@article{RN109,
   author = {Aycock, K. N. and Vadlamani, R. A. and Jacobs, E. J. and Imran, K. M. and Verbridge, S. S. and Allen, I. C. and Manuchehrabadi, N. and Davalos, R. V.},
   title = {Experimental and Numerical Investigation of Parameters Affecting High-Frequency Irreversible Electroporation for Prostate Cancer Ablation},
   journal = {J Biomech Eng},
   volume = {144},
   number = {6},
   note = {1528-8951
Aycock, Kenneth N
Vadlamani, Ram Anand
Jacobs, Edward J
Imran, Khan Mohammad
Verbridge, Scott S
Allen, Irving C
Manuchehrabadi, Navid
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
United States
2022/01/20
J Biomech Eng. 2022 Jun 1;144(6):061003. doi: 10.1115/1.4053595.},
   abstract = {While the primary goal of focal therapy for prostate cancer (PCa) is conserving patient quality of life by reducing oncological burden, available modalities use thermal energy or whole-gland radiation which can damage critical neurovascular structures within the prostate and increase risk of genitourinary dysfunction. High-frequency irreversible electroporation (H-FIRE) is a promising alternative ablation modality that utilizes bursts of pulsed electric fields (PEFs) to destroy aberrant cells via targeted membrane damage. Due to its nonthermal mechanism, H-FIRE offers several advantages over state-of-the-art treatments, but waveforms have not been optimized for treatment of PCa. In this study, we characterize lethal electric field thresholds (EFTs) for H-FIRE waveforms with three different pulse widths as well as three interpulse delays in vitro and compare them to conventional irreversible electroporation (IRE). Experiments were performed in non-neoplastic and malignant prostate cells to determine the effect of waveforms on both targeted (malignant) and adjacent (non-neoplastic) tissue. A numerical modeling approach was developed to estimate the clinical effects of each waveform including extent of nonthermal ablation, undesired thermal damage, and nerve excitation. Our findings indicate that H-FIRE waveforms with pulse durations of 5 and 10 μs provide large ablations comparable to IRE with tolerable levels of thermal damage and minimized muscle contractions. Lower duration (2 μs) H-FIRE waveforms exhibit the least amount of muscle contractions but require increased voltages which may be accompanied by unwanted thermal damage.},
   keywords = {*Electroporation
Heart Rate
Humans
Male
Muscle Contraction
*Prostatic Neoplasms/surgery
Quality of Life},
   ISSN = {0148-0731},
   DOI = {10.1115/1.4053595},
   year = {2022},
   type = {Journal Article}
}

{"_id":"fiFc4SsZ6cJpdpCJC","bibbaseid":"aycock-vadlamani-jacobs-imran-verbridge-allen-manuchehrabadi-davalos-experimentalandnumericalinvestigationofparametersaffectinghighfrequencyirreversibleelectroporationforprostatecancerablation-2022","author_short":["Aycock, K. N.","Vadlamani, R. A.","Jacobs, E. J.","Imran, K. M.","Verbridge, S. S.","Allen, I. C.","Manuchehrabadi, N.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Aycock"],"firstnames":["K.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Vadlamani"],"firstnames":["R.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Jacobs"],"firstnames":["E.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Imran"],"firstnames":["K.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Verbridge"],"firstnames":["S.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Allen"],"firstnames":["I.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Manuchehrabadi"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Experimental and Numerical Investigation of Parameters Affecting High-Frequency Irreversible Electroporation for Prostate Cancer Ablation","journal":"J Biomech Eng","volume":"144","number":"6","note":"1528-8951 Aycock, Kenneth N Vadlamani, Ram Anand Jacobs, Edward J Imran, Khan Mohammad Verbridge, Scott S Allen, Irving C Manuchehrabadi, Navid Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't United States 2022/01/20 J Biomech Eng. 2022 Jun 1;144(6):061003. doi: 10.1115/1.4053595.","abstract":"While the primary goal of focal therapy for prostate cancer (PCa) is conserving patient quality of life by reducing oncological burden, available modalities use thermal energy or whole-gland radiation which can damage critical neurovascular structures within the prostate and increase risk of genitourinary dysfunction. High-frequency irreversible electroporation (H-FIRE) is a promising alternative ablation modality that utilizes bursts of pulsed electric fields (PEFs) to destroy aberrant cells via targeted membrane damage. Due to its nonthermal mechanism, H-FIRE offers several advantages over state-of-the-art treatments, but waveforms have not been optimized for treatment of PCa. In this study, we characterize lethal electric field thresholds (EFTs) for H-FIRE waveforms with three different pulse widths as well as three interpulse delays in vitro and compare them to conventional irreversible electroporation (IRE). Experiments were performed in non-neoplastic and malignant prostate cells to determine the effect of waveforms on both targeted (malignant) and adjacent (non-neoplastic) tissue. A numerical modeling approach was developed to estimate the clinical effects of each waveform including extent of nonthermal ablation, undesired thermal damage, and nerve excitation. Our findings indicate that H-FIRE waveforms with pulse durations of 5 and 10 μs provide large ablations comparable to IRE with tolerable levels of thermal damage and minimized muscle contractions. Lower duration (2 μs) H-FIRE waveforms exhibit the least amount of muscle contractions but require increased voltages which may be accompanied by unwanted thermal damage.","keywords":"*Electroporation Heart Rate Humans Male Muscle Contraction *Prostatic Neoplasms/surgery Quality of Life","issn":"0148-0731","doi":"10.1115/1.4053595","year":"2022","bibtex":"@article{RN109,\n author = {Aycock, K. N. and Vadlamani, R. A. and Jacobs, E. J. and Imran, K. M. and Verbridge, S. S. and Allen, I. C. and Manuchehrabadi, N. and Davalos, R. V.},\n title = {Experimental and Numerical Investigation of Parameters Affecting High-Frequency Irreversible Electroporation for Prostate Cancer Ablation},\n journal = {J Biomech Eng},\n volume = {144},\n number = {6},\n note = {1528-8951\nAycock, Kenneth N\nVadlamani, Ram Anand\nJacobs, Edward J\nImran, Khan Mohammad\nVerbridge, Scott S\nAllen, Irving C\nManuchehrabadi, Navid\nDavalos, Rafael V\nJournal Article\nResearch Support, Non-U.S. Gov't\nUnited States\n2022/01/20\nJ Biomech Eng. 2022 Jun 1;144(6):061003. doi: 10.1115/1.4053595.},\n abstract = {While the primary goal of focal therapy for prostate cancer (PCa) is conserving patient quality of life by reducing oncological burden, available modalities use thermal energy or whole-gland radiation which can damage critical neurovascular structures within the prostate and increase risk of genitourinary dysfunction. High-frequency irreversible electroporation (H-FIRE) is a promising alternative ablation modality that utilizes bursts of pulsed electric fields (PEFs) to destroy aberrant cells via targeted membrane damage. Due to its nonthermal mechanism, H-FIRE offers several advantages over state-of-the-art treatments, but waveforms have not been optimized for treatment of PCa. In this study, we characterize lethal electric field thresholds (EFTs) for H-FIRE waveforms with three different pulse widths as well as three interpulse delays in vitro and compare them to conventional irreversible electroporation (IRE). Experiments were performed in non-neoplastic and malignant prostate cells to determine the effect of waveforms on both targeted (malignant) and adjacent (non-neoplastic) tissue. A numerical modeling approach was developed to estimate the clinical effects of each waveform including extent of nonthermal ablation, undesired thermal damage, and nerve excitation. Our findings indicate that H-FIRE waveforms with pulse durations of 5 and 10 μs provide large ablations comparable to IRE with tolerable levels of thermal damage and minimized muscle contractions. Lower duration (2 μs) H-FIRE waveforms exhibit the least amount of muscle contractions but require increased voltages which may be accompanied by unwanted thermal damage.},\n keywords = {*Electroporation\nHeart Rate\nHumans\nMale\nMuscle Contraction\n*Prostatic Neoplasms/surgery\nQuality of Life},\n ISSN = {0148-0731},\n DOI = {10.1115/1.4053595},\n year = {2022},\n type = {Journal Article}\n}\n\n","author_short":["Aycock, K. N.","Vadlamani, R. A.","Jacobs, E. J.","Imran, K. M.","Verbridge, S. S.","Allen, I. C.","Manuchehrabadi, N.","Davalos, R. V."],"key":"RN109","id":"RN109","bibbaseid":"aycock-vadlamani-jacobs-imran-verbridge-allen-manuchehrabadi-davalos-experimentalandnumericalinvestigationofparametersaffectinghighfrequencyirreversibleelectroporationforprostatecancerablation-2022","role":"author","urls":{},"keyword":["*Electroporation Heart Rate Humans Male Muscle Contraction *Prostatic Neoplasms/surgery Quality of Life"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["*electroporation heart rate humans male muscle contraction *prostatic neoplasms/surgery quality of life"],"search_terms":["experimental","numerical","investigation","parameters","affecting","high","frequency","irreversible","electroporation","prostate","cancer","ablation","aycock","vadlamani","jacobs","imran","verbridge","allen","manuchehrabadi","davalos"],"title":"Experimental and Numerical Investigation of Parameters Affecting High-Frequency Irreversible Electroporation for Prostate Cancer Ablation","year":2022}