Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient. Baang, J. H., Smith, C., Mirabelli, C., Valesano, A. L, Manthei, D. M, Bachman, M. A, Wobus, C. E, Adams, M., Washer, L., Martin, E. T, & Lauring, A. S The Journal of Infectious Diseases, 223(1):23–27, January, 2021. ![Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Abstract We describe a case of chronic coronavirus disease 2019 (COVID-19) in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for at least 119 days. The patient had 3 admissions related to COVID-19 over a 4-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The patient’s lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.
@article{baang_prolonged_2021,
title = {Prolonged {Severe} {Acute} {Respiratory} {Syndrome} {Coronavirus} 2 {Replication} in an {Immunocompromised} {Patient}},
volume = {223},
issn = {0022-1899, 1537-6613},
url = {https://academic.oup.com/jid/article/223/1/23/5934826},
doi = {10.1093/infdis/jiaa666},
abstract = {Abstract
We describe a case of chronic coronavirus disease 2019 (COVID-19) in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for at least 119 days. The patient had 3 admissions related to COVID-19 over a 4-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The patient’s lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.},
language = {en},
number = {1},
urldate = {2021-05-08},
journal = {The Journal of Infectious Diseases},
author = {Baang, Ji Hoon and Smith, Christopher and Mirabelli, Carmen and Valesano, Andrew L and Manthei, David M and Bachman, Michael A and Wobus, Christiane E and Adams, Michael and Washer, Laraine and Martin, Emily T and Lauring, Adam S},
month = jan,
year = {2021},
pages = {23--27},
}
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