@article{RN264,
   author = {Baan, E. J. and de Roos, E. W. and Engelkes, M. and de Ridder, M. and Pedersen, L. and Berencsi, K. and Prieto-Alhambra, D. and Lapi, F. and Van Dyke, M. K. and Rijnbeek, P. and Brusselle, G. G. and Verhamme, K. M. C.},
   title = {Characterization of Asthma by Age of Onset: A Multi-Database Cohort Study},
   journal = {J Allergy Clin Immunol Pract},
   volume = {10},
   number = {7},
   pages = {1825-1834.e8},
   note = {2213-2201 Baan, Esmé J de Roos, Emmely W Engelkes, Marjolein de Ridder, Maria Pedersen, Lars Berencsi, Klara Prieto-Alhambra, Dani Lapi, Francesco Van Dyke, Melissa K Rijnbeek, Peter Brusselle, Guy G Verhamme, Katia M C Journal Article Meta-Analysis Research Support, Non-U.S. Gov't United States 2022/04/11 J Allergy Clin Immunol Pract. 2022 Jul;10(7):1825-1834.e8. doi: 10.1016/j.jaip.2022.03.019. Epub 2022 Apr 8.},
   abstract = {BACKGROUND: Asthma can occur at any age but the differences in patient characteristics between childhood-, adult-, and late-onset asthma are not well understood. OBJECTIVE: To investigate differences in patients' characteristics by age at asthma onset. METHODS: From 5 European electronic databases, we created a cohort encompassing adult patients with doctor-diagnosed asthma in 2008 to 2013. Patients were categorized based on their age at asthma onset: childhood-onset (age at onset < 18 y), adult-onset (age at onset 18-40 y), and late-onset asthma (age at onset ≥ 40 y). Comorbidities were assessed at study entry. For each characteristic and comorbidity, odds ratios and age- and sex-adjusted odds ratios (OR(adj)) comparing asthma-onset categories were estimated per database and combined in a meta-analysis using a random effect model. RESULTS: In total, 586,436 adult asthma patients were included, 81,691 had childhood-onset, 218,184 adult-onset, and 286,561 late-onset asthma. Overall, 7.3% had severe asthma. Subjects with adult-onset compared with childhood-asthma had higher risks for overweight/obesity (OR(adj) 1.4; 95% CI 1.1-1.8) and lower risks for atopic disorders (OR(adj) 0.8; 95% CI 0.7-0.95). Patients with late-onset compared with adult-onset asthma had higher risks for nasal polyposis (OR(adj) 1.8; 95% CI 1.2-2.6), overweight/obesity (OR(adj) 1.3; 95% CI 1.2-1.4), gastroesophageal reflux disease (OR(adj) 1.4; 95% CI 1.2-1.7), and diabetes (OR(adj) 2.3; 95% CI 1.8-2.9). A significant association between late-onset asthma and uncontrolled asthma was observed (OR(adj) 2.8; 95% CI 1.7-4.5). CONCLUSIONS: This international study demonstrates clear differences in comorbidities between childhood-, adult-, and late-onset asthma phenotypes in adults. Furthermore, patients with late-onset asthma had more frequent uncontrolled asthma.},
   keywords = {Age of Onset
*Asthma/epidemiology
Child
Cohort Studies
Humans
Obesity
*Overweight
Adults
Age at onset
Asthma
Comorbidity
Epidemiology
Exacerbations
General population ,
DOI = 10.1016/j.jaip.2022.03.019},
   year = {2022},
   type = {Journal Article}
}

{"_id":"DCcv3szDYhi43qywQ","bibbaseid":"baan-deroos-engelkes-deridder-pedersen-berencsi-prietoalhambra-lapi-etal-characterizationofasthmabyageofonsetamultidatabasecohortstudy-2022","author_short":["Baan, E. J.","de Roos, E. W.","Engelkes, M.","de Ridder, M.","Pedersen, L.","Berencsi, K.","Prieto-Alhambra, D.","Lapi, F.","Van Dyke, M. K.","Rijnbeek, P.","Brusselle, G. G.","Verhamme, K. M. C."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Baan"],"firstnames":["E.","J."],"suffixes":[]},{"propositions":["de"],"lastnames":["Roos"],"firstnames":["E.