@article{RN266,
   author = {Baan, E. J. and van den Akker, E. L. T. and Engelkes, M. and de Rijke, Y. B. and de Jongste, J. C. and Sturkenboom, Mcjm and Verhamme, K. M. and Janssens, H. M.},
   title = {Hair cortisol and inhaled corticosteroid use in asthmatic children},
   journal = {Pediatr Pulmonol},
   volume = {55},
   number = {2},
   pages = {316-321},
   note = {1099-0496 Baan, Esmé J Orcid: 0000-0002-0735-4296 van den Akker, Erica L T Engelkes, Marjolein de Rijke, Yolanda B de Jongste, Johan C Sturkenboom, Miriam C J M Verhamme, Katia M Janssens, Hettie M Journal Article Research Support, Non-U.S. Gov't United States 2019/10/28 Pediatr Pulmonol. 2020 Feb;55(2):316-321. doi: 10.1002/ppul.24551. Epub 2019 Oct 25.},
   abstract = {BACKGROUND: Adrenal suppression is a side effect of long-term use of inhaled corticosteroids (ICS). Hair cortisol concentration (HCC) measurement is a noninvasive tool for measuring adrenal function that may be useful for asthmatic patients who are on long-term ICS treatment. The aim of this study was to compare HCC between children with and without asthma and to explore the association between HCC and ICS dose in asthmatic children. METHODS: A cross-sectional observational study in subjects with or without asthma (n = 72 and 226, respectively, age 6-21 years). Hair samples were obtained from the posterior vertex for each subject and data on medication use were collected using questionnaires. HCC was analyzed by liquid chromatography-mass spectrometry in the most proximal 3 cm of hair. RESULTS: Median HCC was significantly lower in subjects with asthma than in subjects without asthma: 1.83 pg/mg and 2.39 pg/mg, respectively (P value after adjustment for age, sex, and body mass index: .036). Median HCC was 1.98 pg/mg in asthmatics using no ICS, 1.84 pg/mg in those using a low dose, 1.75 pg/mg in those on a medium dose, and 1.46 in those using a high ICS dose (P = .54). CONCLUSION: We observed a significantly lower HCC in asthmatics than in healthy controls and a nonsignificant trend of lower HCC with increasing ICS dose. Whether HCC measurement may be used to detect individuals at risk for hypocortisolism and may be useful to monitor adrenal function in asthmatic children using ICS needs to be further investigated.},
   keywords = {Administration, Inhalation
Adrenal Cortex Hormones/administration & dosage/*therapeutic use
Anti-Asthmatic Agents/*therapeutic use
Asthma/*drug therapy
Child
Child, Preschool
Cross-Sectional Studies
Drug-Related Side Effects and Adverse Reactions/drug therapy
Female
Hair/chemistry
Humans
Hydrocortisone/*analysis
Male
adrenal insufficiency
asthma
diagnostic techniques and procedures
drug-related side effects and adverse reactions
glucocorticoids ,
ISSN = 8755-6863 (Print) 1099-0496 ,
DOI = 10.1002/ppul.24551},
   year = {2020},
   type = {Journal Article}
}

{"_id":"nzJvxjuCNoHKqMhFk","bibbaseid":"baan-vandenakker-engelkes-derijke-dejongste-sturkenboom-verhamme-janssens-haircortisolandinhaledcorticosteroiduseinasthmaticchildren-2020","author_short":["Baan, E. J.","van den Akker, E. L. T.","Engelkes, M.","de Rijke, Y. B.","de Jongste, J. C.","Sturkenboom, M.","Verhamme, K. M.","Janssens, H. M."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Baan"],"firstnames":["E.","J."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Akker"],"firstnames":["E.","L.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Engelkes"],"firstnames":["M."],"suffixes":[]},{"propositions":["de"],"lastnames":["Rijke"],"firstnames":["Y.","B."],"suffixes":[]},{"propositions":["de"],"lastnames":["Jongste"],"firstnames":["J.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Sturkenboom"],"firstnames":["Mcjm"],"suffixes":[]},{"propositions":[],"lastnames":["Verhamme"],"firstnames":["K.