_attached":"true","profile_id":"de68dde1-2ff3-3a4e-a214-ef424d0c7646","group_id":"b2078731-0913-33b9-8902-a53629a24e83","last_modified":"2017-06-19T13:45:32.918Z","read":false,"starred":false,"authored":false,"confirmed":"true","hidden":false,"source_type":"Journal Article","notes":"<m:note>0002-8614<m:linebreak/>Journal Article</m:note>","abstract":"OBJECTIVES: To determine whether offspring of centenarians acquired protection from age-related diseases. DESIGN: Case-control study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey. MEASUREMENTS: Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass. RESULTS: Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) \"risk\" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups. CONCLUSION: Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.","bibtype":"article","author":"Atzmon, G and Schechter, C and Greiner, W and Davidson, D and Rennert, G and Barzilai, N","journal":"J Am Geriatr Soc","number":"2","bibtex":"@article{\n title = {Clinical phenotype of families with longevity},\n type = {article},\n year = {2004},\n identifiers = {[object Object]},\n keywords = {*Family Health,Aged,Aged, 80 and over,Cardiovascular Diseases/*epidemiology/genetics,Case-Control Studies,Chronic Disease/*epidemiology,European Continental Ancestry Group/statistics & n,Female,Humans,Israel/epidemiology,Jews/statistics & numerical data,Longevity/*genetics,Male,Matched-Pair Analysis,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, P.H.S.,Risk,Sex Factors,Statistics, Nonparametric,United States/epidemiology},\n pages = {274-277},\n volume = {52},\n websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14728640},\n id = {269afc28-8f71-3cb1-91c4-4f7293ce8166},\n created = {2017-06-19T13:45:32.818Z},\n file_attached = {true},\n profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},\n group_id = {b2078731-0913-33b9-8902-a53629a24e83},\n last_modified = {2017-06-19T13:45:32.918Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n source_type = {Journal Article},\n notes = {<m:note>0002-8614<m:linebreak/>Journal Article</m:note>},\n abstract = {OBJECTIVES: To determine whether offspring of centenarians acquired protection from age-related diseases. DESIGN: Case-control study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey. MEASUREMENTS: Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass. RESULTS: Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) \"risk\" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups. CONCLUSION: Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.},\n bibtype = {article},\n author = {Atzmon, G and Schechter, C and Greiner, W and Davidson, D and Rennert, G and Barzilai, N},\n journal = {J Am Geriatr Soc},\n number = {2}\n}","author_short":["Atzmon, G.","Schechter, C.","Greiner, W.","Davidson, D.","Rennert, G.","Barzilai, N."],"urls":{"Paper":"http://bibbase.org/service/mendeley/de68dde1-2ff3-3a4e-a214-ef424d0c7646/file/7479fa50-3071-bd0f-1395-35a0c4191442/2004-Clinical_phenotype_of_families_with_longevity.pdf.pdf","Website":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14728640"},"bibbaseid":"atzmon-schechter-greiner-davidson-rennert-barzilai-clinicalphenotypeoffamilieswithlongevity-2004","role":"author","keyword":["*Family Health","Aged","Aged","80 and over","Cardiovascular Diseases/*epidemiology/genetics","Case-Control Studies","Chronic Disease/*epidemiology","European Continental Ancestry Group/statistics & n","Female","Humans","Israel/epidemiology","Jews/statistics & numerical data","Longevity/*genetics","Male","Matched-Pair Analysis","Middle Aged","Prevalence","Research Support","Non-U.S. Gov't","Research Support","U.S. Gov't","P.H.S.","Risk","Sex Factors","Statistics","Nonparametric","United States/epidemiology"],"downloads":0},"search_terms":["clinical","phenotype","families","longevity","atzmon","schechter","greiner","davidson","rennert","barzilai"],"keywords":["*family health","aged","aged","80 and over","cardiovascular diseases/*epidemiology/genetics","case-control studies","chronic disease/*epidemiology","european continental ancestry group/statistics & n","female","humans","israel/epidemiology","jews/statistics & numerical data","longevity/*genetics","male","matched-pair analysis","middle aged","prevalence","research support","non-u.s. gov't","research support","u.s. gov't","p.h.s.","risk","sex factors","statistics","nonparametric","united states/epidemiology"],"authorIDs":[]}