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Engelkes"],"firstnames":["M."],"suffixes":[]},{"propositions":["de"],"lastnames":["Ridder"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Pedersen"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Berencsi"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Prieto-Alhambra"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Lapi"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["Van","Dyke"],"firstnames":["M.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Rijnbeek"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Brusselle"],"firstnames":["G.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Verhamme"],"firstnames":["K.","M.","C."],"suffixes":[]}],"title":"Characterization of Asthma by Age of Onset: A Multi-Database Cohort Study","journal":"J Allergy Clin Immunol Pract","volume":"10","number":"7","pages":"1825-1834.e8","note":"2213-2201 Baan, Esmé J de Roos, Emmely W Engelkes, Marjolein de Ridder, Maria Pedersen, Lars Berencsi, Klara Prieto-Alhambra, Dani Lapi, Francesco Van Dyke, Melissa K Rijnbeek, Peter Brusselle, Guy G Verhamme, Katia M C Journal Article Meta-Analysis Research Support, Non-U.S. Gov't United States 2022/04/11 J Allergy Clin Immunol Pract. 2022 Jul;10(7):1825-1834.e8. doi: 10.1016/j.jaip.2022.03.019. Epub 2022 Apr 8.","abstract":"BACKGROUND: Asthma can occur at any age but the differences in patient characteristics between childhood-, adult-, and late-onset asthma are not well understood. OBJECTIVE: To investigate differences in patients' characteristics by age at asthma onset. METHODS: From 5 European electronic databases, we created a cohort encompassing adult patients with doctor-diagnosed asthma in 2008 to 2013. Patients were categorized based on their age at asthma onset: childhood-onset (age at onset < 18 y), adult-onset (age at onset 18-40 y), and late-onset asthma (age at onset ≥ 40 y). Comorbidities were assessed at study entry. For each characteristic and comorbidity, odds ratios and age- and sex-adjusted odds ratios (OR(adj)) comparing asthma-onset categories were estimated per database and combined in a meta-analysis using a random effect model. RESULTS: In total, 586,436 adult asthma patients were included, 81,691 had childhood-onset, 218,184 adult-onset, and 286,561 late-onset asthma. Overall, 7.3% had severe asthma. Subjects with adult-onset compared with childhood-asthma had higher risks for overweight/obesity (OR(adj) 1.4; 95% CI 1.1-1.8) and lower risks for atopic disorders (OR(adj) 0.8; 95% CI 0.7-0.95). Patients with late-onset compared with adult-onset asthma had higher risks for nasal polyposis (OR(adj) 1.8; 95% CI 1.2-2.6), overweight/obesity (OR(adj) 1.3; 95% CI 1.2-1.4), gastroesophageal reflux disease (OR(adj) 1.4; 95% CI 1.2-1.7), and diabetes (OR(adj) 2.3; 95% CI 1.8-2.9). A significant association between late-onset asthma and uncontrolled asthma was observed (OR(adj) 2.8; 95% CI 1.7-4.5). CONCLUSIONS: This international study demonstrates clear differences in comorbidities between childhood-, adult-, and late-onset asthma phenotypes in adults. Furthermore, patients with late-onset asthma had more frequent uncontrolled asthma.","keywords":"Age of Onset *Asthma/epidemiology Child Cohort Studies Humans Obesity *Overweight Adults Age at onset Asthma Comorbidity Epidemiology Exacerbations General population , DOI = 10.1016/j.jaip.2022.03.019","year":"2022","bibtex":"@article{RN264,\r\n author = {Baan, E. J. and de Roos, E. W. and Engelkes, M. and de Ridder, M. and Pedersen, L. and Berencsi, K. and Prieto-Alhambra, D. and Lapi, F. and Van Dyke, M. K. and Rijnbeek, P. and Brusselle, G. G. and Verhamme, K. M. C.},\r\n title = {Characterization of Asthma by Age of Onset: A Multi-Database Cohort Study},\r\n journal = {J Allergy Clin Immunol Pract},\r\n volume = {10},\r\n number = {7},\r\n pages = {1825-1834.e8},\r\n note = {2213-2201 Baan, Esmé J de Roos, Emmely W Engelkes, Marjolein de Ridder, Maria Pedersen, Lars Berencsi, Klara Prieto-Alhambra, Dani Lapi, Francesco Van Dyke, Melissa K Rijnbeek, Peter Brusselle, Guy G Verhamme, Katia M C Journal Article Meta-Analysis Research Support, Non-U.S. Gov't United States 2022/04/11 J Allergy Clin Immunol Pract. 