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Janssens"],"firstnames":["H.","M."],"suffixes":[]}],"title":"Hair cortisol and inhaled corticosteroid use in asthmatic children","journal":"Pediatr Pulmonol","volume":"55","number":"2","pages":"316-321","note":"1099-0496 Baan, Esmé J Orcid: 0000-0002-0735-4296 van den Akker, Erica L T Engelkes, Marjolein de Rijke, Yolanda B de Jongste, Johan C Sturkenboom, Miriam C J M Verhamme, Katia M Janssens, Hettie M Journal Article Research Support, Non-U.S. Gov't United States 2019/10/28 Pediatr Pulmonol. 2020 Feb;55(2):316-321. doi: 10.1002/ppul.24551. Epub 2019 Oct 25.","abstract":"BACKGROUND: Adrenal suppression is a side effect of long-term use of inhaled corticosteroids (ICS). Hair cortisol concentration (HCC) measurement is a noninvasive tool for measuring adrenal function that may be useful for asthmatic patients who are on long-term ICS treatment. The aim of this study was to compare HCC between children with and without asthma and to explore the association between HCC and ICS dose in asthmatic children. METHODS: A cross-sectional observational study in subjects with or without asthma (n = 72 and 226, respectively, age 6-21 years). Hair samples were obtained from the posterior vertex for each subject and data on medication use were collected using questionnaires. HCC was analyzed by liquid chromatography-mass spectrometry in the most proximal 3 cm of hair. RESULTS: Median HCC was significantly lower in subjects with asthma than in subjects without asthma: 1.83 pg/mg and 2.39 pg/mg, respectively (P value after adjustment for age, sex, and body mass index: .036). Median HCC was 1.98 pg/mg in asthmatics using no ICS, 1.84 pg/mg in those using a low dose, 1.75 pg/mg in those on a medium dose, and 1.46 in those using a high ICS dose (P = .54). CONCLUSION: We observed a significantly lower HCC in asthmatics than in healthy controls and a nonsignificant trend of lower HCC with increasing ICS dose. Whether HCC measurement may be used to detect individuals at risk for hypocortisolism and may be useful to monitor adrenal function in asthmatic children using ICS needs to be further investigated.","keywords":"Administration, Inhalation Adrenal Cortex Hormones/administration & dosage/*therapeutic use Anti-Asthmatic Agents/*therapeutic use Asthma/*drug therapy Child Child, Preschool Cross-Sectional Studies Drug-Related Side Effects and Adverse Reactions/drug therapy Female Hair/chemistry Humans Hydrocortisone/*analysis Male adrenal insufficiency asthma diagnostic techniques and procedures drug-related side effects and adverse reactions glucocorticoids , ISSN = 8755-6863 (Print) 1099-0496 , DOI = 10.1002/ppul.24551","year":"2020","bibtex":"@article{RN266,\r\n author = {Baan, E. J. and van den Akker, E. L. T. and Engelkes, M. and de Rijke, Y. B. and de Jongste, J. C. and Sturkenboom, Mcjm and Verhamme, K. M. and Janssens, H. M.},\r\n title = {Hair cortisol and inhaled corticosteroid use in asthmatic children},\r\n journal = {Pediatr Pulmonol},\r\n volume = {55},\r\n number = {2},\r\n pages = {316-321},\r\n note = {1099-0496 Baan, Esmé J Orcid: 0000-0002-0735-4296 van den Akker, Erica L T Engelkes, Marjolein de Rijke, Yolanda B de Jongste, Johan C Sturkenboom, Miriam C J M Verhamme, Katia M Janssens, Hettie M Journal Article Research Support, Non-U.S. Gov't United States 2019/10/28 Pediatr Pulmonol. 2020 Feb;55(2):316-321. doi: 10.1002/ppul.24551. Epub 2019 Oct 25.