@article{Aziz2022,
abstract = {Schistosomiasis is the second most debilitating neglected tropical disease globally after malaria, with no available therapy to control disease-driven immunopathology. Although schistosomiasis induces a markedly heterogenous immune response, type 2 immunity is the dominating immune response following oviposition. While type 2 immunity has a crucial role in granuloma formation and host survival during the acute stage of disease, its chronic activation can result in tissue scarring, fibrosis, and organ impairment. Here, we discuss recent advances in schistosomiasis, demonstrating how different immune and non-immune cells and signaling pathways are involved in the induction, maintenance, and regulation of type 2 immunity. A better understanding of these immune responses during schistosomiasis is essential to inform the potential development of candidate therapeutic strategies that fine-tune type 2 immunity to ideally modulate schistosomiasis immunopathology.},
author = {Aziz, Nada Abdel and Musaigwa, Fungai and Mosala, Paballo and Berkiks, Inssaf and Brombacher, Frank},
doi = {10.1016/J.IT.2022.06.005},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Aziz et al. - 2022 - Type 2 immunity a two-edged sword in schistosomiasis immunopathology.pdf:pdf},
issn = {1471-4906},
journal = {Trends in Immunology},
keywords = {IL4R$\alpha$,fibro-granulomatous inflammation,fund{\_}not{\_}ack,review,schistosomiasis,type 2 immunity},
mendeley-tags = {fund{\_}not{\_}ack,review},
month = {jul},
pages = {10.1016/j.it.2022.06.005},
pmid = {35835714},
publisher = {Elsevier},
title = {{Type 2 immunity: a two-edged sword in schistosomiasis immunopathology}},
url = {http://www.cell.com/article/S1471490622001211/fulltext http://www.cell.com/article/S1471490622001211/abstract https://www.cell.com/trends/immunology/abstract/S1471-4906(22)00121-1},
year = {2022}
}

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Here, we discuss recent advances in schistosomiasis, demonstrating how different immune and non-immune cells and signaling pathways are involved in the induction, maintenance, and regulation of type 2 immunity. 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