2022 Jul;10(7):1825-1834.e8. doi: 10.1016/j.jaip.2022.03.019. Epub 2022 Apr 8.},\r\n abstract = {BACKGROUND: Asthma can occur at any age but the differences in patient characteristics between childhood-, adult-, and late-onset asthma are not well understood. OBJECTIVE: To investigate differences in patients' characteristics by age at asthma onset. METHODS: From 5 European electronic databases, we created a cohort encompassing adult patients with doctor-diagnosed asthma in 2008 to 2013. Patients were categorized based on their age at asthma onset: childhood-onset (age at onset < 18 y), adult-onset (age at onset 18-40 y), and late-onset asthma (age at onset ≥ 40 y). Comorbidities were assessed at study entry. For each characteristic and comorbidity, odds ratios and age- and sex-adjusted odds ratios (OR(adj)) comparing asthma-onset categories were estimated per database and combined in a meta-analysis using a random effect model. RESULTS: In total, 586,436 adult asthma patients were included, 81,691 had childhood-onset, 218,184 adult-onset, and 286,561 late-onset asthma. Overall, 7.3% had severe asthma. Subjects with adult-onset compared with childhood-asthma had higher risks for overweight/obesity (OR(adj) 1.4; 95% CI 1.1-1.8) and lower risks for atopic disorders (OR(adj) 0.8; 95% CI 0.7-0.95). Patients with late-onset compared with adult-onset asthma had higher risks for nasal polyposis (OR(adj) 1.8; 95% CI 1.2-2.6), overweight/obesity (OR(adj) 1.3; 95% CI 1.2-1.4), gastroesophageal reflux disease (OR(adj) 1.4; 95% CI 1.2-1.7), and diabetes (OR(adj) 2.3; 95% CI 1.8-2.9). A significant association between late-onset asthma and uncontrolled asthma was observed (OR(adj) 2.8; 95% CI 1.7-4.5). CONCLUSIONS: This international study demonstrates clear differences in comorbidities between childhood-, adult-, and late-onset asthma phenotypes in adults. Furthermore, patients with late-onset asthma had more frequent uncontrolled asthma.},\r\n keywords = {Age of Onset\r\n*Asthma/epidemiology\r\nChild\r\nCohort Studies\r\nHumans\r\nObesity\r\n*Overweight\r\nAdults\r\nAge at onset\r\nAsthma\r\nComorbidity\r\nEpidemiology\r\nExacerbations\r\nGeneral population ,\r\nDOI = 10.1016/j.jaip.2022.03.019},\r\n year = {2022},\r\n type = {Journal Article}\r\n}\r\n\r\n","author_short":["Baan, E. 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C."],"key":"RN264","id":"RN264","bibbaseid":"baan-deroos-engelkes-deridder-pedersen-berencsi-prietoalhambra-lapi-etal-characterizationofasthmabyageofonsetamultidatabasecohortstudy-2022","role":"author","urls":{},"keyword":["Age of Onset *Asthma/epidemiology Child Cohort Studies Humans Obesity *Overweight Adults Age at onset Asthma Comorbidity Epidemiology Exacerbations General population","DOI = 10.1016/j.jaip.2022.03.019"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/network/files/qwipow2DJsAxqNp83","dataSources":["PJSqX8FMpCPRdw3CQ","qLDnCcKM9omXNrRY8","TB9sD3avjy7bNxfgS","vDmJPYmHEKAT3tMNL","PcZMFHooKwpboi2he","jZMXEeHTfokmisJDv"],"keywords":["age of onset *asthma/epidemiology child cohort studies humans obesity *overweight adults age at onset asthma comorbidity epidemiology exacerbations general population","doi = 10.1016/j.jaip.2022.03.019"],"search_terms":["characterization","asthma","age","onset","multi","database","cohort","study","baan","de roos","engelkes","de ridder","pedersen","berencsi","prieto-alhambra","lapi","van dyke","rijnbeek","brusselle","verhamme"],"title":"Characterization of Asthma by Age of Onset: A Multi-Database Cohort Study","year":2022}