},\r\n abstract = {BACKGROUND: Adrenal suppression is a side effect of long-term use of inhaled corticosteroids (ICS). Hair cortisol concentration (HCC) measurement is a noninvasive tool for measuring adrenal function that may be useful for asthmatic patients who are on long-term ICS treatment. The aim of this study was to compare HCC between children with and without asthma and to explore the association between HCC and ICS dose in asthmatic children. METHODS: A cross-sectional observational study in subjects with or without asthma (n = 72 and 226, respectively, age 6-21 years). Hair samples were obtained from the posterior vertex for each subject and data on medication use were collected using questionnaires. HCC was analyzed by liquid chromatography-mass spectrometry in the most proximal 3 cm of hair. RESULTS: Median HCC was significantly lower in subjects with asthma than in subjects without asthma: 1.83 pg/mg and 2.39 pg/mg, respectively (P value after adjustment for age, sex, and body mass index: .036). Median HCC was 1.98 pg/mg in asthmatics using no ICS, 1.84 pg/mg in those using a low dose, 1.75 pg/mg in those on a medium dose, and 1.46 in those using a high ICS dose (P = .54). CONCLUSION: We observed a significantly lower HCC in asthmatics than in healthy controls and a nonsignificant trend of lower HCC with increasing ICS dose. Whether HCC measurement may be used to detect individuals at risk for hypocortisolism and may be useful to monitor adrenal function in asthmatic children using ICS needs to be further investigated.},\r\n keywords = {Administration, Inhalation\r\nAdrenal Cortex Hormones/administration & dosage/*therapeutic use\r\nAnti-Asthmatic Agents/*therapeutic use\r\nAsthma/*drug therapy\r\nChild\r\nChild, Preschool\r\nCross-Sectional Studies\r\nDrug-Related Side Effects and Adverse Reactions/drug therapy\r\nFemale\r\nHair/chemistry\r\nHumans\r\nHydrocortisone/*analysis\r\nMale\r\nadrenal insufficiency\r\nasthma\r\ndiagnostic techniques and procedures\r\ndrug-related side effects and adverse reactions\r\nglucocorticoids ,\r\nISSN = 8755-6863 (Print) 1099-0496 ,\r\nDOI = 10.1002/ppul.24551},\r\n year = {2020},\r\n type = {Journal Article}\r\n}\r\n\r\n","author_short":["Baan, E. J.","van den Akker, E. L. T.","Engelkes, M.","de Rijke, Y. B.","de Jongste, J. C.","Sturkenboom, M.","Verhamme, K. M.","Janssens, H. M."],"key":"RN266","id":"RN266","bibbaseid":"baan-vandenakker-engelkes-derijke-dejongste-sturkenboom-verhamme-janssens-haircortisolandinhaledcorticosteroiduseinasthmaticchildren-2020","role":"author","urls":{},"keyword":["Administration","Inhalation Adrenal Cortex Hormones/administration & dosage/*therapeutic use Anti-Asthmatic Agents/*therapeutic use Asthma/*drug therapy Child Child","Preschool Cross-Sectional Studies Drug-Related Side Effects and Adverse Reactions/drug therapy Female Hair/chemistry Humans Hydrocortisone/*analysis Male adrenal insufficiency asthma diagnostic techniques and procedures drug-related side effects and adverse reactions glucocorticoids","ISSN = 8755-6863 (Print) 1099-0496","DOI = 10.1002/ppul.24551"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/network/files/qwipow2DJsAxqNp83","dataSources":["xnfSapys2DoEfaJa2","oJZGB5PnqjLfyucHk","PJSqX8FMpCPRdw3CQ","qLDnCcKM9omXNrRY8","TB9sD3avjy7bNxfgS","vDmJPYmHEKAT3tMNL","PcZMFHooKwpboi2he","jZMXEeHTfokmisJDv"],"keywords":["administration","inhalation adrenal cortex hormones/administration & dosage/*therapeutic use anti-asthmatic agents/*therapeutic use asthma/*drug therapy child child","preschool cross-sectional studies drug-related side effects and adverse reactions/drug therapy female hair/chemistry humans hydrocortisone/*analysis male adrenal insufficiency asthma diagnostic techniques and procedures drug-related side effects and adverse reactions glucocorticoids","issn = 8755-6863 (print) 1099-0496","doi = 10.1002/ppul.24551"],"search_terms":["hair","cortisol","inhaled","corticosteroid","use","asthmatic","children","baan","van den akker","engelkes","de rijke","de jongste","sturkenboom","verhamme","janssens"],"title":"Hair cortisol and inhaled corticosteroid use in asthmatic children","year":2020}